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Инфекция и иммунитет, 2020 COVID-19 is a zoonotic disease that showed higher levels of transmissibility in humans. Coronavirus has the largest recognized genome (28–33 kb) of a positive-sense single stranded RNA.
F. A. Isihak, M. A. Hamad, N. G. Mustafa
doaj +1 more source
Review of using saliva for COVID-19 testing
Scientific Dental Journal, 2022 Saliva is a hypotonic solution of gingival, salivary acini, and exudate sulcus fluid from the oral mucosa. Saliva contains proteins, DNA, RNA, micro-RNA, and metabolites; hence, it can be detected early in viruses, bacteria, as well as systemic diseases.
Jessica Endriyana +1 more
doaj +1 more source
Focused ACE2 CRISPR screen of HuH7 ACE2-enriched cells.
, 2022 MAGeCK output for gene-level and individual gRNA-level enrichment or depletion in ACE2-high cells relative to ACE2-negative cells. Negative log2-fold change and RRA scores indicate gRNA depletion in ACE2-high cells (gene disruption associated with ...
Andrew W. Tai (10149208) +11 more
core +1 more source
Transcription of Ace2 regulated genes in differential ace2 expressing mutants
, 2021 Cell division in Schizosaccharomyces pombe is influenced by ace2 and its associated genes, including the target genes, eng1 and agn1. Since it has a cell cycle typical to most eukaryotes, Sch.
Aysha, Afnan Hossain
core
Genome-wide ACE2 CRISPR screen of HuH7 ACE2-enriched cells.
, 2022 MAGeCK output for gene-level and individual gRNA-level enrichment or depletion in ACE2-high cells relative to ACE2-negative cells. Negative log2-fold change and RRA scores indicate gRNA depletion in ACE2-high cells (gene disruption associated with ...
Andrew W. Tai (10149208) +11 more
core +1 more source
Biology, Medicine & Natural Product ChemistryAngiotensin Converting Enzymes (ACEs) are carboxypeptidase enzymes involved in the renin-angiotensin system (RAS), which catalyze angiotensin I by cleavage of the peptide bond. ACE1 has been known as a target for antihypertensive drugs.
Navista Sri Octa Ujiantari +1 more
doaj +1 more source
Study of Concentration of Angiotensin-Converting Enzyme 2 Receptor Proteins in Different Age-groups and Genders with Reference to Susceptibility toward Severe Acute Respiratory Syndrome Coronavirus 2 [PDF]
Indian Journal of Respiratory CareAim and background: Angiotensin-Converting Enzyme 2 (ACE2) was the main host cell receptor through which Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) ensured its entry into human cells.
Shareef M Buvvaji +14 more
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Ursodeoxycholic Acid Reduces Angiotensin-Converting Enzyme 2 Activity and Suppresses Cytokine Storm Syndrome in Patients With Coronavirus Disease 2019. [PDF]
MedComm (2020)SARS‐CoV‐2 infection causes COVID‐19 and stimulates immune cells, such as dendritic cells, monocytes, and macrophages, to increase levels of many cytokines. Ursodeoxycholic acid (UDCA) inhibits farnesoid X receptor (FXR), resulting in a decrease in the activity of angiotensin‐converting enzyme 2 (ACE2), the main receptor on the membrane for SARS‐CoV‐2.
Tong Z +8 more
europepmc +2 more sources
Pharmacologic modulation of ACE2 expression [PDF]
Current Hypertension Reports, 2008 Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic
Soler, María José +3 more
openaire +2 more sources
Covalent Bonding Aptamer with Enhanced SARS-CoV-2 RBD-ACE2 Blocking and Pseudovirus Neutralization Activities [PDF]
, 2021 SARS-CoV-2 uses its spike protein receptor-binding domain (RBD) to interact with the angiotensin-converting enzyme 2 (ACE2) receptor on host cells. Inhibitors of the RBD-ACE2 interaction are therefore promising drug candidates in treating COVID-19. Here,
Yu, Xiang, Zichen, Qin, Yiying, Zhu
core +2 more sources