Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Bai, B +5 more
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Growing concerns on male reproductive health amidst COVID-19 pandemic
Journal of Family Medicine and Primary Care, 2022 Blood–testis barrier is body's innate mechanism to defend germ cells by creating a physical and immunological barrier. But some viral infections are known to evade it.
Megha Agrawal, Vikas Kumar, Gyan Vardhan
doaj +1 more source
COVID-19 clinical implications: the significance of nanomedicine [PDF]
BioImpacts, 2020 COVID-19 pandemic has profoundly affected the lives of humans worldwide. We no longer experience the same quality of life and need to come up with effective solutions to combat the clinical implications.
Jaleh Barar
doaj +1 more source
Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]
, 2016 AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke +50 more
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ACE2 pathway regulates thermogenesis and energy metabolism [PDF]
eLife, 2021 Identification of key regulators of energy homeostasis holds important therapeutic promise for metabolic disorders, such as obesity and diabetes. ACE2 cleaves angiotensin II (Ang II) to generate Ang-(1-7) which acts mainly through the Mas1 receptor.
Chuan-Hai Zhang +10 more
openaire +3 more sources
Journal of Inflammation Research, 2021 Wuping Bao,1,* Xue Zhang,1,* Yubiao Jin,2,* Huijuan Hao,1 Fu Yang,3 Dongning Yin,1 Xi Chen,3 Yishu Xue,1 Lei Han,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of ...
Bao W +9 more
doaj
Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]
, 2011 Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet +10 more
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Clinical utility of cardiac troponin measurement in COVID-19 infection [PDF]
, 2020 The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission.
Gaze, D.C., Gaze, D.C.
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Generation of Nano-Antibodies Targeting the SNMP1 Membrane Receptor of <i>Spodoptera littoralis</i> Using Extracellular Vesicles. [PDF]
J Extracell BiolExtracellular vesicles (EVs) represent an excellent platform for the expression of recombinant membrane proteins and their use in llama immunization to generate nano‐antibodies (Nabs). In this study, we present a novel strategy, termed the multi‐layer approach, for EV immobilization in biopanning and ELISA applications.
Dogliani A +6 more
europepmc +2 more sources
Journal of Cardiovascular Pharmacology, 2015 The health of the cardiovascular and pulmonary systems is inextricably linked to the renin-angiotensin system (RAS). Physiologically speaking, a balance between the vasodeleterious (Angiotensin-converting enzyme [ACE]/Angiotensin II [Ang II]/Ang II type 1 receptor [AT1R]) and vasoprotective (Angiotensin-converting enzyme 2 [ACE2]/Angiotensin-(1-7) [Ang-
Colleen T, Cole-Jeffrey +4 more
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