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Metabolic Syndrome “Interacts” With COVID-19
BIO Integration, 2021 COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emerged as a global pandemic and poses a great threat to public health and society in general.
Zeling Guo +3 more
doaj +1 more source
ACE2-Ig and RBD-Ig inhibits in vitro SARS-CoV-2 infection.
, 2021 (A) ACE2 enzymatic activity assay. Recombinant human ACE2 and ACE2-Ig were incubated with and without an ACE2 inhibitor, then MCA based peptide substrate was added and plate was immediately inserted in the fluorescent plate reader ...
Orit Berhani (11136072) +15 more
core +1 more source
ACE2-independent SARS-CoV-2 entry in macrophages.
, 2022 (A-B) Representative ACE2 mRNA expression (A) and flow cytometry profiles showing ACE2 surface expression (B) of HEK293T cells stably expressing ACE2 and primary MDMs from multiple donors.
Sallieu Jalloh (14002696) +11 more
core +1 more source
ACE2 alterations in kidney disease [PDF]
Nephrology Dialysis Transplantation, 2013 Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney
María José, Soler +2 more
openaire +2 more sources
Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients
Open Medicine, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is now a serious public health problem. Angiotensin-converting enzyme 2 (ACE2) recognized as the receptor of SARS-CoV is also necessary for SARS-CoV-2.
Ren Peng, Gong Caifeng, Ma Shaohua
doaj +1 more source
Fiyz̤, 2021 Background: Recently in 2019, a novel virus from coronavirus family (Sars-CoV-2) was introduced in China. ACE2 is a zinc metalloprotease played role in the angiotensin system.
Mosleh HR +4 more
doaj
Resveratrol supplementation reduces ACE2 expression in human adipose tissue
Adipocyte, 2021 Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 ...
Marlies de Ligt +5 more
doaj +1 more source
Clinical and Experimental Hypertension, 2019 Objective: To investigate the effects of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary arterial cell apoptosis during pulmonary vascular remodeling associated with pulmonary arterial hypertension (PAH) and to elucidate potential ...
Daole Yan +3 more
doaj +1 more source
SARS-CoV-2 and endothelial cell interaction in COVID-19: molecular perspectives
Vascular Biology, 2021 SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has been declared a pandemic by the World Health Organization. The clinical evolution of COVID-19 ranges from asymptomatic infection to death.
Roberta Giordo +3 more
doaj +1 more source
Inhibition of ACE2‐Spike Interaction by an ACE2 Binder Suppresses SARS‐CoV‐2 Entry [PDF]
Angewandte Chemie International Edition, 2022 AbstractThe emergence of SARS‐CoV‐2 variants is a significant concern in developing effective therapeutics and vaccines in the middle of the ongoing COVID‐19 pandemic. Here, we have identified a novel small molecule that inhibited the interactions between SARS‐CoV‐2 spike RBDs and ACE2 by modulating ACE2 without impairing its enzymatic activity ...
Young‐Hee Shin +7 more
openaire +2 more sources