Results 41 to 50 of about 93,409 (274)

Pharmacologic modulation of ACE2 expression [PDF]

Current Hypertension Reports, 2008
Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic
Soler, María José, Barrios, Clara, Oliva, Raymond, Batlle, Daniel   +3 more
openaire   +2 more sources

Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC

Journal of Inflammation Research, 2021
Wuping Bao,1,* Xue Zhang,1,* Yubiao Jin,2,* Huijuan Hao,1 Fu Yang,3 Dongning Yin,1 Xi Chen,3 Yishu Xue,1 Lei Han,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of ...
Bao W, Zhang X, Jin Y, Hao H, Yang F, Yin D, Chen X, Xue Y, Han L, Zhang M   +9 more
doaj  

ACE2 level as a marker of CVD [PDF]

Nature Reviews Cardiology, 2020
Higher levels of angiotensin-converting enzyme 2 in plasma are associated with a greater risk of major cardiovascular disease events, according to a global, population-based study.
openaire   +2 more sources

Fragment Molecular Orbital Based Interaction Analyses on Complexes Between RBD Variants and ACE2

, 2021
The spike protein plays an important role in the infection of SARS-CoV-2 to human cells, and the binding affinity of receptor binding domain (RBD) to angiotensin-converting enzyme 2 (ACE2) is of special interest.
Shun, Kitahara, Koji, Okuwaki, Yuji, Mochizuki, Ryo, Hatada, Yusuke, Tachino, Kazuki, Akisawa   +5 more
core   +1 more source

Correlations of gene polymorphisms of angiotensin-converting enzyme 2 with onset and prognosis of hypertrophic cardiomyopathy [PDF]

Journal of Medical Biochemistry
Background: To investigate the correlations of the gene polymorphisms of angiotensin-converting enzyme 2 (ACE2) with the onset and prognosis of hypertrophic cardiomyopathy (HCM), so as to provide references for the early prevention and precise treatment ...
Li Sujuan, Lin Xizhi, Ye Haoting, Li Biyun, Zeng Siyu, Mei Qinghua, Huang Yukai, Liu Yixuan   +7 more
doaj   +1 more source

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

, 2023
nvestigation of potential hosts of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks of spillover and spillback.
Trono, D., Myasnikov, Alexander, Trono, Didier, Lau, Kelvin, Beckert, B., Uchikawa, E., Pojer, Florence, Uchikawa, Emiko, Nazarov, Sergey, Ni, D., Stahlberg, Henning, Stahlberg, H., Turelli, P., Lau, K., Turelli, Priscilla, Nazarov, S., Myasnikov, A., Pojer, F., Ni, Dongchun, Beckert, Bertrand   +19 more
core   +1 more source

COVID-19: an updated review

Инфекция и иммунитет, 2020
COVID-19 is a zoonotic disease that showed higher levels of transmissibility in humans. Coronavirus has the largest recognized genome (28–33 kb) of a positive-sense single stranded RNA.
F. A. Isihak, M. A. Hamad, N. G. Mustafa
doaj   +1 more source

Review of using saliva for COVID-19 testing

Scientific Dental Journal, 2022
Saliva is a hypotonic solution of gingival, salivary acini, and exudate sulcus fluid from the oral mucosa. Saliva contains proteins, DNA, RNA, micro-RNA, and metabolites; hence, it can be detected early in viruses, bacteria, as well as systemic diseases.
Jessica Endriyana, Endang Winiati Bachtiar   +1 more
doaj   +1 more source

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X, Jiang, Y, Karteris, E, Bai, B, Chen, J, Karteris, Emmanouil, Bai, Bo, Jiang, Yunlu, Cai, Xin, Chen, Jing   +9 more
core   +1 more source

Transcription of Ace2 regulated genes in differential ace2 expressing mutants

, 2021
Cell division in Schizosaccharomyces pombe is influenced by ace2 and its associated genes, including the target genes, eng1 and agn1. Since it has a cell cycle typical to most eukaryotes, Sch.
Aysha, Afnan Hossain
core