Soluble ACE2 Is Filtered into the Urine
Kidney360, 2022 Key Points Combining unique genetic and surgical models, we demonstrate that both renal and systemic sources contribute to angiotensin-converting enzyme 2 (ACE2) detected in the urine in angiotensin II–mediated hypertension.Micropuncture coupled with nanoproteomics confirm detection of ACE2 in ...
Jonathan W. Nelson +11 more
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ACE2, Metformin, and COVID-19 [PDF]
iScience, 2020 COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19.
Malhotra, Atul +3 more
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Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]
, 2009 Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey +12 more
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Genetic Landscape of the ACE2 Coronavirus Receptor [PDF]
Circulation, 2022 Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory ...
Yang Z +70 more
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ACE2-Fc and ACE2(NN)-Fc fusion proteins are heavily glycosylated with complex-type N-glycans.
, 2022 Reduced SDS-page of ACE2-Fc (a) and ACE2(NN)-Fc (b) before and after treatment with PNGase F. (c) MALDI-TOF-MS spectra of permethylated N-glycans identified in ACE2-Fc (top) and ACE2(NN)-Fc(bottom).
Hang Xie (218360) +9 more
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ACE2-Fc and ACE2(NN)-Fc binding affinity to S protein variants using biolayer interferometry.
, 2022 Representative electropherograms of ACE2-Fc (a) and ACE2(NN)-Fc (b) binding to S protein variants: parental, alpha, beta, delta, and omicron. The binding affinity (c), disassociation rate (d), and association rate (e) of ACE2-Fc to S protein variants ...
Hang Xie (218360) +9 more
core +1 more source
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range [PDF]
, 2023 nvestigation of potential hosts of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks of spillover and spillback.
Trono, D. +19 more
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Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection [PDF]
Journal of Tropical Life Science, 2021 There isaccumulating evidence suggesting that ACE2, the host cell receptor for the spike (S) protein of the SARS-CoV-2, mediates viral entry and infection, is under epigenetic control.
Custer C. Deocaris, Malona V. Alinsug
doaj +1 more source
, 2022 ACE2 dependence values calculated following flow cytometry values are shown on the left, while values calculated through microscopy are shown on the right.
Anna M. Bruchez (11146776) +4 more
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The Effect of ACE2 Inhibitor MLN-4760 on the Interaction of SARS-CoV-2 Spike Protein with Human ACE2: A Molecular Dynamics Study [PDF]
, 2020 A previous study shows that an ACE2 enzymatic activity inhibitor efficiently blocks the interaction of SARS-CoV spike protein with human ACE2 and may be effective in preventing the coronavirus membrane fusion and entry to human cells. The report suggests
Avrin, Ghanaeian +3 more
core +1 more source