Results 21 to 30 of about 93,409 (274)

ACE2, Metformin, and COVID-19 [PDF]

iScience, 2020
COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19.
Malhotra, Atul, Hepokoski, Mark, McCowen, Karen C, Shyy, John Y-J   +3 more
openaire   +5 more sources

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey, McBride, Martin, Graham, Delyth, Nicklin, Stuart A., Masson, Rachel, Craig, Margaret Anne, Gregorevic, Paul, Napoli, Claudio, Dominiczak, Anna F., Allen, James M., Baker, Andrew H., Gilday, Kirsten, Chamberlain, Jeffrey S.   +12 more
core   +1 more source

ACE2 alterations in kidney disease [PDF]

Nephrology Dialysis Transplantation, 2013
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney
María José, Soler, Jan, Wysocki, Daniel, Batlle   +2 more
openaire   +2 more sources

ACE2-Fc and ACE2(NN)-Fc fusion proteins are heavily glycosylated with complex-type N-glycans.

, 2022
Reduced SDS-page of ACE2-Fc (a) and ACE2(NN)-Fc (b) before and after treatment with PNGase F. (c) MALDI-TOF-MS spectra of permethylated N-glycans identified in ACE2-Fc (top) and ACE2(NN)-Fc(bottom).
Hang Xie (218360), Alicia M. Matthews (14227586), V. Ashutosh Rao (7635122), Talia Faison (14227595), Thomas G. Biel (3605438), Uriel Ortega-Rodriguez (13527813), Xin Bush (14227592), Tongzhong Ju (52651), Cyrus Agarabi (8896346), Vincent M. Falkowski (14227589)   +9 more
core   +1 more source

ACE2-Fc and ACE2(NN)-Fc binding affinity to S protein variants using biolayer interferometry.

, 2022
Representative electropherograms of ACE2-Fc (a) and ACE2(NN)-Fc (b) binding to S protein variants: parental, alpha, beta, delta, and omicron. The binding affinity (c), disassociation rate (d), and association rate (e) of ACE2-Fc to S protein variants ...
Hang Xie (218360), Alicia M. Matthews (14227586), V. Ashutosh Rao (7635122), Talia Faison (14227595), Thomas G. Biel (3605438), Uriel Ortega-Rodriguez (13527813), Xin Bush (14227592), Tongzhong Ju (52651), Cyrus Agarabi (8896346), Vincent M. Falkowski (14227589)   +9 more
core   +1 more source

Inhibition of ACE2‐Spike Interaction by an ACE2 Binder Suppresses SARS‐CoV‐2 Entry [PDF]

Angewandte Chemie International Edition, 2022
AbstractThe emergence of SARS‐CoV‐2 variants is a significant concern in developing effective therapeutics and vaccines in the middle of the ongoing COVID‐19 pandemic. Here, we have identified a novel small molecule that inhibited the interactions between SARS‐CoV‐2 spike RBDs and ACE2 by modulating ACE2 without impairing its enzymatic activity ...
Young‐Hee Shin, Kiyoung Jeong, Jihye Lee, Hyo Jung Lee, Junhyeong Yim, Jonghoon Kim, Seungtaek Kim, Seung Bum Park   +7 more
openaire   +2 more sources

ACE2-dependent infection of various chimeric RBD spike pseudoviruses and cells overexpressing various ACE2 orthologs.

, 2022
ACE2 dependence values calculated following flow cytometry values are shown on the left, while values calculated through microscopy are shown on the right.
Anna M. Bruchez (11146776), Nidhi Shukla (4813350), Anh T. Pham (2700751), Kenneth A. Matreyek (11146779), Sarah M. Roelle (11146770)   +4 more
core   +1 more source

ACE2-Ig and RBD-Ig inhibits in vitro SARS-CoV-2 infection.

, 2021
(A) ACE2 enzymatic activity assay. Recombinant human ACE2 and ACE2-Ig were incubated with and without an ACE2 inhibitor, then MCA based peptide substrate was added and plate was immediately inserted in the fluorescent plate reader ...
Orit Berhani (11136072), Or Alfi (11859174), Stipan Jonjic (139671), Gil Roi (11859168), Sharon Melamed (650685), Eran Zahavy (247118), Inbal Kol (11859165), Tomer Israely (650684), Abigael Eva Chaouat (11568088), Dana Wolf (5632841), Boaz Politi (650686), Ofer Mandelboim (23173), Hagit Achdout (175954), Einat B. Vitner (11859171), Tihana Lenac Rovis (8907359), Ilija Brizic (437748)   +15 more
core   +1 more source

ACE2 and Diabetes: ACE of ACEs? [PDF]

Diabetes, 2010
The mechanisms involved in the development of diabetes and its complications are complex, with a long list of potential derangements on different pathways (1,2). In this commentary, we discuss angiotensin converting enzyme 2 (ACE2) as a potential participant in the development of both islet β-cell insufficiency early on and in the development of ...
Batlle, Daniel, Jose Soler, Maria, Ye, Minghao   +2 more
openaire   +2 more sources

Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients

Open Medicine, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is now a serious public health problem. Angiotensin-converting enzyme 2 (ACE2) recognized as the receptor of SARS-CoV is also necessary for SARS-CoV-2.
Ren Peng, Gong Caifeng, Ma Shaohua
doaj   +1 more source