Results 21 to 30 of about 81,776 (169)
Resveratrol supplementation reduces ACE2 expression in human adipose tissue
Adipocyte, 2021 Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 ...
Marlies de Ligt +5 more
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Clinical and Experimental Hypertension, 2019 Objective: To investigate the effects of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary arterial cell apoptosis during pulmonary vascular remodeling associated with pulmonary arterial hypertension (PAH) and to elucidate potential ...
Daole Yan +3 more
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SARS-CoV-2 and endothelial cell interaction in COVID-19: molecular perspectives
Vascular Biology, 2021 SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has been declared a pandemic by the World Health Organization. The clinical evolution of COVID-19 ranges from asymptomatic infection to death.
Roberta Giordo +3 more
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ACE2 and Diabetes: ACE of ACEs? [PDF]
Diabetes, 2010 The mechanisms involved in the development of diabetes and its complications are complex, with a long list of potential derangements on different pathways (1,2). In this commentary, we discuss angiotensin converting enzyme 2 (ACE2) as a potential participant in the development of both islet β-cell insufficiency early on and in the development of ...
Batlle, Daniel +2 more
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Inhibition of ACE2‐Spike Interaction by an ACE2 Binder Suppresses SARS‐CoV‐2 Entry [PDF]
Angewandte Chemie International Edition, 2022 AbstractThe emergence of SARS‐CoV‐2 variants is a significant concern in developing effective therapeutics and vaccines in the middle of the ongoing COVID‐19 pandemic. Here, we have identified a novel small molecule that inhibited the interactions between SARS‐CoV‐2 spike RBDs and ACE2 by modulating ACE2 without impairing its enzymatic activity ...
Young‐Hee Shin +7 more
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Journal of Interdisciplinary Medicine, 2020 The aim of this review is to provide a short update on whether treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) has beneficial or harmful effects in patients infected with SARS-CoV-2. Epidemiological
Blîndu Emanuel +4 more
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Growing concerns on male reproductive health amidst COVID-19 pandemic
Journal of Family Medicine and Primary Care, 2022 Blood–testis barrier is body's innate mechanism to defend germ cells by creating a physical and immunological barrier. But some viral infections are known to evade it.
Megha Agrawal, Vikas Kumar, Gyan Vardhan
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COVID-19 clinical implications: the significance of nanomedicine [PDF]
BioImpacts, 2020 COVID-19 pandemic has profoundly affected the lives of humans worldwide. We no longer experience the same quality of life and need to come up with effective solutions to combat the clinical implications.
Jaleh Barar
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Journal of Inflammation Research, 2021 Wuping Bao,1,* Xue Zhang,1,* Yubiao Jin,2,* Huijuan Hao,1 Fu Yang,3 Dongning Yin,1 Xi Chen,3 Yishu Xue,1 Lei Han,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of ...
Bao W +9 more
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Journal of the American Society of Nephrology, 2006 Abundant, well-accepted evidence demonstrates a complete tissue renin-angiotensin system (RAS) within the kidney that plays many roles in the control of the intrarenal vasculature, as well in the control of glomerular and tubular processes ([1][1]).
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