Results 11 to 20 of about 81,776 (169)

ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa

International Journal of Molecular Sciences, 2022
Angiotensin-converting enzyme 2 (ACE2) is a protein widely expressed in numerous cell types, with different biological roles mainly related to the renin-angiotensin system. Recently, ACE2 has been in the spotlight due to its involvement in the SARS-CoV-2 entry into cells.
Ramal-Sanchez Marina, Castellini C., Cimini C., Taraschi A., Valbonetti L., Barbonetti A., Bernabò Nicola, Barboni B.   +7 more
openaire   +3 more sources

Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?

Clinical and Experimental Hypertension, 2022
Background: ACE2, a component of the non-classic renin-angiotensin system (RAS), acts as a functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) spike protein, which enables the entry of the virus into the host cells.
Shakhi Shylesh C.M, Arya V S, Kanthlal S. K., Uma Devi P.   +3 more
doaj   +1 more source

Genetic Landscape of the ACE2 Coronavirus Receptor [PDF]

Circulation, 2022
Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory ...
Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N, Ning Z, Zheng C, Wang Y, Huang T, He Y, Guo H, Ying K, Gustafsson S, Prins B, Ramisch A, Dermitzakis ET, Png G, Eriksson N, Haessler J, Hu X, Zanetti D, Boutin T, Hwang SJ, Wheeler E, Pietzner M, Raffield LM, Kalnapenkis A, Peters JE, Viñuela A, Gilly A, Elmståhl S, Dedoussis G, Petrie JR, Polašek O, Folkersen L, Chen Y, Yao C, Võsa U, Pairo-Castineira E, Clohisey S, Bretherick AD, Rawlik K, GenOMICC Consortium†, IMI-DIRECT Consortium†, Esko T, Enroth S, Johansson Å, Gyllensten U, Langenberg C, Levy D, Hayward C, Assimes TL, Kooperberg C, Manichaikul AW, Siegbahn A, Wallentin L, Lind L, Zeggini E, Schwenk JM, Butterworth AS, Michaëlsson K, Pawitan Y, Joshi PK, Baillie JK, Mälarstig A, Reiner AP, Wilson JF, Shen X   +70 more
openaire   +12 more sources

Soluble ACE2 Is Filtered into the Urine

Kidney360, 2022
Key Points Combining unique genetic and surgical models, we demonstrate that both renal and systemic sources contribute to angiotensin-converting enzyme 2 (ACE2) detected in the urine in angiotensin II–mediated hypertension.Micropuncture coupled with nanoproteomics confirm detection of ACE2 in ...
Jonathan W. Nelson, David I. Ortiz-Melo, Natalie K. Mattocks, Jacqueline M. Emathinger, Jessica Prescott, Katherine Xu, Robert C. Griffiths, Rumie Wakasaki, Paul D. Piehowski, Michael P. Hutchens, Thomas M. Coffman, Susan B. Gurley   +11 more
openaire   +2 more sources

Maternal Diet During Pregnancy and COVID-19 Susceptibility of Offspring: The “Thrifty Phenotype Hypothesis” Connection [PDF]

Journal of Tropical Life Science, 2021
There isaccumulating evidence suggesting that ACE2, the host cell receptor for the spike (S) protein of the SARS-CoV-2, mediates viral entry and infection, is under epigenetic control.
Custer C. Deocaris, Malona V. Alinsug
doaj   +1 more source

Metabolic Syndrome “Interacts” With COVID-19

BIO Integration, 2021
COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emerged as a global pandemic and poses a great threat to public health and society in general.
Zeling Guo, Shanping Jiang, Zilun Li, Sifan Chen   +3 more
doaj   +1 more source

ACE2 alterations in kidney disease [PDF]

Nephrology Dialysis Transplantation, 2013
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney
María José, Soler, Jan, Wysocki, Daniel, Batlle   +2 more
openaire   +2 more sources

ACE2, Metformin, and COVID-19 [PDF]

iScience, 2020
COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19.
Malhotra, Atul, Hepokoski, Mark, McCowen, Karen C, Shyy, John Y-J   +3 more
openaire   +5 more sources

Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients

Open Medicine, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is now a serious public health problem. Angiotensin-converting enzyme 2 (ACE2) recognized as the receptor of SARS-CoV is also necessary for SARS-CoV-2.
Ren Peng, Gong Caifeng, Ma Shaohua
doaj   +1 more source

Evaluation of the effect of angiotensin converting enzyme2 in corona pandemic affect female infertility: A review article

Fiyz̤, 2021
Background: Recently in 2019, a novel virus from coronavirus family (Sars-CoV-2) was introduced in China. ACE2 is a zinc metalloprotease played role in the angiotensin system.
Mosleh HR, Mehdizadeh M, Moradi F, Moeinzadeh A, Shabani R   +4 more
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