Results 11 to 20 of about 132,338 (329)

Association Between ACE2 and Lung Diseases

Infection and Drug Resistance
Cheng Su,1,* Cai Li,2,* Xinyi Hu,3,* Jing Wang,1,* Linlin Liu,4,* Xianfeng Zhang,4 Yeqing Tong4 1School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Infectious Disease ...
Su C, Li C, Hu X, Wang J, Liu L, Zhang X, Tong Y   +6 more
doaj   +3 more sources

Effects of Exercise on ACE2 [PDF]

Obesity, 2020
In addition to obesity, conditions that are typically associated with lower physical activity (higher age, hypertension, diabetes, coronary heart disease, and chronic obstructive pulmonary disease) are associated with worse clinical outcomes from COVID-19 (2) [ ]neither vaccines nor effective and safe pharmacotherapies against the novel severe acute
Klöting, Nora, Ristow, Michael, Blüher, Matthias   +2 more
openaire   +4 more sources

Genetic Landscape of the ACE2 Coronavirus Receptor [PDF]

Circulation, 2022
Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory ...
Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N, Ning Z, Zheng C, Wang Y, Huang T, He Y, Guo H, Ying K, Gustafsson S, Prins B, Ramisch A, Dermitzakis ET, Png G, Eriksson N, Haessler J, Hu X, Zanetti D, Boutin T, Hwang SJ, Wheeler E, Pietzner M, Raffield LM, Kalnapenkis A, Peters JE, Viñuela A, Gilly A, Elmståhl S, Dedoussis G, Petrie JR, Polašek O, Folkersen L, Chen Y, Yao C, Võsa U, Pairo-Castineira E, Clohisey S, Bretherick AD, Rawlik K, GenOMICC Consortium†, IMI-DIRECT Consortium†, Esko T, Enroth S, Johansson Å, Gyllensten U, Langenberg C, Levy D, Hayward C, Assimes TL, Kooperberg C, Manichaikul AW, Siegbahn A, Wallentin L, Lind L, Zeggini E, Schwenk JM, Butterworth AS, Michaëlsson K, Pawitan Y, Joshi PK, Baillie JK, Mälarstig A, Reiner AP, Wilson JF, Shen X   +70 more
openaire   +14 more sources

ACE2, Metformin, and COVID-19 [PDF]

iScience, 2020
COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19.
Malhotra, Atul, Hepokoski, Mark, McCowen, Karen C, Shyy, John Y-J   +3 more
openaire   +5 more sources

ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa

International Journal of Molecular Sciences, 2022
Angiotensin-converting enzyme 2 (ACE2) is a protein widely expressed in numerous cell types, with different biological roles mainly related to the renin-angiotensin system. Recently, ACE2 has been in the spotlight due to its involvement in the SARS-CoV-2 entry into cells.
Ramal-Sanchez Marina, Castellini C., Cimini C., Taraschi A., Valbonetti L., Barbonetti A., Bernabò Nicola, Barboni B.   +7 more
openaire   +3 more sources

ACE2

, 2023
Official Full Name angiotensin I converting enzyme 2 Background The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin
openaire   +2 more sources

ACE2 as therapeutic agent

Clinical Science, 2020
Abstract The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance.
Li, Qiuhong, Grant, Maria B., Richards, Elaine M., Raizada, Mohan K.   +3 more
openaire   +2 more sources

ACE2 alterations in kidney disease [PDF]

Nephrology Dialysis Transplantation, 2013
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney
María José, Soler, Jan, Wysocki, Daniel, Batlle   +2 more
openaire   +2 more sources

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Allen, James M., Baker, Andrew H., Chamberlain, Jeffrey S., Craig, Margaret Anne, Dominiczak, Anna F., Gilday, Kirsten, Graham, Delyth, Gregorevic, Paul, Masson, Rachel, McBride, Martin, Napoli, Claudio, Nicklin, Stuart A., Smith, Godfrey   +12 more
core   +1 more source

Pharmacologic modulation of ACE2 expression [PDF]

Current Hypertension Reports, 2008
Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic
Soler, María José, Barrios, Clara, Oliva, Raymond, Batlle, Daniel   +3 more
openaire   +2 more sources