Results 11 to 20 of about 97,072 (276)

ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa [PDF]

International Journal of Molecular Sciences, 2022
Angiotensin-converting enzyme 2 (ACE2) is a protein widely expressed in numerous cell types, with different biological roles mainly related to the renin-angiotensin system. Recently, ACE2 has been in the spotlight due to its involvement in the SARS-CoV-2
Taraschi A., Bernabò Nicola, Ramal-Sanchez Marina, Castellini C., Cimini C., Valbonetti L., Barbonetti A., Barboni B.   +7 more
core   +6 more sources

Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels [PDF]

Pediatric Research, 2022
BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19. Viral entry requires ACE2 and transmembrane protease serine 2 (TMPRSS2).
Gironacci, Mariela M., Corradi, Gerardo R., Silva, Mauro G., Corradi, Gerardo Raul, de Matteo, Elena Noemí, de Matteo, Elena, Di Camillo, Norma Alicia, Falcoff, Nora L., Silva, Mauro Gastón, Seguel, Rolando F., Tabaj, Gabriela C., Gironacci, Mariela Mercedes, Di Camillo, Norma, Guman, Gabriela R., Nuñez, Myriam   +14 more
core   +4 more sources

ACE2-Decorated Virus-Like Particles Effectively Block SARS-CoV-2 Infection [PDF]

International Journal of Nanomedicine
Canan Bayraktar,1,* Alisan Kayabolen,1,* Arda Odabas,1 Aysegul Durgun,1 Ipek Kok,1 Kenan Sevinc,1 Aroon Supramaniam,2 Adi Idris,2,3 Tugba Bagci-Onder1 1Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul ...
Bayraktar C, Kayabolen A, Odabas A, Durgun A, Kok I, Sevinc K, Supramaniam A, Idris A, Bagci-Onder T   +8 more
doaj   +3 more sources

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking. [PDF]

Adv Sci (Weinh)
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Chen Z, He Z, Guo H, Shi M, Liang R, Liu L, Dai Y, Zhao Q, Liu K, Zhou Y, Zhang Y, Ren J, Ju B, Fang Q, Li Z, Zhao P, Zheng M, Cai L.   +17 more
europepmc   +2 more sources

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS-CoV-2 Variants. [PDF]

Adv Sci (Weinh)
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Stainer S, Zhu R, Reithofer M, Stadlmayr G, Stadlbauer K, Prangkio P, Rippel C, Hahn M, Kasztner AE, Stohl S, Bednar P, Ruzek D, Glück D, Tampé R, Wozniak-Knopp G, Oh YJ, Klausberger M, Hinterdorfer P.   +17 more
europepmc   +2 more sources

COVID-19 and cardiovascular system—a comprehensive review [PDF]

Reviews in Cardiovascular Medicine, 2021
Coronavirus disease 2019 (COVID-19), a mystified cryptic virus has challenged the mankind that has brought life to a standstill. Catastrophic loss of life, perplexed healthcare system and the downfall of global economy are some of the outcomes of this
Ibrahim AlShahrani, Jagadish Hosmani, Vidya Gurram Shankar, Abdulaziz AlShahrani, Rafi Ahmad Togoo, Syed M Yassin, Shahrukh Khan, Shankargouda Patil   +7 more
doaj   +1 more source

Effects of Exercise on ACE2 [PDF]

Obesity, 2020
In addition to obesity, conditions that are typically associated with lower physical activity (higher age, hypertension, diabetes, coronary heart disease, and chronic obstructive pulmonary disease) are associated with worse clinical outcomes from COVID-19 (2) [ ]neither vaccines nor effective and safe pharmacotherapies against the novel severe acute
Klöting, Nora, Ristow, Michael, Blüher, Matthias   +2 more
openaire   +5 more sources

A Dual-Membrane Biomimetic Nanoplatform Enables Triple-Modal Therapy Against SARS-CoV-2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi. [PDF]

Adv Sci (Weinh)
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Li H, Zhang B, Shang C, Li Y, Zhao T, Liu S, Liu D, Che J, Zhang C, Wu P, Yang W, Ding J, Ran Y, Zhai Y, Xiao H, Gao J, Li X, Gao C, Li L, Li Z.   +19 more
europepmc   +2 more sources

Secondary Publication: The Pathophysiology of COVID-19 (Coronavirus Disease 2019) Caused by the Infection of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)

Tokyo Women's Medical University Journal, 2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a wide range of clinical manifestations, including acute respiratory distress syndrome, severe inflammation, abnormal blood coagulation, and ...
Ayako Nakamura-Ishizu, Fumio Nakamura
doaj   +1 more source

COVID-19: Time for a clinical classification?

Indian Journal of Pathology and Microbiology, 2022
COVID-19 pandemic caused by SARS-CoV-2 virus has been around for 2 years causing significant health-care catastrophes in most parts of the world. The understanding of COVID-19 continues to expand, with multiple newer developments such as the presence of ...
Dinesh Jothimani, Radhika Venugopal, Shruthi Manoharan, Silas Danielraj, Swetha Palanichamy, Gomathy Narasimhan, Ilankumaran Kaliamoorthy, Mohamed Rela   +7 more
doaj   +1 more source