Results 91 to 100 of about 97,072 (276)
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery
Clinical Science, 2020 Abstract Angiotensin-converting enzyme II (ACE2) is a homologue of angiotensin-converting enzyme discovered in 2000. From the initial discovery, it was recognized that the kidneys were organs very rich on ACE2. Subsequent studies demonstrated the precise localization of ACE2 within the kidney and the importance of this enzyme in the ...
Lores, Enrique +2 more
openaire +2 more sources
P-030 ACE2 receptor and its isoform short-ACE2 are expressed on human spermatozoa
Human Reproduction, 2022 Abstract Study question Do human spermatozoa express angiotensin-converting enzyme 2 (ACE2) receptor? What would be its localization? Summary answer Human spermatozoa express uniformly ACE2 on the sperm head and the flagellum ...
Ramal Sanchez, M +7 more
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Structural comparison of Y453F RBD/mink ACE2 and WT RBD/human ACE2 complexes.
, 2021 (A)The overall structure is shown as ribbons. The Y453F-RBD is shown in cyan and mink ACE2 in green. The WT-RBD and human ACE2 are shown in magenta and orange, respectively. (B) Interaction residues around position 34 of human and mink ACE2.
Rong Zhang (44942) +14 more
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Arrayed validation of ACE2 modifiers.
, 2022 (A-B) Percentage of surface ACE2-positive cells after CRISPR-mediated single gene disruption of the indicated target gene or a nontargeting control on either a HuH7 parental wild-type (A) or serially ACE2-enriched background (B).
Andrew W. Tai (10149208) +11 more
core +1 more source
ACE and ACE2 in kidney disease
World Journal of Nephrology, 2015 Renin angiotensin system (RAS) activation has a significant influence on renal disease progression. The classical angiotensin-converting enzyme (ACE)-angiotensin II (Ang II)-Ang II type 1 (AT1) axis is considered to control the effects of RAS activation on renal disease.
Sonoo, Mizuiri, Yasushi, Ohashi
openaire +2 more sources
Advanced Science, EarlyView.Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng +14 more
wiley +1 more source
In silico study of intrinsic dynamics of full-length apo-ACE2 and RBD-ACE2 complex
Computational and Structural Biotechnology Journal, 2021 The key step for SARS-CoV-2 to infect human cells is the membrane fusion triggered by the binding of the viral extracellular Spike protein to the human extracellular receptor, the angiotensin-converting enzyme 2 (ACE2). Although the Cryo-electron microscopy (Cryo-EM) uncovered the static atomic details of ACE2 homodimers, there is still a lack of ...
Qing Liu +3 more
openaire +3 more sources
The SARS-CoV2 - ACE2 link: A physiopathological analysis
, 2020 The Covid-19 pandemic represents an unsolved problem which has caused numerous fatalities. At the present time, there is no vaccination available or curative therapy.
Hamlet, S +10 more
core +1 more source
Advanced Science, EarlyView.Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang +11 more
wiley +1 more source
Advanced Science, EarlyView.Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie +24 more
wiley +1 more source