Results 111 to 120 of about 97,072 (276)

A Schizosaccharomyces pombe ace2 teljes génjének és egy csonkított változatának klónozása

, 2015
A dolgozatban a hasadó élesztők csoportjába tartozó Sch. pombe faj ace2 transzkripciós faktorának vizsgálatával foglalkoztam. Célom volt, hogy megvizsgáljam, hogyan változik a sejtek fenotípusa, ha az ace2 N-terminális végéről hiányzik egy génszakasz, és
Balogh, Bianka
core  

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

ACE2 ACTIVATION PROMOTES ANTITHROMBOTIC ACTIVITY

The FASEB Journal, 2009
Hyperactivity of the axis ACE/AngII/AT1R of the renin‐angiotensin system is associated with occurrence of acute thrombotic event. Recently a novel concept of a counterrugulatory axis, ACE2/Ang‐(1‐7)/Mas, has emerged. We hypothesized that ACE2 would be protective against thrombosis.
Rodrigo A, Fraga-Silva, Brian S, Sorg, Mamta, Wankhede, Casey, Dedeugd, Joo Y, Jun, Matthew B, Baker, Yan, Li, Ronald K, Castellano, Michael J, Katovich, Mohan K, Raizada, Anderson J, Ferreira   +10 more
openaire   +2 more sources

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

A Schizosaccharomyces pombe Ace2 protein szekvenciájának vizsgálata

, 2018
A S. pombe hasadással osztódik, mely során a sejtek a növekedèst ès a mitózist követően, sejtciklusuk utolsó szakaszában középvonaluknál válnak szét utódsejtekké. Az Ace2 transzkripciós faktor fontos szerepet tölt be ennek a folyamatnak a lejàtszódásában.
Valkócz, Réka
core  

Analysis of ACE2 modifiers.

, 2022
(A) Top 10 molecular function ontologies enriched in genes identified as ACE2 modifiers relative to all genes tested in the focused CRISPR library.
Andrew W. Tai (10149208), Vi T. Tang (8356986), Emily J. Sherman (10053054), Cristen J. Willer (7800014), Jonathan Z. Sexton (2263105), Christiane E. Wobus (7610555), Kyle Leix (12174683), Taslima G. Khan (12174680), Sarah E. Graham (10053057), Carmen Mirabelli (152454), Brian T. Emmer (8356980), Andrew A. Kennedy (2450572)   +11 more
core   +1 more source

Association of IFN‐γ +874 T/A Polymorphism With COVID‐19 Susceptibility, Severity, and Inflammatory Response: A Case–Control Study From Southern Iran

Journal of Clinical Laboratory Analysis, EarlyView.
Graphical abstract illustrating the association between IFN‐γ +874 T/A polymorphism and COVID‐19 outcomes. TA and AA genotypes are linked to increased susceptibility, higher inflammatory markers (notably IL‐6), greater disease severity, and longer hospitalization.
Nasir Arefinia, Bahman Aghcheli, Seyed Mohammad Ali Hashemi, Zohreh‐al‐sadat Ghoreshi, Emad Behboudi   +4 more
wiley   +1 more source

Csonkolt ace2 mutáns allélok klónozása

, 2019
Az RNS polimerázokat szabályozni kell, amit eukarióta sejtekben specifikus fehérjék végeznek, amelyeket transzkripciós faktoroknak nevezünk. Ezek a specifikus fehérjék, így más fehérje kódoló gének működését is szabályozzák.
Páll, Krisztián
core  

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source