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ACE2 and Diabetic Complications

Current Pharmaceutical Design, 2007
Angiotensin converting enzyme (ACE) is a key enzyme in the renin angiotensin system (RAS) and converts angiotensin (Ang) I to the vasoconstrictor Ang II, which is thought to be responsible for most of the physiological and pathophysiological effects of the RAS.
Rachael G, Dean, Louise M, Burrell
openaire   +2 more sources

Role of ACE2 in COVID-19

Folia Pharmacologica Japonica, 2022
In the renin-angiotensin system (RAS), angiotensin II (AngII) converted by angiotensin converting enzyme (ACE) exerts a strong physiological activity via the AT1 receptor (AT1R). Thus, the ACE-AngII-AT1R axis positively regulates RAS. On the other hand, angiotensin converting enzyme 2 (ACE2) is known to negatively regulate RAS by degrading AngII into ...
openaire   +2 more sources

ACE2 PET to reveal the dynamic patterns of ACE2 recovery in an infection model with pseudocorona virus

Journal of Medical Virology, 2023
AbstractDue to the COVID‐19 pandemic, a series of sequelae, such as fatigue, tachypnea, and ageusia, appeared in long COVID patients, but the pathological basis was still uncertain. The targeted radiopharmaceuticals were of potential to systemically and dynamically trace the pathological changes.
Xiao, Li   +12 more
openaire   +2 more sources

The Role of ACE2 in Cardiovascular Physiology

Trends in Cardiovascular Medicine, 2003
The renin-angiotensin system (RAS) is critically involved in cardiovascular and renal function and in disease conditions, and has been shown to be a far more complex system than initially thought. A recently discovered homologue of angiotensin-converting enzyme (ACE)--ACE2--appears to negatively regulate the RAS.
Gavin Y, Oudit   +3 more
openaire   +2 more sources

The ACE2 model

2019
This paper proposes a new taxonomy of video-game players: the ACE2 model. Building upon related work in player taxonomies, the ACE2 model sets out to refine the established Bartle’s taxonomy of player types by incorporating the aspect of creation play (e.g., as exhibited in modern games such as Minecraft), thereby rendering the refined model more ...
van Dam, Thomas, Bakkes, Sander
openaire   +1 more source

Overexpression of human ACE2 protein in mouse fibroblasts stably transfected with the intact ACE2 gene

Virology
Infection by SARS-CoV-2 is dependent on binding of the viral spike protein to angiotensin converting enzyme 2 (ACE2), a membrane glycoprotein expressed on epithelial cells in the human upper respiratory tract. Recombinant ACE2 protein has potential application for anti-viral therapy.
Feiyue Teng, Oleg Gang, Paul Freimuth
openaire   +2 more sources

Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID‐19 Therapy

Advanced Materials, 2021
Fangwei Wang, Long Zhang, Aijun Wang
exaly  

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