Results 121 to 130 of about 97,072 (276)

COVID-19 and ACE2 receptor in different tissues: From pathophysiologic function to therapeutic responses [PDF]

open access: yesArchives of Razi Institute
SARS-CoV-2, the virus responsible for COVID-19, is characterized by its high transmission rate, leading to a global pandemic. Millions of people have lost their lives due to the infection caused by this virus.
Mohammad Karimian   +2 more
doaj   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu   +2 more
wiley   +1 more source

Immunohistochemistry for ACE2.

open access: yes, 2013
(A) ACE2 stained RV, (B) control RV, (C) ACE2 stained kidney, (D) control kidney. 400× magnification.
Jennifer A. Johnson (349929)   +3 more
core   +1 more source

Impact of COVID‐19 and Vaccination on Lower Urinary Tract Symptoms: Insights From a Prospective Cohort Study

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Aims To evaluate the prevalence, clinical course, and risk factors of lower urinary tract symptoms (LUTS) in patients hospitalized with COVID‐19, and to assess associations with comorbidities, disease severity, and vaccination status. Methods We conducted a prospective cohort study of adult patients hospitalized with confirmed COVID‐19, who ...
Julia Duarte de Souza   +12 more
wiley   +1 more source

A 11-residue domain of Ace2 as the binding target for Amn1 to mediate Ace2 proteolysis.

open access: yes, 2018
(a) RNA (by RT-qPCR assay) and protein (by western blotting assay) levels of SWI5 in YL1C and YL1C Δamn1 strains. (b) the diagram of Ace2*(where the 11-residue domain of Ace2 was replaced by the corresponding aligned region in Swi5).
Xiaohua Hu (39389)   +6 more
core   +1 more source

Target‐site mutations and phenotypic failure in Myzus persicae against pyrethroids and carbamates in central Europe

open access: yesPest Management Science, EarlyView.
Molecular screening of 140 field‐collected Myzus persicae aphids revealed target‐site mutations L1014F, M918L, M918T, and L932F in the sodium channel and S431F in Ace2. The M918L mutation was the primary driver of high pyrethroid (cypermethrin) resistance, while S431F served as a definitive marker for carbamate (pirimicarb) resistance.
Jitka Stara   +3 more
wiley   +1 more source

The degree of BST2 expression in A549-ACE2-BST2 cells is comparable to that afforded by IFNα stimulation.

open access: yes
The levels of BST2 in A549-ACE2 cells engineered to constitutively express BST2 were compared to HeLa cells, which express BST2 endogenously, and parental A549-ACE2 cells treated with IFNα.
Sydney Simpson (5132285)   +5 more
core   +1 more source

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

open access: yes
ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai   +4 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng   +6 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

open access: yesPhytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko   +3 more
wiley   +1 more source

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