Results 121 to 130 of about 132,338 (329)

ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery

Clinical Science, 2020
Abstract Angiotensin-converting enzyme II (ACE2) is a homologue of angiotensin-converting enzyme discovered in 2000. From the initial discovery, it was recognized that the kidneys were organs very rich on ACE2. Subsequent studies demonstrated the precise localization of ACE2 within the kidney and the importance of this enzyme in the ...
Lores, Enrique, Wysocki, Jan, Batlle, Daniel   +2 more
openaire   +2 more sources

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

COVID-19 Infection: Implications for Perioperative and Critical Care Physicians. [PDF]

, 2020
Healthcare systems worldwide are responding to Coronavirus Disease 2019 (COVID-19), an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Patients with COVID-19 can progress from asymptomatic or
Greenland, John R, London, Martin J, Michelow, Marilyn D, Wang, Linlin   +3 more
core  

Impact of COVID‐19 and Vaccination on Lower Urinary Tract Symptoms: Insights From a Prospective Cohort Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims To evaluate the prevalence, clinical course, and risk factors of lower urinary tract symptoms (LUTS) in patients hospitalized with COVID‐19, and to assess associations with comorbidities, disease severity, and vaccination status. Methods We conducted a prospective cohort study of adult patients hospitalized with confirmed COVID‐19, who ...
Julia Duarte de Souza, Jose de Bessa Jr., Natássia Cristina Carboni Truzzi, Carolina Trigo Rocha, Bruno Camargo Rocha Paim de Araujo, Julyana Kanate Mazzoni Moromizato, Thulio Bosi Vieira Brandão, Rachel Mazoni Costa, Marcelo Hisano, Zein Mohamed Sammour, Homero Bruschini, William Carlos Nahas, Cristiano Mendes Gomes   +12 more
wiley   +1 more source

ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2

Genetics and Molecular Biology
The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to host-cell infection. We performed a comparative genomic analysis of 70 ACE2 placental mammal orthologues to
Bibiana S.O. Fam, Pedro Vargas-Pinilla, Carlos Eduardo G. Amorim, Vinicius A. Sortica, Maria Cátira Bortolini   +4 more
doaj   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Key residues of the receptor binding domain in the spike protein of SARS-CoV-2 mediating the interactions with ACE2: a molecular dynamics study [PDF]

, 2021
Yanmei Yang, Yunju Zhang, Yuanyuan Qu, Chao Zhang, Xue‐Wei Liu, Mingwen Zhao, Yuguang Mu, Weifeng Li   +7 more
openalex   +1 more source

Podocyte ACE2 protects against diabetic nephropathy [PDF]

Kidney International, 2012
As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzyme 2 (ACE2), which can decrease ...
openaire   +2 more sources

COVID-19 as a viral functional ACE2 deficiency disorder with ACE2 related multi-organ disease

Medical Hypotheses, 2020
SARS-CoV-2, the agent of COVID-19, shares a lineage with SARS-CoV-1, and a common fatal pulmonary profile but with striking differences in presentation, clinical course, and response to treatment. In contrast to SARS-CoV-1 (SARS), COVID-19 has presented as an often bi-phasic, multi-organ pathology, with a proclivity for severe disease in the elderly ...
Gan, Rosemary, Rosoman, Nicholas P., Henshaw, David J.E., Noble, Euan P., Georgius, Peter, Sommerfeld, Nigel   +5 more
openaire   +3 more sources

Analysis of the nursing diagnosis of [ineffective breathing pattern (00032)] in patients hospitalized with COVID‐19: A cross‐sectional study

International Journal of Nursing Knowledge, EarlyView.
Abstract Purpose To analyze the prevalence, accuracy of clinical indicators and related factors of the nursing diagnosis of ineffective breathing pattern (00032) in patients hospitalized due to COVID‐19. Methods This is a cross‐sectional study conducted in a public hospital, involving 250 adult hospitalizations between 2020 and 2021.
Caio Rodrigo Menezes dos Santos, Thiago de Jesus Santos, Andreia Centenaro Vaez, Damião da Conceição Araújo   +3 more
wiley   +1 more source