Results 121 to 130 of about 77,670 (298)

The low-entropy hydration shell at the binding site of spike RBD determines the contagiousness of SARS-CoV-2 variants [PDF]

arXiv, 2022
The infectivity of SARS-CoV-2 depends on the binding affinity of the receptor-binding domain (RBD) of the spike protein with the angiotensin converting enzyme 2 (ACE2) receptor. The calculated RBD-ACE2 binding energies indicate that the difference in transmission efficiency of SARS-CoV-2 variants cannot be fully explained by electrostatic interactions,
arxiv  

Enzymatic Production of Opine‐type Chiral Amines with Controlled Stereoselectivity

ChemCatChem, Accepted Article.
Chiral secondary amine dicarboxylic acid derivatives are key building blocks of several peptidomimetic angiotensin‐converting enzyme (ACE2) inhibitors. Reductive amination of α‐keto acids with α‐amino esters can yield orthogonally functionalized derivatives facilitating further chemical modifications. Biocatalysis offers a sustainable and selective way
András Telek, Gergő Dargó, Regina Kovács, Zsófia Molnár, Beáta G. Vértessy, Gábor Tasnádi   +5 more
wiley   +1 more source

Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2 [PDF]

arXiv, 2020
The steep climbing of victims caused by the new coronavirus disease 2019 (COVID-19) throughout the planet is sparking an unprecedented effort to identify effective therapeutic regimens to tackle the pandemic. The SARS-CoV-2 virus is known to gain entry into various cell types through the binding of one of its surface proteins (spike) to the host ...
arxiv  

Association of Comorbidities with Coronavirus Disease 2019: A Review

Annals of the National Academy of Medical Sciences (India), 2020
The novel Coronavirus disease 2019 (COVID-19) pandemic started with few cases of pneumonia of unknown origin in Wuhan, China. It has now become one of the significant public health emergencies of all time.
Prasenjit Mitra, Smriti Suri, Taru Goyal, Radhieka Misra, Kuldeep Singh, M. K. Garg, Sanjeev Misra, Praveen Sharma   +7 more
doaj   +1 more source

A hydrophobic-interaction-based mechanism trigger docking between the SARS CoV 2 spike and angiotensin-converting enzyme 2 [PDF]

arXiv, 2020
A recent experimental study found that the binding affinity between the cellular receptor human angiotensin converting enzyme 2 (ACE2) and receptor-binding domain (RBD) in spike (S) protein of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is more than 10-fold higher than that of the original severe acute respiratory syndrome ...
arxiv  

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

ESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher, Roger Hodkinson, William Makis, Peter A. McCullough   +3 more
wiley   +1 more source

Association of ACE2 Rs2074192 and Rs233574 and AGT Rs699 Gene Polymorphisms with Obesity and Disease Severity In A Cohort Of COVID-19 Affected Syrians

Syrian Journal for Science and Innovation
Since the year 2020, accumulating data have identified numerous factors playing cardinal role in inter-individual variations for COVID-19 morbidity including age, obesity, hypertension, comorbidities, in addition to genetic susceptibility.
Majd Aljamali
doaj   +1 more source

Prediction of repurposed drugs for treating lung injury in COVID-19 [PDF]

arXiv, 2020
Coronavirus disease (COVID-19) is an infectious disease discovered in 2019 and currently in outbreak across the world. Lung injury with severe respiratory failure is the leading cause of death in COVID-19, brought by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv  

ACE2 and COVID-19 Susceptibility and Severity

Aging and disease, 2022
Sick, male, and older populations are more vulnerable to COVID-19. However, it remains unclear whether a common mechanism exists across different demographic characteristics. SARS-CoV-2 infection is initiated by the specific binding of the viral spike protein to angiotensin-converting enzyme 2 (ACE2).
openaire   +2 more sources

COVID-19: is the ACE2 just a foe?

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2020
I read with great interest and pleasure the recent editorial article "Covid-19 infection 31 and mortality – A physiologist's perspective enlightening clinical features and plausible interventional 32 strategies" by Abassi ZA and colleagues (1). In the article, the authors suggested blockage of 33 angiotensin-converting enzyme 2 (ACE2) as a potential ...
openaire   +5 more sources