Results 131 to 140 of about 149,286 (348)

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

COVID’s Razor: RAS Imbalance, the Common Denominator Across Disparate, Unexpected Aspects of COVID-19

Diabetes, Metabolic Syndrome and Obesity, 2020
Maureen Czick,1 Christine Shapter,2 Robert Shapter3 1University of Connecticut, Department of Anesthesia, Farmington, CT, USA; 2 University of Saint Joseph, West Hartford, CT, USA; 3Independent Consultant ( Medical Research, Medical Communications, and ...
Czick M, Shapter C, Shapter R
doaj  

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

Nature Communications, 2020
Study of the interactions established between the viral glycoproteins and their host receptors is of critical importance for a better understanding of virus entry into cells. The novel coronavirus SARS-CoV-2 entry into host cells is mediated by its spike
Jinsung Yang, Simon Petitjean, M. Koehler, Qingrong Zhang, Andra C Dumitru, Wenzhang Chen, Sylvie Derclaye, S. Vincent, P. Soumillion, D. Alsteens   +9 more
semanticscholar   +1 more source

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains

bioRxiv, 2022
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition.
Tyler N. Starr, Allison J. Greaney, Cameron Stewart, A. Walls, William W. Hannon, D. Veesler, Jesse D. Bloom   +6 more
semanticscholar   +1 more source

GDF15 and ACE2 stratify COVID19 patients according to severity while ACE2 mutations increase infection susceptibility

Frontiers in Cellular and Infection Microbiology, 2022
ABSTRACTCoronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments.
Margalida Torrens-Mas, Catalina M. Perelló-Reus, Neus Trias-Ferrer, Lesly Ibargüen-González, Catalina Crespí, Aina Maria Galmes-Panades, Aina Maria Galmes-Panades, Cayetano Navas-Enamorado, Andres Sanchez-Polo, Javier Piérola-Lopetegui, Luis Masmiquel, Lorenzo Socias Crespi, Carles Barcelo, Marta Gonzalez-Freire   +13 more
openaire   +5 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells

Cells, 2020
In December 2019, a novel coronavirus (SARS-CoV-2) was identified in COVID-19 patients in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and the use of the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2 ...
Zhengpin Wang, Xiaojiang Xu
semanticscholar   +1 more source

Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte [PDF]

, 2021
Nunzia D’Onofrio, Lucia Scisciola, Celestino Sardu, Maria Consiglia Trotta, Marisa De Feo, Ciro Maiello, Pasquale Mascolo, Francesco De Micco, Fabrizio Turriziani, Emilia Municinò, Pasquale Monetti, Antonio Lombardi, Maria Napolitano, Federica Zito Marino, Andrea Ronchi, Vincenzo Grimaldi, Anca Hermenean, Maria Rosaria Rizzo, Michelangela Barbieri, Renato Franco, Carlo Pietro Campobasso, Claudio Napoli, Maurizio Municinò, Giuseppe Paolisso, Maria Luisa Balestrieri, Raffaele Marfella   +25 more
openalex   +1 more source

Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2 [PDF]

, 2020
SUMMARYThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme 2 (ACE2). ACE2 is also the viral receptor of SARS-CoV (SARS-CoV-1), a related coronavirus that emerged in 2002-2003.
Mou, Huihui, Quinlan, Brian D., Peng, Haiyong, Guo, Yan, Peng, Shoujiao, Zhang, Lizhou, Davis-Gardner, Meredith E., Gardner, Matthew R., Crynen, Gogce, Voo, Zhi Xiang, Bailey, Charles C., Alpert, Michael D., Rader, Christoph, Choe, Hyeryun, Farzan, Michael   +14 more
openaire   +2 more sources

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source