Results 131 to 140 of about 77,670 (298)

Synthetic Biology‐Based Engineering Cells for Drug Delivery

Exploration, EarlyView.
Synthetic biology‐based therapeutic cells for drug delivery: Engineered cells effectively transport and release drugs through their intelligence and controllability, such as feedback pathways and external stimuli (e.g., light and ultrasound). The integration of nanotechnology, including nanoparticles, biofilms, and artificial cells, enhances ...
Wenzhe Yi, Shuangshuang Hu, Xindi Qian, Wenlu Yan, Yaping Li   +4 more
wiley   +1 more source

Modeling the molecular impact of SARS-CoV-2 infection on the renin-angiotensin system [PDF]

arXiv, 2020
SARS-CoV-2 coronavirus infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors ...
arxiv  

COVID-19, ACE2, and the cardiovascular consequences

American Journal of Physiology-Heart and Circulatory Physiology, 2020
The novel SARS coronavirus SARS-CoV-2 pandemic may be particularly deleterious to patients with underlying cardiovascular disease (CVD). The mechanism for SARS-CoV-2 infection is the requisite binding of the virus to the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) and internalization of the complex by the host cell.
Andrew M. South, Debra I. Diz, Mark C. Chappell   +2 more
openaire   +3 more sources

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, EarlyView.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source

Featuring ACE2 binding SARS-CoV and SARS-CoV-2 through a conserved evolutionary pattern of amino acid residues [PDF]

arXiv, 2020
Spike (S) glycoproteins mediate the coronavirus entry into the host cell. The S1 subunit of S-proteins contains the receptor-binding domain (RBD) that is able to recognize different host receptors, highlighting its remarkable capacity to adapt to their hosts along the viral evolution.
arxiv  

COVID-19 clinical presentations: the modern mimic of other conditions

South Sudan Medical Journal, 2021
The coronavirus pandemic (COVID-19) has placed enormous challenges on the health sector. Diagnosis is one of these challenges, where a clinical presentation may suggest a disease other than COVID-19.
Mohamed Eltayieb Elawad, Abrar Bakry Elmalik, Doaa Mohamed Ahmed Hassan, Fatima Salaheldin Ibrahim Mohammed, Onaisa Hassan Kabroun Idris, Nasreen Sulaiman Omar Abdulaziz, Ibrahim A Ali   +6 more
doaj  

Microbiologically influenced corrosion in aluminium alloys and premier techniques for comprehensive identification and characterization across diverse metal types

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Microbiologically influenced corrosion (MIC) is acknowledged as a significant type of corrosion due to its extensive impact on metal/alloy surfaces. As MIC accounts for 20% of all corrosion instances, it is a critical factor causing service failure of engineering materials such as steel and aluminium alloy.
Brinda, M S Divyashree, Suma A Rao, Padmalatha Rao, Lavanya Mulky   +4 more
wiley   +1 more source

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, EarlyView.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients

Open Medicine, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is now a serious public health problem. Angiotensin-converting enzyme 2 (ACE2) recognized as the receptor of SARS-CoV is also necessary for SARS-CoV-2.
Ren Peng, Gong Caifeng, Ma Shaohua
doaj   +1 more source

SARS-CoV-2 mortality in blacks and temperature-sensitivity to an angiotensin-2 receptor blocker [PDF]

arXiv, 2020
Tropical climates provoke adaptations in skin pigmentation and in mechanisms controlling the volume, salt-content and pressure of body fluids. For many whose distant ancestors moved to temperate climes, these adaptations proved harmful: pigmentation decreased by natural selection and susceptibility to hypertension emerged.
arxiv