Results 11 to 20 of about 149,286 (348)

Association Between ACE2 and Lung Diseases

Infection and Drug Resistance
Cheng Su,1,* Cai Li,2,* Xinyi Hu,3,* Jing Wang,1,* Linlin Liu,4,* Xianfeng Zhang,4 Yeqing Tong4 1School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Infectious Disease ...
Su C, Li C, Hu X, Wang J, Liu L, Zhang X, Tong Y   +6 more
doaj   +3 more sources

Effects of Exercise on ACE2 [PDF]

Obesity, 2020
In addition to obesity, conditions that are typically associated with lower physical activity (higher age, hypertension, diabetes, coronary heart disease, and chronic obstructive pulmonary disease) are associated with worse clinical outcomes from COVID-19 (2) [ ]neither vaccines nor effective and safe pharmacotherapies against the novel severe acute
Klöting, Nora, Ristow, Michael, Blüher, Matthias   +2 more
openaire   +4 more sources

Genetic Landscape of the ACE2 Coronavirus Receptor [PDF]

Circulation, 2022
Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory ...
Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N, Ning Z, Zheng C, Wang Y, Huang T, He Y, Guo H, Ying K, Gustafsson S, Prins B, Ramisch A, Dermitzakis ET, Png G, Eriksson N, Haessler J, Hu X, Zanetti D, Boutin T, Hwang SJ, Wheeler E, Pietzner M, Raffield LM, Kalnapenkis A, Peters JE, Viñuela A, Gilly A, Elmståhl S, Dedoussis G, Petrie JR, Polašek O, Folkersen L, Chen Y, Yao C, Võsa U, Pairo-Castineira E, Clohisey S, Bretherick AD, Rawlik K, GenOMICC Consortium†, IMI-DIRECT Consortium†, Esko T, Enroth S, Johansson Å, Gyllensten U, Langenberg C, Levy D, Hayward C, Assimes TL, Kooperberg C, Manichaikul AW, Siegbahn A, Wallentin L, Lind L, Zeggini E, Schwenk JM, Butterworth AS, Michaëlsson K, Pawitan Y, Joshi PK, Baillie JK, Mälarstig A, Reiner AP, Wilson JF, Shen X   +70 more
openaire   +14 more sources

ACE2, Metformin, and COVID-19 [PDF]

iScience, 2020
COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19.
Malhotra, Atul, Hepokoski, Mark, McCowen, Karen C, Shyy, John Y-J   +3 more
openaire   +5 more sources

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

International Journal of Oral Science, 2020
It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection.
Hao Xu, L. Zhong, Jia-Qi Deng, Jiakuan Peng, H. Dan, Xin Zeng, Taiwen Li, Qianming Chen   +7 more
semanticscholar   +1 more source

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

Science, 2022
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo–electron microscopy (cryo-EM) structural analysis of the Omicron variant spike
D. Mannar, J. Saville, Xing Zhu, S. S. Srivastava, A. Berezuk, Katharine S. Tuttle, A. Márquez, Inna Sekirov, S. Subramaniam   +8 more
semanticscholar   +1 more source

ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa

International Journal of Molecular Sciences, 2022
Angiotensin-converting enzyme 2 (ACE2) is a protein widely expressed in numerous cell types, with different biological roles mainly related to the renin-angiotensin system. Recently, ACE2 has been in the spotlight due to its involvement in the SARS-CoV-2 entry into cells.
Ramal-Sanchez Marina, Castellini C., Cimini C., Taraschi A., Valbonetti L., Barbonetti A., Bernabò Nicola, Barboni B.   +7 more
openaire   +3 more sources

ACE2

, 2023
Official Full Name angiotensin I converting enzyme 2 Background The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin
openaire   +2 more sources

Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]

, 2020
Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core   +1 more source

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Intensive Care Medicine, 2020
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in Wuhan, China, in December 2019. The disease (COVID-19) spread rapidly, reaching epidemic proportions in China, and has been found in 27 ...
Haibo Zhang, J. Penninger, Yimin Li, N. Zhong, Arthur S Slutsky   +4 more
semanticscholar   +1 more source