Results 11 to 20 of about 77,670 (298)

Pharmacologic modulation of ACE2 expression [PDF]

Current Hypertension Reports, 2008
Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic
María José Soler, Clara Barrios, Raymond Oliva, Daniel Batlle   +3 more
openalex   +5 more sources

Genetic Landscape of the ACE2 Coronavirus Receptor [PDF]

Circulation, 2022
Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory ...
Yang, Z, MacDonald-Dunlop, E, Chen, J, Zhai, R, Li, T, Richmond, A, Klaric, L, Pirastu, N, Ning, Z, Zheng, C, Wang, Y, Huang, T, He, Y, Guo, H, Ying, K, Gustafsson, S, Prins, B, Ramisch, A, Dermitzakis, ET, Png, G, Eriksson, N, Haessler, J, Hu, X, Zanetti, D, Boutin, T, Hwang, S-J, Wheeler, E, Pietzner, M, Raffield, LM, Kalnapenkis, A, Peters, JE, Viñuela, A, Gilly, A, Elmståhl, S, Dedoussis, G, Petrie, JR, Polašek, O, Folkersen, L, Chen, Y, Yao, C, Võsa, U, Pairo-Castineira, E, Clohisey, S, Bretherick, AD, Rawlik, K, Esko, T, Enroth, S, Johansson, Å, Gyllensten, U, Langenberg, C, Levy, D, Hayward, C, Assimes, TL, Kooperberg, C, Manichaikul, AW, Siegbahn, A, Wallentin, L, Lind, L, Zeggini, E, Schwenk, JM, Butterworth, AS, Michaëlsson, K, Pawitan, Y, Joshi, PK, Baillie, JK, Mälarstig, A, Reiner, AP, Wilson, JF, Shen, X, GenOMICC Consortium and the IMI-DIRECT Consortium   +69 more
openaire   +9 more sources

Effects of Exercise on ACE2 [PDF]

Obesity, 2020
In addition to obesity, conditions that are typically associated with lower physical activity (higher age, hypertension, diabetes, coronary heart disease, and chronic obstructive pulmonary disease) are associated with worse clinical outcomes from COVID-19 (2) [ ]neither vaccines nor effective and safe pharmacotherapies against the novel severe acute
Klöting, Nora, Ristow, Michael, Blüher, Matthias   +2 more
openaire   +4 more sources

ACE and ACE2: a tale of two enzymes [PDF]

European Heart Journal, 2005
This editorial refers to ‘Myocardial infarction increases ACE2 expression in rat and humans’† by Burrell et al. , on page 369 The cardiac renin–angiotensin–aldosterone system (RAAS) is an endocrine cascade, which results in the conversion of the inactive pro-hormone angiotensin I (Ang I) to the active peptide hormone Ang II, and may also function as ...
Lawrence S. Zisman
openalex   +4 more sources

ACE2 alterations in kidney disease [PDF]

Nephrology Dialysis Transplantation, 2013
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney
María José Soler, Jan Wysocki, Daniel Batlle   +2 more
openalex   +5 more sources

ACE2, Metformin, and COVID-19 [PDF]

iScience, 2020
COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19.
Malhotra, Atul, Hepokoski, Mark, McCowen, Karen C, Shyy, John Y-J   +3 more
openaire   +6 more sources

ACE2 Activation Promotes Antithrombotic Activity [PDF]

The FASEB Journal, 2010
Hyperactivity of the axis ACE/AngII/AT1R of the renin‐angiotensin system is associated with occurrence of acute thrombotic event. Recently a novel concept of a counterrugulatory axis, ACE2/Ang‐(1‐7)/Mas, has emerged. We hypothesized that ACE2 would be protective against thrombosis.
Rodrigo A. Fraga-Silva, Brian S. Sorg, Mamta Wankhede, Casey deDeugd, Joo Yun Jun, Matthew B. Baker, Yan Li, Ronald K. Castellano, Michael J. Katovich, Mohan K. Raizada, Anderson J. Ferreira   +10 more
openalex   +5 more sources

ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa

International Journal of Molecular Sciences, 2022
Angiotensin-converting enzyme 2 (ACE2) is a protein widely expressed in numerous cell types, with different biological roles mainly related to the renin-angiotensin system. Recently, ACE2 has been in the spotlight due to its involvement in the SARS-CoV-2 entry into cells.
Ramal-Sanchez Marina, Castellini C., Cimini C., Taraschi A., Valbonetti L., Barbonetti A., Bernabò Nicola, Barboni B.   +7 more
openaire   +3 more sources

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

Review of using saliva for COVID-19 testing

Scientific Dental Journal, 2022
Saliva is a hypotonic solution of gingival, salivary acini, and exudate sulcus fluid from the oral mucosa. Saliva contains proteins, DNA, RNA, micro-RNA, and metabolites; hence, it can be detected early in viruses, bacteria, as well as systemic diseases.
Jessica Endriyana, Endang Winiati Bachtiar   +1 more
doaj   +1 more source