Results 21 to 30 of about 77,670 (298)
The therapeutic potential of the novel angiotensin-converting enzyme 2 in the treatment of coronavirus disease-19 [PDF]
Veterinary World, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). This virus has become a global pandemic with unprecedented mortality and morbidity along with attendant financial and economic ...
Ademola Adetokunbo Oyagbemi +21 more
doaj +1 more source
Clinical Science, 2020 Abstract The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance.
Li, Qiuhong +3 more
openaire +2 more sources
BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock +3 more
wiley +1 more source
Инфекция и иммунитет, 2020 COVID-19 is a zoonotic disease that showed higher levels of transmissibility in humans. Coronavirus has the largest recognized genome (28–33 kb) of a positive-sense single stranded RNA.
F. A. Isihak, M. A. Hamad, N. G. Mustafa
doaj +1 more source
Metabolic Syndrome “Interacts” With COVID-19
BIO Integration, 2021 COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emerged as a global pandemic and poses a great threat to public health and society in general.
Zeling Guo +3 more
doaj +1 more source
Molecular docking study and mapping the binding site of some antiviral nanobodies against receptor binding domain (RBD) of SARS-COV 2 [PDF]
Nanochemistry Research, 2021 Neutralization ability of some antiviral nanobodies was computed against the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2).
zahra pahlavan, Mohammad Hossein Fatemi
doaj +1 more source
Accurate Evaluation on the Interactions of SARS-CoV-2 with Its Receptor ACE2 and Antibodies CR3022/CB6 [PDF]
CHIN.PHYS.LETT. Vol.38, No.1(2021)018701 Express Letter, 2021 The spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health crisis. The binding affinity of SARS-CoV-2 (in particular the receptor binding domain, RBD) to its receptor angiotensin converting enzyme 2 (ACE2) and the antibodies is of great importance in ...
arxiv +1 more source
Manipulation of ACE2 expression in COVID-19 [PDF]
Open Heart, 2020 SARS-CoV-2 is the virus responsible for the ongoing COVID-19 outbreak. The virus uses ACE2 receptor for viral entry. ACE2 is part of the counter-regulatory renin-angiotensin-aldosterone system and is also expressed in the lower respiratory tract along the alveolar epithelium.
Chaudhry, Farhan +7 more
openaire +4 more sources
Type 1 diabetes recurrence after SARS‐CoV‐2 infection in a subject with pancreas transplantation
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 During COVID‐19 pandemic, several studies have demonstrated a strong link between SARS‐CoV2 infection and diabetes mellitus. Little is known about the effects of SARS‐CoV‐2 infection on glycaemic control in pancreas transplant patients. Abstract Background During COVID‐19 pandemic, several studies have demonstrated a strong link between SARS‐CoV‐2 ...
Valentina Popolla +4 more
wiley +1 more source
Resveratrol supplementation reduces ACE2 expression in human adipose tissue
Adipocyte, 2021 Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 ...
Marlies de Ligt +5 more
doaj +1 more source