Results 21 to 30 of about 149,286 (348)

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

Nature Communications, 2021
The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the ACE2 receptor and is cleaved by TMPRSS2.
S. Ozono, Yan-Zhong Zhang, H. Ode, K. Sano, Toong Seng Tan, K. Imai, K. Miyoshi, S. Kishigami, T. Ueno, Y. Iwatani, Tadaki Suzuki, K. Tokunaga   +11 more
semanticscholar   +1 more source

ACE2 as therapeutic agent

Clinical Science, 2020
Abstract The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance.
Li, Qiuhong, Grant, Maria B., Richards, Elaine M., Raizada, Mohan K.   +3 more
openaire   +2 more sources

Evolutionary Analysis of Mammalian ACE2 and the Key Residues Involved in Binding to the Spike Protein Revealed Potential SARS-CoV-2 Hosts

Journal of Medical Microbiology and Infectious Diseases, 2022
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) spilled over to humans via wild mammals, entering the host cell using angiotensin-converting enzyme 2 (ACE2) as receptor through Spike (S) protein binding.
Luciano Rodrigo Lopes1, Natália Carvalho de Lucca Pina1, Antonio Carlos da Silva Junior1, Paulo- Bandiera Paiva1   +3 more
doaj   +1 more source

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Frontiers in Medicine, 2020
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2).
Xin Zou, Ke Chen, Jiawei Zou, Pei-jun Han, Jie Hao, Ze-Guang Han   +5 more
semanticscholar   +1 more source

ACE2 alterations in kidney disease [PDF]

Nephrology Dialysis Transplantation, 2013
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney
María José, Soler, Jan, Wysocki, Daniel, Batlle   +2 more
openaire   +2 more sources

Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?

Clinical and Experimental Hypertension, 2022
Background: ACE2, a component of the non-classic renin-angiotensin system (RAS), acts as a functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) spike protein, which enables the entry of the virus into the host cells.
Shakhi Shylesh C.M, Arya V S, Kanthlal S. K., Uma Devi P.   +3 more
doaj   +1 more source

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

European Journal of Clinical Microbiology and Infectious Diseases, 2021
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell surfaces through which SARS-CoV-2 enters the host cells and is highly expressed in the ...
Stephany Beyerstedt, E. B. Casaro, É. B. Rangel   +2 more
semanticscholar   +1 more source

Impact of COVID-19 in field of Dentistry

Revista Información Científica, 2023
Introduction: COVID-19 is a disease caused by SARS-CoV-2 virus and transmitted through respiratory track. So, dentists face a great risk working directly in the oral cavity. Objective: systematization of the theoretical references concerning the impact
Karen Estefanny Alvarez-Freire, Gabriela Liseth Vaca-Altamirano, José Arturo Molina-Ramón, Lisbeli Cantillo-Acosta   +3 more
doaj   +1 more source

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Allen, James M., Baker, Andrew H., Chamberlain, Jeffrey S., Craig, Margaret Anne, Dominiczak, Anna F., Gilday, Kirsten, Graham, Delyth, Gregorevic, Paul, Masson, Rachel, McBride, Martin, Napoli, Claudio, Nicklin, Stuart A., Smith, Godfrey   +12 more
core   +1 more source

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

Infectious Diseases of Poverty, 2020
Since its discovery in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has caused more than 150 000 deaths as of April 16, 2020.
Mengyuan Li, Lin Li, Yue Zhang, Xiaosheng Wang   +3 more
semanticscholar   +1 more source