Results 61 to 70 of about 149,286 (348)

Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]

, 2011
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet, Amberg, Sean M, Chen, Yen Ting, Craik, Charles S, Goetz, David H, Hansell, Elizabeth, Lu, Kai, McKerrow, James, Roush, William R, Simmons, Graham, Zhou, Yanchen   +10 more
core   +1 more source

Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov

bioRxiv, 2020
A novel coronavirus (2019-nCov) was identified in Wuhan, Hubei Province, China in December of 2019. This new coronavirus has resulted in thousands of cases of lethal disease in China, with additional patients being identified in a rapidly growing number ...
Yu Zhao, Zixian Zhao, Yujia Wang, Yueqing Zhou, Yu Ma, Wei Zuo   +5 more
semanticscholar   +1 more source

Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody

Science, 2022
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant infective strain. We report the structures of the Omicron spike trimer on its own and in complex with angiotensin-converting enzyme 2 (ACE2) or an ...
W. Yin, Youwei Xu, P. Xu, Xiaodan Cao, Canrong Wu, Chun-xia Gu, Xinheng He, Xiaoxi Wang, Sijie Huang, Qingning Yuan, Kai Wu, Wen-juan Hu, Zifu Huang, Jia Liu, Zongda Wang, Fang-Yuan Jia, K. Xia, Peipei Liu, Xueping Wang, Bin Song, Jie Zheng, Hualiang Jiang, Xi Cheng, Yi Jiang, S. Deng, H. Xu   +25 more
semanticscholar   +1 more source

Cessation of Renin-Angiotensin System Antagonists During the SARS-CoV-2 Pandemic – Do We Have the Evidence?

Journal of Interdisciplinary Medicine, 2020
The aim of this review is to provide a short update on whether treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) has beneficial or harmful effects in patients infected with SARS-CoV-2. Epidemiological
Blîndu Emanuel, Gerculy Renata, Opincariu Diana, Cernica Daniel, Benedek Imre   +4 more
doaj   +1 more source

Therapeutic potential of the renin angiotensin system in ischaemic stroke [PDF]

, 2016
The renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e.
Arroja, Mariana Moreira Coutinho, McCabe, Christopher, Reid, Emma   +2 more
core   +1 more source

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

Cardiovascular Research, 2020
A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients ...
Liang Chen, Xiangjie Li, Mingquan Chen, Yi Feng, C. Xiong   +4 more
semanticscholar   +1 more source

ACE2 pathway regulates thermogenesis and energy metabolism [PDF]

eLife, 2021
Identification of key regulators of energy homeostasis holds important therapeutic promise for metabolic disorders, such as obesity and diabetes. ACE2 cleaves angiotensin II (Ang II) to generate Ang-(1-7) which acts mainly through the Mas1 receptor.
Chuan-Hai Zhang, Ting-Ting Shi, Xi Cao, Wan-Zhu Jin, Li-Ni Song, Yi-Chen Zhang, Jing-Yi Liu, Fang-Yuan Yang, Charles N Rotimi, Aimin Xu, Jin-Kui Yang   +10 more
openaire   +3 more sources

The importance of smell and taste in everyday life: Dysfunction in COVID-19 patients [PDF]

Medicinski Podmladak, 2021
Human-to-human transmission of coronavirus (SARS-CoV-2) - COVID-19 (corona virus disease 2019) - is characterized by a pandemic exponential rate and the patients with mild to moderate infection have odor and taste problems that represent a new atypical ...
Stanojlović Olivera
doaj   +1 more source

The protein expression profile of ACE2 in human tissues

bioRxiv, 2020
The novel SARS-coronavirus 2 (SARS-CoV-2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS-CoV-2 infection, the cell type-specific expression of the host cell surface receptor is necessary. The key protein
Feria Hikmet, Loren Méar, Å. Edvinsson, P. Micke, M. Uhlén, C. Lindskog   +5 more
semanticscholar   +1 more source

Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC

Journal of Inflammation Research, 2021
Wuping Bao,1,* Xue Zhang,1,* Yubiao Jin,2,* Huijuan Hao,1 Fu Yang,3 Dongning Yin,1 Xi Chen,3 Yishu Xue,1 Lei Han,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of ...
Bao W, Zhang X, Jin Y, Hao H, Yang F, Yin D, Chen X, Xue Y, Han L, Zhang M   +9 more
doaj