Results 61 to 70 of about 77,670 (298)
The New SARS-CoV-2 Strain Shows a Stronger Binding Affinity to ACE2 Due to N501Y Mutation [PDF]
arXiv, 2021 SARS-CoV-2 is a global challenge due to its ability to spread much faster than SARS-CoV, which was attributed to the mutations in the receptor binding domain (RBD). These mutations enhanced the electrostatic interactions. Recently, a new strain was reported in the UK that includes a mutation (N501Y) in the RBD, that possibly increases the infection ...
arxiv
In silico study of intrinsic dynamics of full-length apo-ACE2 and RBD-ACE2 complex
Computational and Structural Biotechnology Journal, 2021 The key step for SARS-CoV-2 to infect human cells is the membrane fusion triggered by the binding of the viral extracellular Spike protein to the human extracellular receptor, the angiotensin-converting enzyme 2 (ACE2). Although the Cryo-electron microscopy (Cryo-EM) uncovered the static atomic details of ACE2 homodimers, there is still a lack of ...
Qing Liu +3 more
openaire +3 more sources
ACE2 and COVID-19 and the resulting ARDS [PDF]
Postgraduate Medical Journal, 2020 AbstractThis article reviews the correlation between ACE2 and COVID-19 and the resulting acute respiratory distress syndrome (ARDS). ACE2 is a crucial component of the renin-angiotensin system (RAS). The classical ACE-angiotensin Ⅱ (Ang II)-angiotensin type 1 receptor (AT1R) axis and the ACE2-Ang(1-7)-Mas counter-regulatory axis play an essential role ...
Zhang, Xiaoqing +2 more
openaire +2 more sources
Study on the Clinical Significance of ACE2 and Its Age-Related Expression
Journal of Inflammation Research, 2021 Jie Gu,1,* JiangWen Yin,1,* MengJie Zhang,1,* JinHui Li,1 YeMing Wu,2 Jun Chen,1 HongJun Miao1 1Department of Emergency/Critical care Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210008, People’s ...
Gu J +6 more
doaj
The Use of ACE inhibitor/ARB in SARS-CoV-2 Patients: A Comprehensive Narrative Review
Asian Journal of Medical Sciences, 2020 The three most common comorbidities that are associated with increased mortality in COVID-19 patients are Hypertension, Diabetes, and Cardiovascular disease, Angiotensin-converting enzyme (ACE) inhibitors and Angiotensin II receptor blockers (ARB) are ...
Timotius Ivan Hariyanto +5 more
doaj +1 more source
SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases
Journal of Inflammation Research, 2021 Avaniyapuram Kannan Murugan,1 Ali S Alzahrani1,2 1Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia; 2Department of Medicine, King Faisal Specialist ...
Murugan AK, Alzahrani AS
doaj
Insights into the COVID-19 pandemic: Origin, pathogenesis, diagnosis, and therapeutic interventions
Frontiers in Bioscience-Elite, 2020 Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the human coronavirus (HCoV) family that targets the lower part of the respiratory tract and causes severe acute respiratory syndrome ...
Mahmoud M. Berekaa
doaj +1 more source
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications [PDF]
Science Signaling 12 Jan 2021: Vol. 14, Issue 665, eabd0334, 2020 The primary cell surface receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2). Recently it has been noticed that the viral Spike protein has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented with ...
arxiv +1 more source
Bridging Cancer and COVID-19: The Complex Interplay of ACE2 and TMPRSS2. [PDF]
Cancer MedACE2 and TMPRSS2 not only mediate SARS‐CoV‐2 infection may also be involved in cancer progression (such as affecting tumor proliferation, matastasis or immune infiltration), and they can be used as targets to treat cancer patients infected with SARS‐CoV‐2.
Tang X, Lu L, Li X, Huang P.
europepmc +2 more sources
Impact of COVID-19 in field of Dentistry
Revista Información Científica, 2023 Introduction: COVID-19 is a disease caused by SARS-CoV-2 virus and transmitted through respiratory track. So, dentists face a great risk working directly in the oral cavity. Objective: systematization of the theoretical references concerning the impact
Karen Estefanny Alvarez-Freire +3 more
doaj +1 more source