Results 71 to 80 of about 77,670 (298)

The SARS-CoV-2 Spike Protein is vulnerable to moderate electric fields [PDF]

, 2021
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target [1-3]. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for virus entry. During this process, the receptor binding domain (RBD)
arxiv   +1 more source

Progress in COVID research and developments during pandemic

VIEW, Volume 3, Issue 6, December 2022., 2022
The pandemic respiratory disease COVID‐19 has spread over the globe within a small span of time. Generally, there are two important points are being highlighted and considered towards the successful diagnosis and treatment process. The first point includes the reduction of the rate of infections and the next one is the decrease of the death rate.
Sudheesh K. Shukla, Santanu Patra, Trupti R. Das, Dharmesh Kumar, Anshuman Mishra, Ashutosh Tiwari   +5 more
wiley   +1 more source

ACE2 and gut amino acid transport

Clinical Science, 2020
Abstract ACE2 is a type I membrane protein with extracellular carboxypeptidase activity displaying a broad tissue distribution with highest expression levels at the brush border membrane (BBM) of small intestine enterocytes and a lower expression in stomach and colon.
C. Meier, Simone M. R. Camargo, Raphael N. Vuille-dit-Bille, Raphael N. Vuille-dit-Bille, François Verrey   +4 more
openaire   +3 more sources

SARS‐CoV‐2 infection of companion animals in Egypt and its risk of spillover

Veterinary Medicine and Science, Volume 9, Issue 1, Page 13-24, January 2023., 2023
Graphical abstract depicts SARS‐CoV‐2 spillover in humans and their pet animals with common symptoms. Besides, it illustrates number of SARS‐CoV‐2‐infected cats and dogs with severity of respiratory signs. Abstract Background Reverse zoonoses occur because of interactions between humans and animals.
Mervat E. Hamdy, Ayman H. El‐Deeb, Naglaa M. Hagag, Momtaz A. Shahein, Namal P. M. Liyanage, Mohamed Shalaan, Hussein A. Hussein   +6 more
wiley   +1 more source

Combining VEGF receptor inhibitors and angiotensin-(1–7) to target renal cell carcinoma

Molecular & Cellular Oncology, 2021
Resistance to tyrosine kinase inhibitors of the vascular endothelial growth factor receptor inevitably develops in most patients with metastatic kidney cancer.
Thomas Walther, Prateek Khanna, Rupal S. Bhatt   +2 more
doaj   +1 more source

The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity

EXCLI Journal : Experimental and Clinical Sciences, 2022
Genes involved in the regulation of viral recognition and its entry into a host cell have been identified as candidates for genetic association studies on COVID-19 severity.
Zorana Dobrijević, Dragana Robajac, Nikola Gligorijević, Miloš Šunderić, Ana Penezić, Goran Miljuš, Olgica Nedić   +6 more
doaj   +1 more source

ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery

Clinical Science, 2020
Abstract Angiotensin-converting enzyme II (ACE2) is a homologue of angiotensin-converting enzyme discovered in 2000. From the initial discovery, it was recognized that the kidneys were organs very rich on ACE2. Subsequent studies demonstrated the precise localization of ACE2 within the kidney and the importance of this enzyme in the ...
Lores, Enrique, Wysocki, Jan, Batlle, Daniel   +2 more
openaire   +2 more sources

Molecular screening of SARS‐CoV‐2 in dogs and cats from households with infected owners diagnosed with COVID‐19 during Delta and Omicron variant waves in Iran

Veterinary Medicine and Science, Volume 9, Issue 1, Page 82-90, January 2023., 2023
• SARS‐CoV‐2 was detected in 2 cats out of 20 examined (10%). • SARS‐CoV‐2 was not detected in dog samples. • The two cats positive for SARS‐CoV‐2 had clinical signs and were in close contact with COVID‐19 positive owners. Abstract Objective The emergence of SARS‐CoV‐2 infection in dogs and cats in different countries worldwide raises concerns that ...
Baharak Akhtardanesh, Maziar Jajarmi, Mohammadreza Shojaee, Sina Salajegheh Tazerji, Maziar Khalili Mahani, Pouneh Hajipour, Rasha Gharieb   +6 more
wiley   +1 more source

Protective effects of melatonin on AT1, ACE2, and Mas genes expression in induced diabetic aortic rats [PDF]

Iraqi Journal of Veterinary Sciences
Diabetes mellitus (DM) is considered a threat to the vascular tone. Melatonin (MEL) exhibits broad-spectrum effects across multiple organs and displays pleiotropic characteristics.
Nazar M. Mahmood, Almas M. Mahmud, Ismail M. Maulood   +2 more
doaj   +1 more source

Association of ACEI/ARB, inflammatory cytokines, and antiviral drugs with liver dysfunction in patients with hypertension and COVID-19

Clinical and Experimental Hypertension, 2021
Background: Currently, SARS-CoV-2 liver invasion, inflammatory cytokines, and antiviral drugs are widely thought to be associated with liver dysfunction in COVID-19 patients.
Dong Xiang, Xiuhua Ren, Qian Chen, Hengyi Yu, Xiping Li, Dong Liu   +5 more
doaj   +1 more source