Results 71 to 80 of about 149,286 (348)

Schizosaccharomyces pombe Pol II transcription elongation factor ELL functions as part of a rudimentary super elongation complex [PDF]

, 2018
ELL family transcription factors activate the overall rate of RNA polymerase II (Pol II) transcription elongation by binding directly to Pol II and suppressing its tendency to pause.
Alonso-Nunez, Bahler, Bahler, Banks, Buchan, Cairns, Charles AS Banks, Chou, Christopher W Seidel, Coudreuse, Dana M Gibbon, Elmendorf, Florens, Garg, He, He, Joan W Conaway, Kim, Kimura, Kimura, Kitts, Kong, Langmead, Laurence A Florens, Li, Lin, Luo, Luo, Michael P Washburn, Miller, Monahan, Nimisha Sharma, Oliva, Preeti Dabas, Quinlan, Robinson, Ronald C Conaway, Rustici, Shilatifard, Shilatifard, Simone, Simone, Sneha Gopalan, Sobhian, Suarez, Szklarczyk, Tabb, Takahashi, Thorvaldsdottir, Tsai, Ward, Washburn, Ying Zhang, Yokoyama, Zhang   +54 more
core   +1 more source

Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Aging and Disease, 2020
A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19) outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to save the patients with severe COVID-19 pneumonia.
Zikuan Leng, Rongjia Zhu, W. Hou, Yingmei Feng, Yanlei Yang, Q. Han, G. Shan, F. Meng, Dongshu Du, Shihua Wang, Junfen Fan, Wenjing Wang, Luchan Deng, Hongbo Shi, Hongjun Li, Zhongjie Hu, Fengchun Zhang, Jinming Gao, Hongjian Liu, Xiaoxia Li, Yangyang Zhao, Kan Yin, Xijing He, Zhengchao Gao, Yibin Wang, Bo Yang, R. Jin, I. Stambler, L. Lim, Huanxing Su, A. Moskalev, A. Cano, S. Chakrabarti, K. Min, G. Ellison‐Hughes, C. Caruso, K. Jin, R. Zhao   +37 more
semanticscholar   +1 more source

ACE2 and Microbiota [PDF]

Journal of Cardiovascular Pharmacology, 2015
The health of the cardiovascular and pulmonary systems is inextricably linked to the renin-angiotensin system (RAS). Physiologically speaking, a balance between the vasodeleterious (Angiotensin-converting enzyme [ACE]/Angiotensin II [Ang II]/Ang II type 1 receptor [AT1R]) and vasoprotective (Angiotensin-converting enzyme 2 [ACE2]/Angiotensin-(1-7) [Ang-
Colleen T, Cole-Jeffrey, Meng, Liu, Michael J, Katovich, Mohan K, Raizada, Vinayak, Shenoy   +4 more
openaire   +2 more sources

Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]

, 2015
Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo, Stergiopulos, Nikolaos, Trachet, Bram   +2 more
core   +2 more sources

COVID-19, ACE2, and the cardiovascular consequences

American Journal of Physiology. Heart and Circulatory Physiology, 2020
The novel SARS coronavirus SARS-CoV-2 pandemic may be particularly deleterious to patients with underlying cardiovascular disease (CVD). The mechanism for SARS-CoV-2 infection is the requisite binding of the virus to the membrane-bound form of ...
A. South, D. Diz, M. Chappell
semanticscholar   +1 more source

Correlations of gene polymorphisms of angiotensin-converting enzyme 2 with onset and prognosis of hypertrophic cardiomyopathy [PDF]

Journal of Medical Biochemistry
Background: To investigate the correlations of the gene polymorphisms of angiotensin-converting enzyme 2 (ACE2) with the onset and prognosis of hypertrophic cardiomyopathy (HCM), so as to provide references for the early prevention and precise treatment ...
Li Sujuan, Lin Xizhi, Ye Haoting, Li Biyun, Zeng Siyu, Mei Qinghua, Huang Yukai, Liu Yixuan   +7 more
doaj   +1 more source

Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a major pandemic that threatens millions of human lives and the global economy.
Joana Damas, Graham M. Hughes, Kathleen C. Keough, C. Painter, N. Persky, Marco Corbo, M. Hiller, Klaus‐Peter Koepfli, Andreas R. Pfenning, Huabin Zhao, D. Genereux, Ross Swofford, K. Pollard, O. Ryder, M. Nweeia, K. Lindblad-Toh, E. Teeling, E. Karlsson, H. Lewin   +18 more
semanticscholar   +1 more source

COVID-19 Induced Cytokine Storm and the Impact of Obesity and Vitamin D Deficiency [PDF]

Journal of Krishna Institute of Medical Sciences University, 2021
Recent studies on Coronavirus Disease 2019 (COVID-19) have shown that obesity and vitamin D deficiency increase the risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2) infection and its complications. The levels of cytokines are increased
Shobha Chikkavaddaragudi Ramachandra, Akila Prashant, Prashant Vishwanath   +2 more
doaj  

Association of ACEI/ARB, inflammatory cytokines, and antiviral drugs with liver dysfunction in patients with hypertension and COVID-19

Clinical and Experimental Hypertension, 2021
Background: Currently, SARS-CoV-2 liver invasion, inflammatory cytokines, and antiviral drugs are widely thought to be associated with liver dysfunction in COVID-19 patients.
Dong Xiang, Xiuhua Ren, Qian Chen, Hengyi Yu, Xiping Li, Dong Liu   +5 more
doaj   +1 more source

The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity

EXCLI Journal : Experimental and Clinical Sciences, 2022
Genes involved in the regulation of viral recognition and its entry into a host cell have been identified as candidates for genetic association studies on COVID-19 severity.
Zorana Dobrijević, Dragana Robajac, Nikola Gligorijević, Miloš Šunderić, Ana Penezić, Goran Miljuš, Olgica Nedić   +6 more
doaj   +1 more source