Results 201 to 210 of about 116,538 (267)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Active Colitis Attenuates Ventricular Excitation-Contraction Coupling by T-Tubular Remodeling. [PDF]

Biomolecules
Ouille V EJ, Pereira CH, Marinho Y, Kanaporis G, Banach K.   +4 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mild hypothermia alleviates post-resuscitation cerebral injury in rats via modulating the balance of the renin-angiotensin system. [PDF]

Resusc Plus
He Y, Wu Q, Huang S, Wu D, Zhan Y, Deng J, Xu B, Xie L, Zheng J.   +8 more
europepmc   +1 more source

Methyl Palmitate, a Potent Angiotensin Converting Enzyme Inhibitor, Attenuates Vascular Remodeling in L-N^G-Nitro Arginine Methyl Ester-Induced Hypertensive Wistar Rat Models.

J Vasc Res
Rao A, Udupa P, Rhea Lewis C, Yelleti G.
europepmc   +1 more source

AI-empowered clinical evidence for integrated Chinese-Western medicine: Introduction to the ACE-iMed series and platform dissemination. [PDF]

Integr Med Res
Yu X, Ma Y, Luo X, Chen Y, Bian Z.
europepmc   +1 more source

The joint-local renin-angiotensin system in rheumatoid arthritis and osteoarthritis: mechanistic evidence, disease-specific patterns, and translational perspectives. [PDF]

Rheumatol Int
Bilgin E, Haznedaroğlu İC.
europepmc   +1 more source

Characterization of the myocardial and renal renin-angiotensin system in normal cats and cats with hypertrophic cardiomyopathy. [PDF]

J Vet Intern Med
Wood JE, Ames MK, Kaplan JL, Rivas V, Wilson MD, Domenig O, Stern JA.   +6 more
europepmc   +1 more source

Effects of 12-week aquatic HIIT on blood pressure lipid profile and BaPWV in postmenopausal women with different ACE genotypes. [PDF]

Sci Rep
Zhou WS, Li YH, Xu N, Liu BF, Li ZH, Gu SJ, Zhang RY, Xuan-Xu, Yan C, Wang QY, Sun L, Gu M, Zhu TQ, Tian L.   +13 more
europepmc   +1 more source