Results 21 to 30 of about 116,538 (267)
Tissue-specific expression of transgenic secreted ACE in vasculature can restore normal kidney functions, but not blood pressure, of Ace-/- mice. [PDF]
PLoS ONE, 2014 Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions. All
Saurabh Chattopadhyay +5 more
doaj +1 more source
Tissue Angiotensin II Generating System by Angiotensin-Converting Enzyme and Chymase
Journal of Pharmacological Sciences, 2006 .: It had been believed that angiotensin II (Ang II) was produced by the renin-angiotensin system (RAS), which was established in the 1950’s. After a while, people realized that the multiple functions of Ang II could not be explained by the conventional ...
Mizuo Miyazaki, Shinji Takai
doaj +1 more source
Role of angiotensin-converting enzyme in myeloid cell immune responses
Cellular & Molecular Biology Letters, 2020 Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, plays a major role in the regulation of blood pressure by cleaving angiotensin I into angiotensin II (Ang II), a potent vasoconstrictor.
Duo-Yao Cao +7 more
doaj +1 more source
Pulmonary midkine inhibition ameliorates sepsis induced lung injury
Journal of Translational Medicine, 2021 Background Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) system, as well as the mechanism by ...
Jing-Yuan Xu +4 more
doaj +1 more source
Marine Drugs, 2021 Angiotensin-I-converting enzyme (ACE) is a crucial enzyme or receptor that catalyzes the generation of potent vasopressor angiotensin II (Ang II). ACE inhibitory peptides from fish showed effective ACE inhibitory activity.
Shuilin Cai +8 more
doaj +1 more source
Effects of ACE Inhibitors on Cardiac Angiotensin II and Aldosterone in Humans: “Relevance of Lipophilicity and Affinity for ACE” [PDF]
American Journal of Hypertension, 2010 Angiotensin-converting enzyme (ACE) inhibitors differ in their lipophilic/hydrophilic index that determines their tissue bioavailability and affinity to ACE, which may result in major differences in the degree of blockade of cardiac ACE. We evaluated the hypothesis that in patients with chronic heart failure (CHF) and activated cardiac renin ...
Marcel, Ruzicka +5 more
openaire +2 more sources
POLYMORPHISM IN THE ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE AND ACE ACTIVITY IN TYPE 2 DIABETIC PATIENTS [PDF]
Acta Medica Iranica, 2008 "nDiabetes mellitus is a multifactorial disease. It has recently been shown that an insertion (I)/deletion (D) polymorphism exists in the angiotensin-converting enzyme (ACE) gene that can affect the serum ACE level. There are three genotypes: DD, DI,
A Nikzamir +4 more
doaj +2 more sources
The Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Modifies Exercise-Induced Muscle Metabolism. [PDF]
PLoS ONE, 2016 OBJECTIVE:A silencer region (I-allele) within intron 16 of the gene for the regulator of vascular perfusion, angiotensin-converting enzyme (ACE), is implicated in phenotypic variation of aerobic fitness and the development of type II diabetes.
David Vaughan +9 more
doaj +1 more source
PLoS ONE, 2014 ACE inhibitor drugs decrease mortality by up to one-fifth in cardiovascular patients. Surprisingly, there are reports dating back to 1979 suggesting the existence of endogenous ACE inhibitors.
Miklós Fagyas +8 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks +5 more
wiley +1 more source