Results 71 to 80 of about 69,918 (298)

Proteinuria in systemic sclerosis: reversal by ACE inhibition [PDF]

Rheumatology International, 2013
In systemic sclerosis (SSc), kidney damage is a major clinical problem which can lead to a deleterious outcome. Recently, in diabetes mellitus, early detection of proteinuria and treatment with angiotensin-converting enzyme (ACE) inhibitors has been shown to slow progression of kidney disease and to improve prognosis. In this study, we investigated the
Schuster, J., Moinzadeh, P., Kurschat, C., Benzing, T., Krieg, T., Weber, M., Hunzelmann, N.   +6 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Probing Angiotensin Converting Enzyme (ACE) Domain-Dependent Inhibition of Onopordia, Isolated from Onopordon acanthium L., Using a Continuous Fluorescent Assay [PDF]

Pharmaceutical Sciences, 2018
Background: Somatic ACE is a two-domain protein, C and N which are resulted from gene duplication. Presence of two active sites with particular properties, demonstrates functional significance of each domain.
Niusha Sharifi, Khosro Khajeh, Shabnam Mahernia, Saeed Balalaie, Ghasem Ataie, Raheleh Jahanbani, Massoud Amanlou   +6 more
doaj   +1 more source

Dual platelet inhibition in ACS - The Styrian consensus [PDF]

Cor et Vasa, 2013
AbstractDual antiplatelet therapy facilitated treatment of acute coronary syndromes and enabled the wide use of stents after clopidogrel emerged on the market about twenty years ago. Although this was a milestone in cardiology, clopidogrel inherits several disadvantages which are likely to reduce clinical benefit of its use and a new generation of ...
von Lewinski, Dirk, Schuchlenz, Herwig, Doppler, Reinhard, Wallner, Markus, Pieske, Burkert   +4 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Peptidomics-based identification of antihypertensive and antidiabetic peptides from sheep milk fermented using Limosilactobacillus fermentum KGL4 MTCC 25515 with anti-inflammatory activity: in silico, in vitro, and molecular docking studies

Frontiers in Chemistry
This study investigated the synthesis of bioactive peptides from sheep milk through fermentation with Limosilactobacillus fermentum KGL4 MTCC 25515 strain and assessed lipase inhibition, ACE inhibition, α-glucosidase inhibition, and α-amylase inhibition ...
Rinkal Pipaliya, Bethsheba Basaiawmoit, Amar A. Sakure, Ruchika Maurya, Ruchika Maurya, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Brij Pal Singh, Souparno Paul, Zhenbin Liu, Preetam Sarkar, Ashish Patel, Subrota Hati   +12 more
doaj   +1 more source

ACE inhibition scintigraphy in the management of hypertension in children

, 1999
Angiotensin converting enzyme (ACE) inhibition scintirenography was performed to help establish the diagnosis and plan treatment of renovascular hypertension (RVH) in 57 hypertensive pediatric patients, 33 infants and 24 children older than 1 year. In 16
Sfakianakis, G. N, Zilleruelo, Gaston E, Chandar, Jayanthi J, Strauss, Jose, Guerra, Jorge J, Abitbol, Carolyn L, Georgiou, Mike F, Montane, Brenda S   +7 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Johnston, F., Maguire, J.J., Maguire, Janet J., Seed, Alison, Hanka J. de Voogd, Essers, H., Janet J. Maguire, Kuc, R.E., de Voogd, H.J., Kuc, Rhoda E., Seed, A., McMurray, J.J.V., Davenport, Anthony P., Hillier, Christopher, Rhoda E. Kuc, Anthony P. Davenport, Hillier, C., Hans Essers, Davenport, A.P., Alison Seed, Johnston, Fiona, John McMurray, Christopher Hillier, McMurray, John, Fiona Johnston, Essers, Hans, de Voogd, Hanka J.   +26 more
core   +1 more source