Results 91 to 100 of about 1,205,174 (292)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

In Silico and In Vitro Screening and Mechanisms of Angiotensin I-Converting Enzyme Inhibitory Peptides from Protein Hydrolysates of Royal Jelly

Foods
This work focused on the identification of angiotensin I-converting enzyme (ACE) inhibitory peptides from royal jelly (RJ) proteins and elucidated their inhibition patterns and mechanisms.
Ying Zhang, Shipeng Guo, Haoxiang Miao, Yafei Gu, Jian Zhang   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]

, 1997
Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Weber, Christian, Messmer, Konrad, Habazettl, Helmut, Kupatt, Christian, Gerlach, Eckehart, Zahler, Stefan, Becker, Bernhard F., C Kupatt   +7 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Analysis of ACE Inhibitory Activity in Different Parts of Sea Cucumber (Apostichopus japonicus) and Optimization of Preparation Process of Active Peptides

Shipin gongye ke-ji
In this paper, the active parts of sea cucumber (Apostichopus japonicus) with high antihypertensive activity were screened and the preparation process of active peptides was optimized. Different parts (body wall, intestine, and ovum) of A. japonicus were
Yangduo WANG, Yongchang SU, Xiaoyan WANG, Wenzheng SHI, Zhiyu LIU   +4 more
doaj   +1 more source

Association between genetically proxied ACE inhibition and colorectal cancer risk in iterative leave-one-out analysis.

, 2022
Footnote: OR represents the exponential change in odds of cancer per genetically proxied inhibition of ACE equivalent to a 1 mmHg decrease in SBP. ACE, angiotensin-converting enzyme; OR, odds ratio; SBP, systolic blood pressure; SNP, single-nucleotide ...
Andrea Gsur (9900039), Mark Jenkins (425272), Jennifer Sjaarda (11856968), Mireia Obón-Santacana (11659724), Emma E. Vincent (7639052), Christopher I. Amos (7730234), James Yarmolinsky (739630), Steven Gallinger (108153), Demetrius Albanes (23581), Virginia Díez-Obrero (12041805), Guillaume Paré (84081), Rish K. Pai (12041811), Wei Zheng (25452), Marie Pigeyre (3165678), Jochen Hampe (77512), Tom G. Richardson (7779047), Victor Moreno (748751), George Davey Smith (7180727), Richard M. Martin (7180730), Vanessa Y. Tan (7756985), Heather Hampel (164499), Graham Casey (62350), Venexia M. Walker (12041808)   +22 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Inhibition of angiotensin converting enzyme (ACE) in plasma and tissue

, 1990
Inhibition of angiotensin-converting enzyme (ACE) in rat plasma and tissue was studied after administration of quinapril, a new orally active ACE inhibitor with an intermediate duration of action.
JOHNSTON CI, CHEN BZ, FABRIS, BRUNO, PUPIC V, PERICH R, Bruno Fabris, Bingzhong Chen, Colin I. Johnston, Vicki Pupic, Rose Perich   +9 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source