Results 61 to 70 of about 1,055,937 (242)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A novel ACE inhibitory peptide from Gadus morhua skin: Isolation, characterization and antihypertensive mechanisms

Journal of Functional Foods
This study aimed to develop a novel ACE inhibitory peptide from cod skin with antihypertensive activity. Cod skin collagen hydrolysate was prepared by stepwise enzymatic hydrolysis using Collagen hydrolase followed by flavourzyme.
Shuai Li, Jie Huai, Bingfu Yang, Cunxi Lu, Junjie Qiu, Yi Ding, Renjie Zhou, Shan Wang   +7 more
doaj   +1 more source

Identification of angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of pork loin

International Journal of Food Properties, 2019
This study aimed to identify angiotensin I-converting enzyme (ACE) inhibitory peptides in enzymatic hydrolysates from pork loin. Pork hydrolysates were produced by injecting different enzymes to the loins as follows: un-injected pork (fresh pork ...
Juhui Choe, Kuk-Hwan Seol, Dong-In Son, Hyun Jung Lee, Mooha Lee, Cheorun Jo   +5 more
doaj   +1 more source

Data_Sheet_1_Release of an encrypted, highly potent ACE-inhibitory peptide by enzymatic hydrolysis of moth bean (Vigna aconitifolia) protein.docx

, 2023
AimDietary approaches for the regulation of blood pressure are the need of the hour. Hence, identifying the foods possessing such activity is gaining importance.
Nancy Goyal (16241297), Sachin N. Hajare (16241300), Satyendra Gautam (558264)   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

A Length-Aware C-Terminal Rule for Prioritizing Short ACE-Inhibitory Peptides from Food Protein Hydrolysates. [PDF]

Foods
The discovery of angiotensin-converting enzyme (ACE)-inhibitory peptides from food protein hydrolysates is commonly guided by empirical fractionation or sequence-based prediction, but few screening rules have been evaluated at the hydrolysate level and ...
Li ML, Lai YJ, Wu PY, Li JC, Huang SM, Hsu KC.   +5 more
europepmc   +2 more sources

Egg-derived bioactive peptides with ACE-inhibitory properties : a literature update

, 2017
Egg proteins contain a wide set of peptide sequences which have an impact on cardiovascular health. Their modes-of-action involve{,} among others{,} the inhibition of angiotensin-converting enzyme (ACE) and antioxidant and anti-inflammatory properties ...
Grootaert, Charlotte, Sam Possemiers, Van Camp, John, Voorspoels, Stefan, Bea Matthijs, Charlotte Grootaert, Guy Smagghe, John Van Camp, Smagghe, Guy, Matthijs, Bea, Possemiers, Sam, Stefan Voorspoels   +11 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Jack Bean (Canavalia ensiformis) Tempeh: ACE-Inhibitory Peptide Formation during Absorption in the Small Intestine

, 2023
Research background. High blood pressure is the most significant cause of mortality globally. Some fermented foods include ACE-inhibitory peptides that help fight this dis-ease.
Indrati, Retno, Cahyanto, Muhammad Nur, Puspitojati, Endah, Marsono, Yustinus   +3 more
core   +1 more source