ADULT IMMUNIZATION WITH ACELLULAR PERTUSSIS VACCINE
The Pediatric Infectious Disease Journal, 1993 Objective. —To evaluate the safety and immunogenicity in adults of several different concentrations of an acellular pertussis vaccine. Design. —Double-blind, randomized, placebo-controlled trial. Setting. —Medical center immunization clinic. Participants. —One hundred eighteen healthy adult volunteers. Interventions.
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Human Vaccines & Immunotherapeutics, 2019 Pertussis is resurgent worldwide. Currently available acellular pertussis vaccines contain chemically detoxified pertussis toxin (PTc); a highly immunogenic genetically detoxified pertussis toxin (PTg) vaccine has been off the market for over a decade ...
Naveen Surendran, Michael Pichichero
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Specific Lung Mucosal and Systemic Immune-Responses After Oral Immunization of Mice with Salmonella-Typhimurium-Aroa, Salmonella-Typhi Ty21a, and Invasive Escherichia-Coli Expressing Recombinant Pertussis Toxin S1 Subunit [PDF]
, 1992 Pertussis toxin (PT) is considered an essential protective component for incorporation into new generation vaccines against Bordetella pertussis, the causative agent of whooping cough.
Guzman, Carlos A. +3 more
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After publication of certain vaccine recommendations made by the Advisory Committee on Immunization Practices, several unexpected events have occurred during implementation of these recommendations.
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Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization. [PDF]
Front Immunol, 2023 Yount KS +11 more
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Safety and Immunogenicity of a Respiratory Syncytial Virus Prefusion F Vaccine When Coadministered With a Tetanus, Diphtheria, and Acellular Pertussis Vaccine. [PDF]
J Infect Dis, 2022 Peterson JT +12 more
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Estimating Population-Level Effects of the Acellular Pertussis Vaccine Using Routinely Collected Immunization Data. [PDF]
Clin Infect Dis, 2021 Rane MS, Halloran ME.
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BACKGROUNDAcellular pertussis vaccines replaced whole-cell vaccines for the 5-dose childhood vaccination series in 1997. A sixth dose of pertussis-containing vaccine, tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis, adsorbed (Tdap ...
core
Impact of vaccination on epidemiology of diphtheria and pertussis
Vaccine Research, 2015 Whooping cough and diphtheria are vaccine preventable diseases. Diphtheria, due to Corynebacterium diphtheriae or Corynebactium ulcerans, two Gram positive bacteria, is a serious upper respiratory tract disease with high morbidity and mortality rates ...
N Guiso
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