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Quantifying the impact of vaccination on pertussis dynamics in Sweden. [PDF]
Brett TS +6 more
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Effects of maternal exposure to an adsorbed acellular diphtheria-tetanus-pertussis (reduced-dose) combined vaccine on prenatal and postnatal development in Sprague-Dawley rats: a preclinical study. [PDF]
Kong W +23 more
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Pediatric Clinics of North America, 2000
Although whole-cell pertussis vaccines have been highly effective in preventing whooping cough, their common and burdensome adverse reactions have spurred the development of safer alternatives. Seven acellular vaccines are licensed in one or more countries; four have been licensed thus far in the United States, and more may follow.
M D, Decker, K M, Edwards
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Although whole-cell pertussis vaccines have been highly effective in preventing whooping cough, their common and burdensome adverse reactions have spurred the development of safer alternatives. Seven acellular vaccines are licensed in one or more countries; four have been licensed thus far in the United States, and more may follow.
M D, Decker, K M, Edwards
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Pertussis vaccine controversies and acellular pertussis vaccine
The Indian Journal of Pediatrics, 2003Pertussis still continues to cause significant morbidity and mortality worldwide. Because of the high reactogenicity of whole cell pertussis vaccine, it had evoked public controversy in several countries. In 1970 Japan abandoned use of whole cell pertussis vaccine and mounted efforts to develop better vaccine.
Raju C, Shah, Anuj R, Shah
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ACELLULAR PERTUSSIS VACCINES IN ADULTS
Infectious Disease Clinics of North America, 1999The pathogenesis of pertussis, and the epidemiology and clinical manifestations of pertussis after childhood are reviewed as a background for a discussion of recent clinical trials of acellular pertussis vaccines in adults, and the vaccines' potential for routine use in adolescents and adults.
W A, Keitel, K M, Edwards
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Acellular pertussis vaccines in China
Vaccine, 2012In China, whole-cell pertussis (Pw) vaccines were produced in the early 1960s and acellular pertussis (Pa) vaccines were introduced in 1995. Pa vaccines have now almost completely replaced Pw vaccines in the national immunization program. To strengthen the regulation of vaccines used in China, a vaccine lot release system was established in 2001 and Pa
Lichan, Wang +2 more
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Acellular Pertussis Vaccines for Infants
New England Journal of Medicine, 1996Whole-cell vaccines, which are suspensions of killed Bordetella pertussis organisms, are among our most effective and least satisfactory vaccines.
K M, Edwards, M D, Decker
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Development of Acellular Pertussis Vaccines
Biologicals, 1999In 1974, the authors reported the isolation and characterization of protective antigens of Bordetella pertussis in mice. With this information, an acellular pertussis vaccine was developed, composed mainly of pertussis toxin (PT) and filamentous haemagglutinin (FHA).
Y, Sato, H, Sato
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