Results 71 to 80 of about 101,023 (246)

Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease

Biomedicines, 2020
Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase.
Yanchao Jiang, Ting Zhang, Praveen Kusumanchi, Sen Han, Zhihong Yang, Suthat Liangpunsakul   +5 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

EMBO Molecular Medicine, 2017
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly ...
Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas   +20 more
doaj   +1 more source

Identification and characterization of dysregulated P-element induced wimpy testis-interacting RNAs in head and neck squamous cell carcinoma. [PDF]

, 2019
It is clear that alcohol consumption is a major risk factor in the pathogenesis of head and neck squamous cell carcinoma (HNSCC); however, the molecular mechanism underlying the pathogenesis of alcohol-associated HNSCC remains poorly understood.
Ku, Jonjei, Kuo, Selena Z, Li, Pin Xue, Ongkeko, Weg M, Saad, Maarouf A, Wang-Rodriguez, Jessica, Yu, Michael Andrew, Zheng, Hao   +7 more
core  

Ethanol triggers grape gene expression leading to anthocyanin accumulation during berry ripening [PDF]

, 2002
Recent studies have shown that low doses of ethanol stimulate the maturation of some fruits. The present work showed that spraying Cabernet Sauvignon grapes, with 5% ethanol at veraison enhances the anthocyanin accumulation.
Chervin, Christian, El-Kereamy, Ashraf, Ford, Christopher, Mondies, Hélène, Monje, Marie-Carmen, Moutounet, Michel, Nepveu, Françoise, Roustan, Jean-Paul, Souquet, Jean-Marc, Van Heeswijck, R.   +9 more
core   +4 more sources

Basal Plane Activation of SnS2 Thin‐Film by Fluorine Doping for Selective Solar‐Driven CO2 Reduction With Enhanced Quantum Efficiency

Advanced Science, EarlyView.
The synergistic effect of fluorine doping and sulfur vacancies boosts the activity of the active sites without active‐site modulation, leading to enhanced CO2 photoreduction efficiency and a selectivity switch from CH4 to CO on tin disulfide continuous thin films. ABSTRACT Photocatalytic conversion of CO2 into value‐added fuels offers a viable approach
Tadios Tesfaye Mamo, Mohammad Qorbani, Adane Gebresilassie Hailemariam, Putikam Raghunath, Che‐Men Chu, Wen‐Hsin Yuan, Amr Sabbah, Yen‐Yu Wang, Shuo‐Yun Chang, Ming‐Chang Lin, Wei‐Yen Woon, Yu‐Jung Lu, Heng‐Liang Wu, Ken‐Tsung Wong, Kuei‐Hsien Chen, Li‐Chyong Chen   +15 more
wiley   +1 more source

Impact of Condensed Tannin and Sulfur Dioxide Addition on Acetaldehyde Accumulation and Anthocyanin Profile of Vitis vinifera L. Cv. Cabernet Sauvignon Wines During Alcoholic Fermentation

Molecules
Acetaldehyde is a key carbonyl by-product during red wine alcoholic fermentation; it is reactive and takes part in certain reactions involving anthocyanin.
Qinglong Wang, Xiaoqian Cui, Jiaqi Wang, Heqiang Chang, Junzhe Wang, Ang Zhang, Yang Zhou, Zhiyong Xu, Lingmin Dai, Guomin Han   +9 more
doaj   +1 more source

Integrating Horizontal Gene Transfer and Common Descent to Depict Evolution and Contrast It with ‘‘Common Design [PDF]

, 2010
Horizontal gene transfer (HGT) and common descent interact in space and time. Because events of HGT co-occur with phylogenetic evolution, it is difficult to depict evolutionary patterns graphically. Tree-like representations of life’s diversification are
Espinosa, Avelina, Paz-y-Mino C., Guillermo   +1 more
core   +2 more sources

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Experimental and modeling study of the low-temperature oxidation of large alkanes [PDF]

, 2008
This paper presents an experimental and modeling study of the oxidation of large linear akanes (from C10) representative from diesel fuel from low to intermediate temperature (550-1100 K) including the negative temperature coefficient (NTC) zone.
Battin-Leclerc, Frédérique, Biet, Joffrey, Glaude, Pierre-Alexandre, Hakka, Mohammed Hichem, Warth, Valérie   +4 more
core   +3 more sources