Results 31 to 40 of about 258,848 (293)

Crystal structures of two (Z)-2-(4-oxo-1,3-thiazolidin-2-ylidene)acetamides

Acta Crystallographica Section E: Crystallographic Communications, 2017
The crystal structures of two (oxothiazolidin-2-ylidene)acetamides, namely (Z)-2-[2-(morpholin-4-yl)-2-oxoethylidene]thiazolidin-4-one, C9H12N2O3S, (I), and (Z)-N-(4-methoxyphenyl)-2-(4-oxothiazolidin-2-ylidene)acetamide, C12H12N2O3S, (II), are described
Aleksei Galushchinskiy, Pavel Slepukhin, Konstantin Obydennov   +2 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 2-azido-N-(4-fluorophenyl)acetamide

Acta Crystallographica Section E: Crystallographic Communications, 2022
The asymmetric unit of the title compound, C8H7FN4O, consists of two independent molecules differing in the orientation of the azido group. Each molecule forms N—H...O hydrogen-bonded chains along along the c-axis direction with its symmetry-related ...
Mohcine Missioui, Walid Guerrab, Abdulsalam Alsubari, Joel T. Mague, Youssef Ramli   +4 more
doaj   +1 more source

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]

, 2007
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi, Backvall, Bailey, Beer, Chen, Chretien, David J. Vocadlo, Davies, Davies, Dennis, Dong, Dorfmueller, Edward J. Taylor, Emsley, Esnouf, Fairweather, Gideon J. Davies, Horsch, Junge, Kappes, Keith A. Stubbs, Knapp, Kraulis, Legler, Lin, Liu, Liu, Macauley, Mark, Money, Murshudov, Namiki, Nicotra, Ogawa, Rana, Rao, Rebecca J. Dennis, Robert V. Stick, Salleh, Scaffidi, Shanmugasundaram, Shitara, Sigurskjold, Stubbs, Stubbs, Svensson, Tanaka, Terinek, Tews, Vocadlo   +49 more
core   +1 more source

N-(4-Sulfamoylphenyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C8H10N2O3S, the dihedral angle between the acetamide group and the benzene ring is 15.59 (12)° and the amino group is close to being perpendicular to the benzene ring [N—S—Car—Car(ar = aromatic) torsion angle = 109.4 (2)°]. In the crystal, molecules are linked into supramolecular tubes parallel to [001] by amine–amide N—H...O ...
Abdullah M. Asiri, Hassan M. Faidallah, Tariq R. Sobahi, Seik Weng Ng, Edward R. T. Tiekink   +4 more
openaire   +3 more sources

2-(4-Chlorophenyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C(8)H(8)ClNO, the acetamide group is twisted out the benzene plane with a dihedral angle of 83.08 (1)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, forming layers parallel to the ab plane.
Dong-Sheng Ma, Pei-Jiang Liu, Shuai Zhang, Guang-Feng Hou   +3 more
openaire   +3 more sources

Practical guidance for the implementation of the CRISPR genome editing tool in filamentous fungi [PDF]

, 2019
Background: Within the last years, numerous reports described successful application of the CRISPR nucleases Cas9 and Cpf1 for genome editing in filamentous fungi.
Haefner, Stefan, Kwon, Jin, Meyer, Vera, Schütze, Tabea, Spohner, Sebastian   +4 more
core   +1 more source

2-(4-Iodophenoxy)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
The mol-ecule of the title compound, C(8)H(8)INO(2), amide-typical resonance shortens the nominal C-N single bond to 1.322 (7) Å. In the crystal, hydrogen bonds involving both nitro-gen-bound H atoms as well as C-H⋯O contacts connect the mol-ecules into double layers approximately perpendicular to the crystallographic b axis.
Richard Betz, Cedric McCleland, Stephen Glover   +2 more
openaire   +3 more sources

Crystal structure of N-[4-amino-5-cyano-6-(methylsulfanyl)pyridin-2-yl]acetamide hemihydrate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C9H10N4OS·0.5H2O, crystallizes with two independent molecules (A and B) in the asymmetric unit, together with a water molecule of crystallization.
Mehmet Akkurt, Kyle S. Knight, Shaaban K. Mohamed, Bahgat R. M. Hussein, Mustafa R. Albayati   +4 more
doaj   +1 more source

Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line

Pharmaceuticals, 2020
Dual targeting of epidermal growth factor receptor (EGFR) and human EGFR-related receptor 2 (HER2) is a proven approach for the treatment of lung cancer. With the aim of discovering effective dual EGFR/HER2 inhibitors targeting non-small cell lung cancer
Ranza Elrayess, Yasmine M. Abdel Aziz, Mohamed Saleh Elgawish, Marwa Elewa, Asmaa S. A. Yassen, Sameh S. Elhady, Hosam A. Elshihawy, Mohamed M. Said   +7 more
doaj   +1 more source

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy [PDF]

, 2014
Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer.
Allinson, Ashworth, Ashworth, Bertram, Bosenberg, Botti, Bristow, Burma, Campisi, Curtin, Eng, Eng, Foiani, Gerson, He, Helleday, Hickson, Kelley, Larue, Li, Madhusudan, Madhusudan, Madhusudan, Madhusudan, Maloney, Maloney, Meyskens, Newton-Bishop, Pandolfi, Pandolfi, Parsons, Polyak, Pu, Reis-Filho, Reis-Filho, Ribas, Rimm, Robertson, Rocha, Simeonov, Simeonov, Smalley, Stambolic, Stambolic, Teo, Wadhwa, Wilson, Wilson, Yin, Zhang   +49 more
core   +2 more sources