Results 1 to 10 of about 3,911 (190)

Novel Chalcone Derivatives as Anti-Leishmania infantum Agents with Potential Synergistic Activity and In Silico Insights [PDF]

Antibiotics
Background: Visceral leishmaniasis (VL) is a neglected tropical disease with limited therapeutic options, often restricted by toxicity, high costs, and resistance. Chalcones are promising scaffolds for the development of antiparasitic agents. Objectives:
Ana Letícia Monteiro Fernandes, Abraão Pinheiro Sousa, Delva Thyares Fonseca Lamec, Leonardo Lima Cardoso, Rosália Santos Ferreira, Shayenne Eduarda Ramos Vanderley, Petrônio Filgueiras Athayde-Filho, Gabriela Fehn Fiss, Tatjana Souza Lima Keesen   +8 more
doaj   +2 more sources

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides [PDF]

Beilstein Journal of Organic Chemistry
The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation.
Ayesha Saeed, Shahana Ehsan, Muhammad Zia-ur-Rehman, Erin M. Marshall, Sandra Loesgen, Abdus Saleem, Simone Giovannuzzi, Claudiu T. Supuran   +7 more
doaj   +2 more sources

Synthesis and antitumor activity of 1,3,4-oxadiazole substituted 2-(5-ylidene-2,4-dioxothiazolidin-3-yl)-acetamides [PDF]

Pharmacia, 2023
A series of novel 1,3,4-oxadiazole substituted 2-(5-aryl/heterylidene-2,4-dioxothiazolidine-3-ylidene)-acetamides and their 5-unsubstituted analogues have been synthesized following N-alkylation reaction of 2-chloro-N-(5-aryl-[1,3,4]oxadiazol-2-yl ...
Maryan Lelyukh, Myroslava Kalytovska, Marta Zastryzhna, Arkadii Savchenko, Ihor Chaban, Stefan Harkov   +5 more
doaj   +3 more sources

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line

Pharmaceuticals, 2023
Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (1 ...
Naheed Akhter, Sidra Batool, Samreen Gul Khan, Nasir Rasool, Fozia Anjum, Azhar Rasul, Şevki Adem, Sadaf Mahmood, Aziz ur Rehman, Mehr un Nisa, Zainib Razzaq, Jørn B. Christensen, Mohammed A. S. Abourehab, Syed Adnan Ali Shah, Syahrul Imran   +14 more
doaj   +1 more source

Ultrasound Assisted Synthesis and In Silico Modelling of 1,2,4-Triazole Coupled Acetamide Derivatives of 2-(4-Isobutyl phenyl)propanoic acid as Potential Anticancer Agents

Molecules, 2022
The development of an economical method for the synthesis of biologically active compounds was the major goal of this research. In the present study, we have reported the ultrasound-radiation-assisted synthesis of a series of novel N-substituted 1,2,4 ...
Sadaf Mahmood, Samreen Gul Khan, Azhar Rasul, Jørn Bolstad Christensen, Mohammed A. S. Abourehab   +4 more
doaj   +1 more source

From amines to (form)amides: a simple and successful mechanochemical approach

Beilstein Journal of Organic Chemistry, 2022
Two easily accessible routes for preparing an array of formylated and acetylated amines under mechanochemical conditions are presented. The two methodologies exhibit complementary features as they enable the derivatization of aliphatic and aromatic ...
Federico Casti, Rita Mocci, Andrea Porcheddu   +2 more
doaj   +1 more source

Synthesis and antioxidant activity of six novel N-ferrocenylmethyl-N-(nitrophenyl)- and -N-(cyanophenyl)-acetamides: Cyclic voltammetry and molecular docking studies

Journal of Electrochemical Science and Engineering, 2022
Cyclic voltammetry (CV) assays were performed to measure superoxide anion radical (O–2-) scavenging activities of six novel N-ferrocenylmethyl-N-(nitrophenyl)-acetamides and N-fer­rocenylmethyl-N-(cyanophenyl)acetamides (FMA1-FMA6), followed by molecular
Abdellatif Kedadra, Touhami Lanez, Elhafnaoui Lanez, Hadia Hemmami, Meriem Henni   +4 more
doaj   +1 more source

N-acetylation of 2-aminobenzothiazoles with Acetic Acid for Evaluation of Antifungal Activity and In Silico Analysis

Journal of Molecular Docking, 2021
Acetamides (S30A1 and S30) were synthesized from benzo[d]thiazol-2-amine and 6-nitrobenzo[d]thiazol-2-amine by direct use of acetic acid instead of acetylating agents.
Sukumar Bepary, Bishyajit Kumar Biswas, Prosenjit Ghosh, Md. Aminul Haque, Tran Quang De   +4 more
doaj   +1 more source

N-(9,10-Dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) Acetamides: Synthesis, Antioxidant and Antiplatelet Activity

Acta Chimica Slovenica, 2022
The synthesis of new N-(9,10-dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) acetamides was carried out using reaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracene-1(2)-yl)acetamides with functionalized thiols in the presence of potassium carbonate ...
Maryna Stasevych, Viktor Zvarych, Olena Yaremkevych, Mykhaylo Vovk, Alla Vaskevych, Tetiana Halenova, Olexii Savchuk   +6 more
doaj   +1 more source

N-(Phenylsulfonyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(8)H(9)NO(3)S, the N-H bond is in an anti-periplanar conformation with respect to the C=O bond. The crystal packing is stabilized by N-H⋯O hydrogen bonds, generating C(4) chains propagating in [001].
B. Thimme Gowda, Sabine Foro, P. G. Nirmala, Hartmut Fuess   +3 more
openaire   +3 more sources