Results 1 to 10 of about 21,852 (266)

Synthesis and Evaluation of N-(3-Trifluoroacetyl-indol-7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties [PDF]

Molecules, 2017
A series of novel N-((2,5-diaryl-3-trifluoroacetyl)-1H-indol-7-yl)acetamides has been prepared via a successive and one-pot reaction sequence involving initial trifluoroacetic acid-mediated Beckmann rearrangement of the oximes derived from the 1-(2,5 ...
Malose J. Mphahlele, Mmakwena M. Mmonwa, Yee Siew Choong   +2 more
doaj   +7 more sources

Synthetic approaches to multifunctional indenes [PDF]

Beilstein Journal of Organic Chemistry, 2011
The synthesis of multifunctional indenes with at least two different functional groups has not yet been extensively explored. Among the plausible synthetic routes to 3,5-disubstituted indenes bearing two different functional groups, such as the [3 ...
Neus Mesquida, Sara López-Pérez, Immaculada Dinarès, Ermitas Alcalde   +3 more
doaj   +2 more sources

Novel Chalcone Derivatives as Anti-Leishmania infantum Agents with Potential Synergistic Activity and In Silico Insights [PDF]

Antibiotics
Background: Visceral leishmaniasis (VL) is a neglected tropical disease with limited therapeutic options, often restricted by toxicity, high costs, and resistance. Chalcones are promising scaffolds for the development of antiparasitic agents. Objectives:
Ana Letícia Monteiro Fernandes, Abraão Pinheiro Sousa, Delva Thyares Fonseca Lamec, Leonardo Lima Cardoso, Rosália Santos Ferreira, Shayenne Eduarda Ramos Vanderley, Petrônio Filgueiras Athayde-Filho, Gabriela Fehn Fiss, Tatjana Souza Lima Keesen   +8 more
doaj   +2 more sources

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides [PDF]

Beilstein Journal of Organic Chemistry
The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation.
Ayesha Saeed, Shahana Ehsan, Muhammad Zia-ur-Rehman, Erin M. Marshall, Sandra Loesgen, Abdus Saleem, Simone Giovannuzzi, Claudiu T. Supuran   +7 more
doaj   +2 more sources

Crystal structures of two C,N-disubstituted acetamides: 2-(4-chlorophenyl)-N-(2-iodophenyl)acetamide and 2-(4-chlorophenyl)-N-(pyrazin-2-yl)acetamide [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the crystal of 2-(4-chlorophenyl)-N-(2-iodophenyl)acetamide, C14H11ClINO, molecules are linked by a combination of N—H...O and C—H...O hydrogen bonds to form a C(4)C(4)[R21(7)] chain of rings and chains of this type are linked by a combination of C—Cl.
Badiadka Narayana, Hemmige S. Yathirajan, Ravindranath Rathore, Christopher Glidewell   +3 more
doaj   +8 more sources

Synthesis and antitumor activity of 1,3,4-oxadiazole substituted 2-(5-ylidene-2,4-dioxothiazolidin-3-yl)-acetamides [PDF]

Pharmacia, 2023
A series of novel 1,3,4-oxadiazole substituted 2-(5-aryl/heterylidene-2,4-dioxothiazolidine-3-ylidene)-acetamides and their 5-unsubstituted analogues have been synthesized following N-alkylation reaction of 2-chloro-N-(5-aryl-[1,3,4]oxadiazol-2-yl ...
Maryan Lelyukh, Myroslava Kalytovska, Marta Zastryzhna, Arkadii Savchenko, Ihor Chaban, Stefan Harkov   +5 more
doaj   +3 more sources

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line

Pharmaceuticals, 2023
Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (1 ...
Naheed Akhter, Sidra Batool, Samreen Gul Khan, Nasir Rasool, Fozia Anjum, Azhar Rasul, Şevki Adem, Sadaf Mahmood, Aziz ur Rehman, Mehr un Nisa, Zainib Razzaq, Jørn B. Christensen, Mohammed A. S. Abourehab, Syed Adnan Ali Shah, Syahrul Imran   +14 more
doaj   +1 more source

Ultrasound Assisted Synthesis and In Silico Modelling of 1,2,4-Triazole Coupled Acetamide Derivatives of 2-(4-Isobutyl phenyl)propanoic acid as Potential Anticancer Agents

Molecules, 2022
The development of an economical method for the synthesis of biologically active compounds was the major goal of this research. In the present study, we have reported the ultrasound-radiation-assisted synthesis of a series of novel N-substituted 1,2,4 ...
Sadaf Mahmood, Samreen Gul Khan, Azhar Rasul, Jørn Bolstad Christensen, Mohammed A. S. Abourehab   +4 more
doaj   +1 more source

From amines to (form)amides: a simple and successful mechanochemical approach

Beilstein Journal of Organic Chemistry, 2022
Two easily accessible routes for preparing an array of formylated and acetylated amines under mechanochemical conditions are presented. The two methodologies exhibit complementary features as they enable the derivatization of aliphatic and aromatic ...
Federico Casti, Rita Mocci, Andrea Porcheddu   +2 more
doaj   +1 more source

Synthesis and antioxidant activity of six novel N-ferrocenylmethyl-N-(nitrophenyl)- and -N-(cyanophenyl)-acetamides: Cyclic voltammetry and molecular docking studies

Journal of Electrochemical Science and Engineering, 2022
Cyclic voltammetry (CV) assays were performed to measure superoxide anion radical (O–2-) scavenging activities of six novel N-ferrocenylmethyl-N-(nitrophenyl)-acetamides and N-fer­rocenylmethyl-N-(cyanophenyl)acetamides (FMA1-FMA6), followed by molecular
Abdellatif Kedadra, Touhami Lanez, Elhafnaoui Lanez, Hadia Hemmami, Meriem Henni   +4 more
doaj   +1 more source