Results 11 to 20 of about 21,852 (266)

Computational and theoretical chemistry of newly synthesized and characterized 2,2’-(5,5’-(1,4-phenylene)bis(1H-tetrazole-5,1-diyl))bis-N-acetamides

BMC Chemistry, 2023
Energetic heterocycles, including pyridines, triazoles, and tetrazoles, exhibit greater density, heats of formation, and oxygen balance compared to their carbocyclic counterparts, making them a promising approach for synthesizing novel bis-tetrazole ...
Syeda Abida Ejaz, Aftab Farid, Seema Zargar, Pervaiz Ali Channar, Mubashir Aziz, Tanveer A. Wani, Hafiz Muhammad Attaullah, Rabail Ujhan, Arfa Tehzeeb, Aamer Saeed, Hafiz Saqib Ali, Mauricio F. Erben   +11 more
doaj   +2 more sources

New thioxothiazolidinyl-acetamides derivatives as potent urease inhibitors: design, synthesis, in vitro inhibition, and molecular dynamic simulation

Scientific Reports, 2023
To identify potent urease inhibitors, in the current study, a series of thioxothiazolidinyl-acetamides were designed and synthesized. The prepared compounds were characterized by spectroscopic techniques, including FTIR, 1HNMR, 13CNMR, and elemental ...
Navid Dastyafteh, Milad Noori, Mohammad Nazari Montazer, Kamiar Zomorodian, Somayeh Yazdanpanah, Aida Iraji, Minoo Khalili Ghomi, Shahrzad Javanshir, Mehdi Asadi, Mehdi Dianatpour, Mahmood Biglar, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi   +13 more
doaj   +2 more sources

Bis-pyrimidine acetamides: design, synthesis and biological evaluation

Chemistry Central Journal, 2017
Background In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents.
Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah, Balasubramanian Narasimhan   +5 more
doaj   +2 more sources

Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry

Journal of the American Chemical Society, 2023
Electrophiles for covalent inhibitors that are suitable for in vivo administration are rare. While acrylamides are prevalent in FDA-approved covalent drugs, chloroacetamides are considered too reactive for such purposes.
Rambabu N. Reddi, A. Rogel, R. Gabizon, D. G. Rawale, B. Harish, Shir Marom, Barr Tivon, Yamit Shorer Arbel, Neta Gurwicz, R. Oren, K. David, Jingjing Liu, Shirly Duberstein, M. Itkin, S. Malitsky, H. Barr, B. Katz, Y. Herishanu, I. Shachar, Ziv Shulman, N. London   +20 more
semanticscholar   +1 more source

Photochemical C-F Activation Enables Defluorinative Alkylation of Trifluoroacetates and -Acetamides.

Journal of the American Chemical Society, 2021
The installation of gem-difluoromethylene groups into organic structures remains a daunting synthetic challenge despite their attractive structural, physical, and biochemical properties.
Mark W Campbell, Viktor C Polites, Shivani Patel, Juliette E Lipson, Jadab Majhi, G. Molander   +5 more
semanticscholar   +1 more source

Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.

ACS Medicinal Chemistry Letters, 2022
Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a novel series of 2-(quinoline-4-yloxy)acetamides was synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Structure-activity
Ana Flávia Borsoi, Laura Manzoli Alice, N. Sperotto, A. S. Ramos, B. L. Abbadi, Fernanda Souza Macchi Hopf, Adilio da Silva Dadda, R. S. Rambo, Rodrigo Braccini Madeira Silva, J. D. Paz, K. Pissinate, M. N. Muniz, C. Neves, L. Galina, L. C. González, M. Perelló, Alexia de Matos Czeczot, Mariana Leyser, Sílvia Dias de Oliveira, Graziela de Araújo Lock, Bibiana Verlindo de Araújo, T. D. Costa, C. V. Bizarro, L. A. Basso, Pablo Machado   +24 more
semanticscholar   +1 more source

Indole-3-acetamides: As Potential Antihyperglycemic and Antioxidant Agents; Synthesis, In Vitro α-Amylase Inhibitory Activity, Structure–Activity Relationship, and In Silico Studies

ACS Omega, 2021
Indole-3-acetamides (1–24) were synthesized via coupling of indole-3-acetic acid with various substituted anilines in the presence of coupling reagent 1,1-carbonyldiimidazole.
Kanwal, K. Khan, Sridevi Chigurupati, Farman Ali, Munissa Younus, Maha Aldubayan, A. Wadood, Huma Khan, M. Taha, S. Perveen   +9 more
semanticscholar   +1 more source

Access to Isoquinolin-2(1H)-yl-acetamides and Isoindolin-2-yl-acetamides from a Common MCR Precursor

Journal of Organic Chemistry, 2022
We achieved a divergent synthesis of isoquinolin-2(1H)-yl-acetamides (16 examples, up to 90% yields) and regioselective isoindolin-2-yl-acetamides (14 examples, up to 93% yields) in moderate to good yields by reacting various substituted ethanones or ...
Xin Li, Q. Wang, Q. Zheng, K. Kurpiewska, J. Kalinowska‐Tłuścik, A. Dömling   +5 more
semanticscholar   +1 more source

Design, Synthesis and Biological Evaluation of Novel Thienylpyridyl- and Thioether-Containing Acetamides and Their Derivatives as Pesticidal Agents

Molecules, 2021
Referring to the structural information of the “hit” compound A from the reported pharmacophore-based virtual screening, a series of novel thienylpyridyl- and thioether/sulfoxide/sulfone-containing acetamide derivatives have been designed and synthesized.
Huangong Li, Na Yang, Li-xia Xiong, Baolei Wang   +3 more
semanticscholar   +1 more source

N-acetylation of 2-aminobenzothiazoles with Acetic Acid for Evaluation of Antifungal Activity and In Silico Analysis

Journal of Molecular Docking, 2021
Acetamides (S30A1 and S30) were synthesized from benzo[d]thiazol-2-amine and 6-nitrobenzo[d]thiazol-2-amine by direct use of acetic acid instead of acetylating agents.
Sukumar Bepary, Bishyajit Kumar Biswas, Prosenjit Ghosh, Md. Aminul Haque, Tran Quang De   +4 more
doaj   +1 more source