Results 41 to 50 of about 21,852 (266)

Radical condensation between benzylic alcohols and acetamides to form 3-arylpropanamides†

Chemical Science, 2020
A new radical condensation reaction is developed where benzylic alcohols and acetamides are coupled to generate 3-arylpropanamides with water as the only byproduct.
Kobra Azizi, R. Madsen
semanticscholar   +1 more source

The search for the 'next' euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning [PDF]

, 2019
Purpose: A detailed review on the chemistry and pharmacology of non-fentanil novel synthetic opioid receptor agonists, particularly N-substituted benzamides and acetamides (known colloquially as U-drugs) and 4-aminocyclohexanols, developed at the Upjohn ...
A Helander, A Regina La, A Schneir, AG Hayes, AG Hayes, AJ Krotulski, AJ Krotulski, ALA Mohr, C McKenzie, C Soussan, Craig McKenzie, D Fabregat-Safont, D Lednicer, D Lednicer, D Lednicer, D Lednicer, D Lednicer, D Papsun, E Gerace, GW Peng, I Metushi, IM McIntyre, J Seither, J Szmuszkovicz, J Szmuszkovicz, JB Zawilska, JK O’Donnell, K Domanski, K Koch, KA Rambaran, Kirti Kumari Sharma, KN Ellefsen, KT Vo, L Ventura, M Dziadosz, M Katselou, MC Hout Van, MH Baumann, MJ Jones, MP Prekupec, Niamh NicDaeid, NJ Harper, P Armenian, P Armenian, P Nikolaou, PF Voigtlander Von, PF Voigtlander Von, PF Voigtlander Von, RA Fujimoto, RA Lahti, RT Brittain, SA Harding, SC Ifeagwu, SP Elliott, Tim G. Hales, TP Rohrig, USAN Council, V Coopman, Vaidya Jayathirtha Rao, W Fleming, X Ruan, Z Davey, Z Li, ZH Liu   +63 more
core   +2 more sources

N-(2,3-Dimethylphenyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
The conformation of the N-H bond in the structure of the title compound, C(10)H(13)NO, is syn to both the 2- and 3-methyl substituents on the aromatic ring, and is anti to the C=O bond. N-H⋯O hydrogen bonds link the mol-ecules into supra-molecular chains.
Hartmut Fuess, Hiromitsu Terao, Sabine Foro, B. Thimme Gowda   +3 more
openaire   +3 more sources

Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: Novel CDK5 probes [PDF]

, 2016
Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the ...
Alkorta, Ibon, Fueyo-González, Francisco, González-Vera, Juan A., Herranz, Rosario, Morris, May C., Peyressatre, Marion   +5 more
core   +2 more sources

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.

ACS Medicinal Chemistry Letters, 2019
KRAS regulates many cellular processes including proliferation, survival, and differentiation. Point mutants of KRAS have long been known to be molecular drivers of cancer.
Y. Shin, Joon Won Jeong, Ryan P Wurz, Pragathi Achanta, T. Arvedson, M. Bartberger, Iain D G Campuzano, R. Fucini, Stig K. Hansen, J. Ingersoll, Jeffrey S. Iwig, J. Lipford, V. Ma, D. J. Kopecky, J. McCarter, Tisha San Miguel, C. Mohr, S. Sabet, A. Y. Saiki, Andrew M. Sawayama, Steven G. Sethofer, C. Tegley, Laurie P. Volak, Kevin C Yang, B. Lanman, D. Erlanson, V. Cee   +26 more
semanticscholar   +1 more source

N-(4-Hydroxyphenethyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
In the title compound, C(10)H(13)NO(2), the occurrence of inter-molecular N-H⋯O and O-H⋯O hydrogen bonds between the hydr-oxy and acetamido groups results in the formation of tetra-mers with an R(4) (4)(25) graph-set motif. These tetra-mers are further assembled, building up a corrugated sheet parallel to (001).
Bo Wang, Yun Chai, Peizhen Tao, Mingliang Liu   +3 more
openaire   +3 more sources

Novel synthetic routes to thienocarbazoles via palladium or copper catalyzed amination or amidation of arylhalides and intramolecular cyclization [PDF]

, 2002
Palladium or copper catalyzed aminations or amidations were performed to obtain diarylamines and diarylacetamides precursors of thienocarbazoles. The fact that an ortho-bromodiarylamine didn’t cyclize to the corresponding thienocarbazole under conditions
Cagniant, Cagniant, Chakraborty, Dalton, Dougherty, Ferreira, Freeman, Gilbert Kirsch, Ihmels, Isabel C.F.R Ferreira, Iwaki, Knölker, Knölker, Maria-João R.P Queiroz, Ostrovidov, Patani, Peixoto, Pierre, Pierre, Rosseau-Richard, Thornerm, Wolfe   +21 more
core   +2 more sources

Isoeugenol and Hybrid Acetamides against Candida albicans Isolated from the Oral Cavity

Pharmaceuticals, 2020
Isougenol is a phytoconstituent found in several essential oils. Since many natural products are potent antimicrobials, the synthesis of hybrid molecules—combining the chemical skeleton of the phytochemical with synthetic groups—can generate substances ...
D. Medeiros, J. Oliveira-Júnior, J. Nóbrega, L. Cordeiro, J. Jardim, H. Souza, Gracielle Silva, P. Athayde-Filho, J. Barbosa-Filho, L. Scotti, E. Lima   +10 more
semanticscholar   +1 more source

N-(3,4-Dimethylphenyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2007
The conformation of the N-H bond in the title compound (34DMPA), C(10)H(13)NO, is syn to the 3-methyl substituent in the aromatic ring, in contrast to the anti conformation observed with respect to the 3-chloro substituent in N-(3,4-dichloro-phen-yl)acetamide (34DCPA). The asymmetric unit of the structure contains three mol-ecules.
B. Thimme Gowda, Sabine Foro, Hartmut Fuess   +2 more
openaire   +3 more sources

Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressor [PDF]

, 2009
Exposure to chronic restraint (CR) modifies the hypothalamic–pituitary–adrenal (HPA) axis response to subsequent acute stressors with adaptation of the response to a homotypic and sensitization of the response to a heterotypic stressor. Since vasopressin
Craighead, Mark, Harrison, Louise R., Lightman, Stafford L., MacSweeney, Cliona P., Spiga, Francesca, Thomson, Fiona J.   +5 more
core   +1 more source