Results 51 to 60 of about 127,361 (186)

Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

EBioMedicine, 2018
Background: Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of action, and concern about the possibility of adverse effects on reproductive health.
Isaac V. Cohen, Elizabeth T. Cirulli, Matthew W. Mitchell, Thomas J. Jonsson, James Yu, Naisha Shah, Tim D. Spector, Lining Guo, J. Craig Venter, Amalio Telenti   +9 more
doaj   +1 more source

Postoperative pain management in children: Guidance from the pain committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) [PDF]

, 2018
The main remit of the European Society for Paediatric Anaesthesiology (ESPA) Pain Committee is to improve the quality of pain management in children. The ESPA Pain Management Ladder is a clinical practice advisory based upon expert consensus to help to ...
Adamek, Akin, Al-Zaben, Alm, Amminnikutty, Amoli, Anderson, Anderson, Antila, Arcioni, Association of Paediatric Anaesthetists of Great Britain and Ireland, Aubrun, Aveline, Aysenur, Bailey, Bailie, Bakan, Baley, Becke, Beers, Bell, Ben-Meir, Bertini, Bhalla, Birmingham, Bouwmeester, Bozkurt, Breitfeld, Breschan, Breschan, Brown, Brown, Büttner, Carstensen, Cha, Chan, Chou, Conti, Cousins, Crellin, Cyna, Dadure, Dadure, Dahi-Taleghani, Dahmani, Dalens, Das, Derry, Derry, Duedahl, Ecoffey, El-Fattah, Elshammaa, Fendrich, Fieler, Finkel, Flack, Fösel, Ganidagli, Gear, Gemma, Ginsberg, Glover, Habre, He, Hicks, Hinz, Holmer Pettersson, Hong, Howard, Hudcova, Huenseler, Huynh, Höhne, Ingelmo, Ivani, Ivani, Ivani, Ivani, Jahr, Jaksch, José María, Ju, Jöhr, Kamata, Kart, Kimiaei Asadi, Kokki, Kokki, Kokki, Kokki, Koppert, Kost-Byerly, Kost-Byerly, Kubica-Cielińska, Kumar, Kurihara, Kwak, Lam, Laskowski, Lavonas, Leclair, Lee, Leksowski, Leoni, Litalien, Liu, Liu, Lorenzo, Lundeberg, Lönnqvist, Lönnqvist, Lönnqvist, Manworren, Marel, Marhofer, Mazoit, McNicol, Merry, Messerer, Messerer, Miller, Miró, Mobley, Mohammed, Momeni, Moriceau, Morton, Morton, Mukherjee, Müller, Mędrzycka-Dąbrowska, O'Sullivan, Olkkola, Orange, Ousley, Pace, Park, Park, Pasero, Petrat, Pierce, Polaner, Qian, Rabbitts, Redmann, Richer, Rugyte, Sahin, Sammartino, Sandeman, Schnabel, Schnabel, Schug, Schug, Schug, Schultz-Machata, Sekhavat, She, Shirazi, Sng, Soh, Sola, Soulard, Southworth, Sowder, Spacek, Splinter, Stamer, Staschen, Steans, Steffen, Subramanyam, Suresh, Taheri, Tobias, Tsuchiya, Valizadeh, Voepel-Lewis, Walker, Walther-Larsen, Walther-Larsen, Wang, Weintraud, Willschke, Willschke, Willschke, Wilson, Wilson-Smith, Wininger, Wong, Wong, Xue, Xue, Yaster, Yildiz, Yung   +196 more
core   +1 more source

Antidote application: an educational system for treatment of common toxin overdose [PDF]

, 2017
Poisonings account for almost 1% of emergency room visits each year. Time is a critical factor in dealing with a toxicologic emergency. Delay in dispensing the first antidote dose can lead to life-threatening sequelae.
Brusic, V., Chitkushev, L., Long, J., Zhang, G., Zhang, Y.   +4 more
core  

Pharmaceutical and personal care products-induced stress symptoms and detoxification mechanisms in cucumber plants. [PDF]

, 2018
Contamination of agricultural soils by pharmaceutical and personal care products (PPCPs) resulting from the application of treated wastewater, biosolids and animal wastes constitutes a potential environmental risk in many countries.
Dudley, Stacia, Gan, Jay, Sun, Chengliang, Trumble, John   +3 more
core   +1 more source

Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats.

PLoS ONE, 2021
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.
Navneet Suda, Jasmine Cendejas Hernandez, John Poulton, John P Jones, Zacharoula Konsoula, Caroline Smith, William Parker   +6 more
doaj   +1 more source

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. [PDF]

, 2019
Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often serves as a model for drug-induced liver injury in humans.
Hunt, C Anthony, Jaeschke, Hartmut, Kennedy, Ryan C, McGill, Mitchell R, Ropella, Glen EP, Smith, Andrew K   +5 more
core  

Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder

Life
More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal and spatial associations indicate that numerous genetic and ...
John P. Jones, Lauren Williamson, Zacharoula Konsoula, Rachel Anderson, Kathryn J. Reissner, William Parker   +5 more
doaj   +1 more source

Postnatal Acetaminophen and Potential Risk of Autism Spectrum Disorder among Males

Behavioral Sciences, 2020
Some evidence from the literature suggests that postnatal acetaminophen exposure may be associated with increased risk of autism spectrum disorder (ASD). Using a data set obtained from a previous study that was derived from an Internet-based survey among
Seth S. Bittker, Kathleen R. Bell
doaj   +1 more source

Limited post-operative narcotic use in elective laparoscopic cholecystectomy [PDF]

, 2017
Purpose: To limit narcotics use Cochrane review: multiple studies have shown postoperative pain can be managed with non-narcotic meds with good outcome Less medication related side effects:N/V, constipation, disorientation Prevents substance addiction ...
Josloff, MD, Robert, Noonan, MD, Kristin, Olszewski, MD, Tanya, Senthil-Kumar, MD, Prabhu   +3 more
core   +1 more source

Ten-Year Anniversary of Brownfields Legislation [PDF]

, 2008
OBJECTIVE:We hypothesized (1) that gastrointestinal (GI) and renal adverse events (AE) would occur more often in infants first prescribed ibuprofen before rather than after six months of age and (2) that ibuprofen would be associated with more adverse ...
Heejung Bang, Paul Walsh, Stephen J Rothenberg   +2 more
core   +2 more sources