Results 51 to 60 of about 113,832 (239)

Effect of Piperine Pretreatment on Biochemical Profiles of Acetaminophen-Induced Hepatotoxicity in Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Acetaminophen overdose is the most frequent cause of liver injuries. N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen induced by cytochrome P-450.
MT Kazemi, M Pour Nasrollah, MM Rezaei,, GH.A Jorsaraei, GH Maliji, S Kazemi, E Zabihi,, M Pouramir,, AA Moghadamnia   +8 more
doaj  

Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats.

PLoS ONE, 2021
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.
Navneet Suda, Jasmine Cendejas Hernandez, John Poulton, John P Jones, Zacharoula Konsoula, Caroline Smith, William Parker   +6 more
doaj   +1 more source

Acetaminophen Toxicity [PDF]

Journal of education & teaching in emergency medicine
This is a practice structured interview case which is appropriate for emergency medicine residents at all levels of training.Acetaminophen (APAP) is an over-the-counter medication commonly used by adult and pediatric populations. While acetaminophen has demonstrated to be reasonably safe and well-tolerated at therapeutic doses, it can cause severe ...
Whittaker, Rachel, Cheema, Navneet
openaire   +2 more sources

Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

EBioMedicine, 2018
Background: Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of action, and concern about the possibility of adverse effects on reproductive health.
Isaac V. Cohen, Elizabeth T. Cirulli, Matthew W. Mitchell, Thomas J. Jonsson, James Yu, Naisha Shah, Tim D. Spector, Lining Guo, J. Craig Venter, Amalio Telenti   +9 more
doaj   +1 more source

Postnatal Acetaminophen and Potential Risk of Autism Spectrum Disorder among Males

Behavioral Sciences, 2020
Some evidence from the literature suggests that postnatal acetaminophen exposure may be associated with increased risk of autism spectrum disorder (ASD). Using a data set obtained from a previous study that was derived from an Internet-based survey among
Seth S. Bittker, Kathleen R. Bell
doaj   +1 more source

Comparison of Therapeutic Effect and Safety of Oral and Rectal Use of Acetaminophen on Patent Ductus Arteriosus in Preterm Infants: Clinical Randomized Trial

Global Pediatric Health, 2023
The prevalence of patent ductus arteriosus (PDA) in preterm infants is high. There is little information about the therapeutic effect and safety of rectal acetaminophen in the treatment of PDA.
Mazyar Vakiliamini MD, Hooman Daryoushi MD, Homa Babaei MD, Roya Chegene Lorestani MSc, Mosayeb Rostamian PhD, Alisha Akya PhD, Reza Habibi MD, Keyghobad Ghadiri MD   +7 more
doaj   +1 more source

Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder

Life
More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal and spatial associations indicate that numerous genetic and ...
John P. Jones, Lauren Williamson, Zacharoula Konsoula, Rachel Anderson, Kathryn J. Reissner, William Parker   +5 more
doaj   +1 more source

Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort.

Paediatric and Perinatal Epidemiology, 2019
BACKGROUND Previous studies of prenatal acetaminophen use have not addressed what indications and maternal co-factors describe acetaminophen use.
G. Bandoli, K. Palmsten, C. Chambers
semanticscholar   +1 more source

Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila

Scientific Reports, 2022
Acetaminophen is the most common cause of acute drug-induced liver injury in the United States. However, research into the mechanisms of acetaminophen toxicity and the development of novel therapeutics is hampered by the lack of robust, reproducible, and
Bejan J. Saeedi, Sarah Hunter-Chang, Liping Luo, Kaiyan Li, Ken H. Liu, Brian S. Robinson   +5 more
doaj   +1 more source

Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose.

PLoS ONE, 2020
Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western world.
Sarah Piel, Imen Chamkha, Adam Kozak Dehlin, Johannes K Ehinger, Fredrik Sjövall, Eskil Elmér, Magnus J Hansson   +6 more
doaj   +1 more source