Results 41 to 50 of about 1,585,206 (294)

Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids [PDF]

New England Journal of Medicine, 2012
The efficacy and side-effect profile of ulipristal acetate as compared with those of leuprolide acetate for the treatment of symptomatic uterine fibroids before surgery are unclear.In this double-blind noninferiority trial, we randomly assigned 307 patients with symptomatic fibroids and excessive uterine bleeding to receive 3 months of daily therapy ...
Donnez J1, Tomaszewski J, Vázquez F, Bouchard P, Lemieszczuk B, Baró F, Nouri K, Selvaggi L, Sodowski K, Bestel E, Terrill P, Osterloh I, Loumaye E, THE PEARL II Study Group, MELIS, GIAN BENEDETTO   +14 more
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model

Frontiers in Endocrinology, 2018
Background and aimsGut-derived short-chain fatty acids (SCFA), formed by microbial fermentation of dietary fibers, are believed to be involved in the etiology of obesity and diabetes.
Johan W. E. Jocken, Johan W. E. Jocken, Manuel A. González Hernández, Nicole T. H. Hoebers, Christina M. van der Beek, Christina M. van der Beek, Yvonne P. G. Essers, Ellen E. Blaak, Ellen E. Blaak, Emanuel E. Canfora, Emanuel E. Canfora   +10 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Synthesis and crystal structure of one new Pb(II) complex constructed by 1,10-phenanthroline and two carboxylate ligands

Main Group Metal Chemistry, 2021
The complex [Pb(phen)(4-NB)(CH3COO)] of lead(II) was prepared and characterized by means of elemental analysis, FT-IR, and single crystal X-ray analysis, where phen = 1,10-phenanthroline, 4-NB = 4-nitrobenzoate.
Zhang Lu-Lin, Tang Shi-Li, Li De-Jun, Cheng Yuan-Zheng, Zhang Li-Ping   +4 more
doaj   +1 more source

Tunneling Splittings in Mn12-Acetate Single Crystals [PDF]

, 2002
A Landau-Zener multi-crossing method has been used to investigate the tunnel splittings in high quality Mn$_{12}$-acetate single crystals in the pure quantum relaxation regime and for fields applied parallel to the magnetic easy axis.
, A. D Kent, Chudnovsky E. M., Cornia A., D. N Hendrickson, del Barco E., E. del Barco, E. M Rumberger, G Christou, Hernandez, Hernandez J. M., Torres F., Wernsdorfer W.   +12 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Role of Active Site Residues in ATP Binding and Catalysis in the Methanosarcina thermophila Acetate Kinase

Life, 2015
Acetate kinase (ACK), which catalyzes the reversible phosphorylation of acetate by ATP, is a member of the acetate and sugar kinase/heat shock cognate/actin (ASKHA) superfamily. ASKHA family members share a common core fold that includes an ATPase domain
Cheryl Ingram-Smith, Jeffrey Wharton, Christian Reinholz, Tara Doucet, Rachel Hesler, Kerry Smith   +5 more
doaj   +1 more source

5α-Dihydrovespertilin acetate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(24)H(36)O(4) [systematic name: (20S)-3β-acet-oxy-16α-hydr-oxy-22,23-bis-nor-5α,17β-cholano(22-16)lac-tone], the three six-membered rings adopt classical chair conformations, while the five-membered rings are in envelope conformations. The ester group attached to ring A is in an equatorial position.
Benn, Michael, Vohra, Kanwal Nain, Parvez, Masood   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source