Results 1 to 10 of about 160,774 (308)

Elevated propionate and its association with neurological dysfunctions in propionic acidemia

Frontiers in Molecular Neuroscience
Propionate, a short-chain fatty acid (SCFA), has recently attracted attention for its various health benefits. However, elevated levels of propionate in certain pathological conditions can have adverse effects. Propionic acidemia (PA) is a rare metabolic
Xiaoxin Chen, Xiaoxin Chen, Xiaoxin Chen, Qing Cheng, Guo-Fang Zhang, Guo-Fang Zhang   +5 more
doaj   +3 more sources

Effect of Feeding Discarded Durian Peel Ensiled with Lactobacillus casei TH14 and Additives in Total Mixed Rations on Digestibility, Ruminal Fermentation, Methane Mitigation, and Nitrogen Balance of Thai Native–Anglo-Nubian Goats

Fermentation, 2022
The objective of this study was to evaluate the effect of fermented discarded durian peel with Lactobacillus casei TH14, cellulase, and molasses separately or in combination in total mixed rations on feed utilization, digestibility, ruminal fermentation,
Natcha Panyawoot, Sarong So, Anusorn Cherdthong, Pin Chanjula   +3 more
doaj   +1 more source

Protective role of colitis in inflammatory arthritis via propionate-producing Bacteroides in the gut

Frontiers in Immunology, 2023
ObjectivesTo investigate whether and how inflammatory disease in the intestine influences the development of arthritis, considering that organ-to-organ communication is associated with many physiological and pathological events.MethodsFirst, mice were ...
Hoh-Jeong Shon, Hoh-Jeong Shon, Yu-Mi Kim, Yu-Mi Kim, Kyeong Seog Kim, Kyeong Seog Kim, Jin-Ouk Choi, Jin-Ouk Choi, Sang-Hyun Cho, Sujin An, Sujin An, Se-Hyeon Park, Se-Hyeon Park, Yong-Joon Cho, Yong-Joon Cho, Yong-Joon Cho, Joo-Hong Park, Sang-Uk Seo, Joo-Youn Cho, Joo-Youn Cho, Wan-Uk Kim, Wan-Uk Kim, Wan-Uk Kim, Donghyun Kim, Donghyun Kim, Donghyun Kim   +25 more
doaj   +1 more source

Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

EBioMedicine, 2021
The gut microbiome and the intestinal immune system are driving contributors to inflammatory bowel diseases (IBD). Both have an important signalling factor in common: short-chain fatty acids (SCFAs).
Sara Deleu, Kathleen Machiels, Jeroen Raes, Kristin Verbeke, Séverine Vermeire   +4 more
doaj   +1 more source

Propionate and Alzheimer’s Disease [PDF]

Frontiers in Aging Neuroscience, 2021
Propionate, a short-chain fatty acid, serves important roles in the human body. However, our review of the current literature suggests that under certain conditions, excess levels of propionate may play a role in Alzheimer’s disease (AD). The cause of the excessive levels of propionate may be related to the Bacteroidetes phylum, which are the primary ...
Jessica Killingsworth, Darrell Sawmiller, R. Douglas Shytle   +2 more
openaire   +3 more sources

Prediction of high fecal propionate-to-butyrate ratios using 16S rRNA-based detection of bacterial groups with liquid array diagnostics

BioTechniques, 2023
Butyrate and propionate represent two of three main short-chain fatty acids produced by the intestinal microbiota. In healthy populations, their levels are reportedly equimolar, whereas a deviation in their ratio has been observed in various diseased ...
Pranvera Hiseni, Lars Snipen, Robert C Wilson, Kari Furu, Finn Terje Hegge, Knut Rudi   +5 more
doaj   +1 more source

AG1, A Novel Synbiotic, Demonstrates the Capability to Enhance Fermentation Using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME^®)

Biology and Life Sciences Forum, 2023
Synbiotics, a combination of prebiotics and probiotics, are growing in popularity, with consumers desiring improved gastrointestinal health. Prebiotics are non-digestible nutrients that can be metabolized by microbiota to exert a beneficial effect, while
Trevor O. Kirby, Jeremy R. Townsend, Philip A. Sapp, Marlies Govaert, Cindy Duysburgh, Massimo Marzorati, Tess M. Marshall, Ralph Esposito   +7 more
doaj   +1 more source

The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset

Gut Microbes, 2023
Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases.
Takashi Ito, Yumiko Nakanishi, Ryohei Shibata, Noriko Sato, Toshi Jinnohara, Sayo Suzuki, Wataru Suda, Masahira Hattori, Ikuo Kimura, Taiji Nakano, Fumiya Yamaide, Naoki Shimojo, Hiroshi Ohno   +12 more
doaj   +1 more source

Association of plasma propionate concentration with coronary artery disease in a large cross-sectional study

Frontiers in Cardiovascular Medicine, 2023
BackgroundMicrobiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association of short-chain fatty acids (SCFA) with CAD are lacking.
Nikolaos Pagonas, Nikolaos Pagonas, Nikolaos Pagonas, Felix S. Seibert, Gerhard Liebisch, Maximillian Seidel, Theodoros Giannakopoulos, Benjamin Sasko, Benjamin Sasko, Oliver Ritter, Oliver Ritter, Nina Babel, Timm H. Westhoff   +12 more
doaj   +1 more source

Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation

JACC: Basic to Translational Science, 2022
Summary: Emerging evidence supports that intestinal microbial metabolite short-chain fatty acids (SCFAs) increase the pool of regulatory T cells (Tregs) in the colonic lamina propria (cLP) and protect against nonintestinal inflammatory diseases, such as ...
Fen Yang, MD, Ni Xia, MD, PhD, Shuang Guo, MD, Jiyu Zhang, MS, Yuhan Liao, MS, Tingting Tang, MD, PhD, Shaofang Nie, MD, PhD, Min Zhang, MD, PhD, Bingjie Lv, MD, Yuzhi Lu, MD, PhD, Jiao Jiao, MD, PhD, Jingyong Li, MD, PhD, Weimin Wang, PhD, Desheng Hu, MD, PhD, Xiang Cheng, MD, PhD   +14 more
doaj   +1 more source