Results 11 to 20 of about 179,024 (208)

Propionate and Alzheimer’s Disease [PDF]

Frontiers in Aging Neuroscience, 2021
Propionate, a short-chain fatty acid, serves important roles in the human body. However, our review of the current literature suggests that under certain conditions, excess levels of propionate may play a role in Alzheimer’s disease (AD).
Darrell Sawmiller, R Douglas Shytle
exaly   +5 more sources

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

Cell, 2018
Interactions between the gut microbiota, diet, and the host potentially contribute to the development of metabolic diseases. Here, we identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher ...
Ara Koh, Antonio Molinaro, Marcus Stahlman   +2 more
exaly   +2 more sources

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Cell Metabolism, 2020
Summary Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes
Ara Koh, Na-Oh Yunn, Peter M Nilsson
exaly   +2 more sources

Propionate attenuates osteoarthritis progression by regulating the gut-joint axis [PDF]

Frontiers in Immunology
IntroductionOsteoarthritis (OA) is a degenerative joint disorder characterized by cartilage degradation, inflammation, and pain. Growing evidence indicates that dysregulation of the gut–joint axis contributes to OA progression.
Segyeong Han, Segyeong Han, Segyeong Han, Keun-Hyung Cho, Hyun Sik Na, Hyun Sik Na, JooYeon Jhun, JooYeon Jhun, Young-Mee Moon, Young-Mee Moon, Jeong Won Choi, Jeong Won Choi, Jeong Won Choi, Seok Jung Kim, Mi-La Cho, Mi-La Cho, Mi-La Cho   +16 more
doaj   +2 more sources

Novel insights into the anaerobic digestion of propionate via Syntrophobacter fumaroxidans and Geobacter sulfurreducens: Process and mechanism

Water Research, 2021
The accumulation of volatile fatty acids, particularly propionic acid, significantly inhibits the efficiency of the anaerobic digestion system. In propionate degradation metabolism, the unfavorable thermodynamics of syntrophic reactions, strict ...
Gefu Zhu, Jianbo Jia, Changyu Liu
exaly   +2 more sources

Propionate alleviates fatty acid–induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes

Journal of Dairy Science, 2022
: Reduced feed intake during the transition period renders cows unable to meet their energy needs for maintenance and lactation, leading to a state of negative energy balance.
Xinghui Wang, Mengyao Zhu, Juan J. Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei Li   +12 more
doaj   +2 more sources

Elevated propionate and its association with neurological dysfunctions in propionic acidemia

Frontiers in Molecular Neuroscience
Propionate, a short-chain fatty acid (SCFA), has recently attracted attention for its various health benefits. However, elevated levels of propionate in certain pathological conditions can have adverse effects. Propionic acidemia (PA) is a rare metabolic
Xiaoxin Chen, Xiaoxin Chen, Xiaoxin Chen, Qing Cheng, Guo-Fang Zhang, Guo-Fang Zhang   +5 more
doaj   +3 more sources

Propionate-Producing Consortium Restores Antibiotic-Induced Dysbiosis in a Dynamic in vitro Model of the Human Intestinal Microbial Ecosystem

Frontiers in Microbiology, 2019
Metabolic syndrome is a growing public health concern. Efforts at searching for links with the gut microbiome have revealed that propionate is a major fermentation product in the gut with several health benefits toward energy homeostasis.
Racha El Hage, Emma Hernandez-Sanabria, Marta Calatayud Arroyo, Ruben Props, Tom Van de Wiele   +4 more
doaj   +2 more sources

Mediterranean diet enhances endurance training adaptation through gut microbiota-derived short-chain fatty acids [PDF]

Frontiers in Nutrition
BackgroundThe concept of the gut microbiota and short-chain fatty acids (SCFAs) has emerged. Although the Mediterranean diet has beneficial effects on the composition of the gut microbiota and the production SCFA, it has not been shown to affect the ...
Cheng Lu, Chuan Liu, Gang Qin, Guangqing Song   +3 more
doaj   +2 more sources

Effect of Feeding Discarded Durian Peel Ensiled with Lactobacillus casei TH14 and Additives in Total Mixed Rations on Digestibility, Ruminal Fermentation, Methane Mitigation, and Nitrogen Balance of Thai Native–Anglo-Nubian Goats

Fermentation, 2022
The objective of this study was to evaluate the effect of fermented discarded durian peel with Lactobacillus casei TH14, cellulase, and molasses separately or in combination in total mixed rations on feed utilization, digestibility, ruminal fermentation,
Natcha Panyawoot, Sarong So, Anusorn Cherdthong, Pin Chanjula   +3 more
doaj   +1 more source