Results 21 to 30 of about 179,024 (208)

Protective role of colitis in inflammatory arthritis via propionate-producing Bacteroides in the gut

Frontiers in Immunology, 2023
ObjectivesTo investigate whether and how inflammatory disease in the intestine influences the development of arthritis, considering that organ-to-organ communication is associated with many physiological and pathological events.MethodsFirst, mice were ...
Hoh-Jeong Shon, Hoh-Jeong Shon, Yu-Mi Kim, Yu-Mi Kim, Kyeong Seog Kim, Kyeong Seog Kim, Jin-Ouk Choi, Jin-Ouk Choi, Sang-Hyun Cho, Sujin An, Sujin An, Se-Hyeon Park, Se-Hyeon Park, Yong-Joon Cho, Yong-Joon Cho, Yong-Joon Cho, Joo-Hong Park, Sang-Uk Seo, Joo-Youn Cho, Joo-Youn Cho, Wan-Uk Kim, Wan-Uk Kim, Wan-Uk Kim, Donghyun Kim, Donghyun Kim, Donghyun Kim   +25 more
doaj   +1 more source

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Nature, 2022
The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate1. Regenerative ability is influenced by both injury-dependent and injury-independent mechanisms2.
Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, G. Kong, Luming Zhou, Greg Crawford, M. Danzi, A. Myridakis, A. Brandis, Adesola T. Bello, Franziska Müller, Alexandros Sanchez-Vassopoulos, Francesco De Virgiliis, Phoebe Liddell, M. Dumas, J. Strid, S. Mani, Dylan Dodd, S. Di Giovanni   +18 more
semanticscholar   +1 more source

Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

EBioMedicine, 2021
The gut microbiome and the intestinal immune system are driving contributors to inflammatory bowel diseases (IBD). Both have an important signalling factor in common: short-chain fatty acids (SCFAs).
Sara Deleu, Kathleen Machiels, Jeroen Raes, Kristin Verbeke, Séverine Vermeire   +4 more
doaj   +1 more source

Prediction of high fecal propionate-to-butyrate ratios using 16S rRNA-based detection of bacterial groups with liquid array diagnostics

BioTechniques, 2023
Butyrate and propionate represent two of three main short-chain fatty acids produced by the intestinal microbiota. In healthy populations, their levels are reportedly equimolar, whereas a deviation in their ratio has been observed in various diseased ...
Pranvera Hiseni, Lars Snipen, Robert C Wilson, Kari Furu, Finn Terje Hegge, Knut Rudi   +5 more
doaj   +1 more source

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.

European Heart Journal, 2021
AIMS Atherosclerotic cardiovascular disease (ACVD) is a major cause of mortality and morbidity worldwide, and increased low-density lipoproteins (LDLs) play a critical role in development and progression of atherosclerosis.
A. Haghikia, Friederike Zimmermann, P. Schumann, A. Jasina, J. Roessler, D. Schmidt, Philipp Heinze, Johannes Kaisler, V. Nageswaran, A. Aigner, U. Ceglarek, Roodline Cineus, A. Hegazy, Emiel P. C. van der Vorst, Y. Döring, Christopher M Strauch, I. Nemet, V. Tremaroli, Chinmay Dwibedi, N. Kränkel, D. Leistner, M. Heimesaat, S. Bereswill, G. Rauch, U. Seeland, O. Soehnlein, D. Müller, R. Gold, F. Bäckhed, S. Hazen, Aiden Haghikia, U. Landmesser   +31 more
semanticscholar   +1 more source

AG1, A Novel Synbiotic, Demonstrates the Capability to Enhance Fermentation Using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME^®)

Biology and Life Sciences Forum, 2023
Synbiotics, a combination of prebiotics and probiotics, are growing in popularity, with consumers desiring improved gastrointestinal health. Prebiotics are non-digestible nutrients that can be metabolized by microbiota to exert a beneficial effect, while
Trevor O. Kirby, Jeremy R. Townsend, Philip A. Sapp, Marlies Govaert, Cindy Duysburgh, Massimo Marzorati, Tess M. Marshall, Ralph Esposito   +7 more
doaj   +1 more source

Syntrophic entanglements for propionate and acetate oxidation under thermophilic and high-ammonia conditions

The ISME Journal, 2023
Propionate is a key intermediate in anaerobic digestion processes and often accumulates in association with perturbations, such as elevated levels of ammonia. Under such conditions, syntrophic ammonia-tolerant microorganisms play a key role in propionate
Abhijeet Singh, A. Schnürer, Jan Dolfing, M. Westerholm   +3 more
semanticscholar   +1 more source

The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset

Gut Microbes, 2023
Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases.
Takashi Ito, Yumiko Nakanishi, Ryohei Shibata, Noriko Sato, Toshi Jinnohara, Sayo Suzuki, Wataru Suda, Masahira Hattori, Ikuo Kimura, Taiji Nakano, Fumiya Yamaide, Naoki Shimojo, Hiroshi Ohno   +12 more
doaj   +1 more source

Syntrophic Propionate Oxidation: One of the Rate-Limiting Steps of Organic Matter Decomposition in Anoxic Environments

Applied and Environmental Microbiology, 2023
Syntrophic propionate oxidation is one of the rate-limiting steps during anaerobic decomposition of organic matter in anoxic environments. Syntrophic propionate-oxidizing bacteria (SPOB) are members of the “rare biosphere” living at the edge of the ...
Yidan Jin, Yahai Lu
semanticscholar   +1 more source

Association of plasma propionate concentration with coronary artery disease in a large cross-sectional study

Frontiers in Cardiovascular Medicine, 2023
BackgroundMicrobiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association of short-chain fatty acids (SCFA) with CAD are lacking.
Nikolaos Pagonas, Nikolaos Pagonas, Nikolaos Pagonas, Felix S. Seibert, Gerhard Liebisch, Maximillian Seidel, Theodoros Giannakopoulos, Benjamin Sasko, Benjamin Sasko, Oliver Ritter, Oliver Ritter, Nina Babel, Timm H. Westhoff   +12 more
doaj   +1 more source