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The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity

Frontiers in Nutrition, 2022
Intestinal environment disorder is a potential pathological mechanism of obesity. There is increasing evidence that disorders in the homeostasis of the intestinal environment can affect various metabolic organs, such as fat and liver, and lead to ...
Zhengquan Su, Hua Cao, Jiao Guo
exaly   +6 more sources

The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women [PDF]

International Journal of Molecular Sciences, 2020
Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure,
Malgorzata Szczuko, Dominika Maciejewska-Markiewicz, Zbigniew Celewicz   +2 more
exaly   +4 more sources

Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation

Nutrients, 2020
Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro- and anti-inflammatory mediators in the joints, thereby favoring chronic ...
Sébastien Lucas, Georg Schett, Juergen Rech   +2 more
exaly   +2 more sources

Sources of Dietary Fiber Affect the SCFA Production and Absorption in the Hindgut of Growing Pigs

Frontiers in Nutrition, 2022
Effects of different dietary fiber (DF) sources on short-chain fatty acids (SCFA) production and absorption in the hindgut of growing pigs were studied by an in vivo–vitro (ileal cannulated pigs and fecal inoculum-based fermentation) method.
Shuai Zhang, Dandan Han, Dongsheng Che   +2 more
exaly   +2 more sources

Dietary Fiber Treatment Corrects the Composition of Gut Microbiota, Promotes SCFA Production, and Suppresses Colon Carcinogenesis

Genes, 2018
Epidemiological studies propose a protective role for dietary fiber in colon cancer (CRC). One possible mechanism of fiber is its fermentation property in the gut and ability to change microbiota composition and function. Here, we investigate the role of
Faraz Bishehsari, Bruce Hamaker, Preite Nz   +2 more
exaly   +2 more sources

SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome

Nature Communications
Type 1 diabetes (T1D) is linked to an altered gut microbiota characterized by reduced short-chain fatty acid (SCFA) production. Oral delivery of a SCFA-yielding biotherapy in adults with T1D was followed by increased SCFAs, altered gut microbiota and ...
Bree J. Tillett, Jacky Dwiyanto, Kate R. Secombe, Thomas George, Vivian Zhang, Dovile Anderson, Emily Duggan, Rabina Giri, Dorothy Loo, Thomas Stoll, Mark Morrison, Jakob Begun, Michelle M. Hill, Esteban N. Gurzov, Kirstine J. Bell, Sonia Saad, Christopher K. Barlow, Darren J. Creek, Chun Wie Chong, Eliana Mariño, Emma E. Hamilton-Williams   +20 more
doaj   +2 more sources

Production of Organic Acid and Short-Chain Fatty Acids (SCFA) from Lactic Acid Bacteria Isolate on Oligosaccharide Media

Jurnal Kimia Sains dan Aplikasi, 2021
The growth of microorganisms in food, one of which is lactic acid bacteria (LAB), can produce metabolites beneficial to health. It is essential to study the results of LAB metabolism to improve the quality of a functional food product.
Yati Maryati, Lilis Nuraida, Ratih Dewanti Hariyadi   +2 more
doaj   +1 more source

Pilot study on gut microbiota profile in Indian children with type 1 diabetes

Indian Journal of Endocrinology and Metabolism, 2023
Background: Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM).
Nikhil Shah, Abhijit Kulkarni, Dattatray Mongad, Kunal Jaani, Neha Kajale, Vaishali Tamahane, Shital Bhor, Dipali Ladkat, Vaman Khadilkar, Ketan Gondhalekar, Yogesh Shouche, Anuradha V Khadilkar   +11 more
doaj   +1 more source

Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease.

Redox Biology, 2023
The brain is particularly susceptible to oxidative damage which is a key feature of several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease.
Yan Sun, Huaiwu Zhang, Xuan Zhang, Wenzhao Wang, Yong Chen, Z. Cai, Qihui Wang, J. Wang, Yi Shi   +8 more
semanticscholar   +1 more source

Nourishing Immunity and Combatting Neuroinflammation: The Power of Immunonutrition and The Microbiome

Frontiers in Bioscience-Landmark, 2023
The gut-microbiome-brain axis plays a crucial role in the control of systemic metabolism and homeostasis. Recent research has shown that dietary habits and nutrients can affect immune system and inflammatory status by influencing various factors ...
Eda Nur Dübüş, Ingrid Lamminpää, Giulia Nannini, Elena Niccolai   +3 more
doaj   +1 more source