Results 11 to 20 of about 63,687 (336)

Microbiota and SCFA in Lean and Overweight Healthy Subjects [PDF]

Obesity, 2010
Obesity has recently been linked to the composition of human microbiota and the production of short chain fatty acids (SCFAs). However, these findings rely on experimental studies carried out using rather small and defined groups of volunteers or model animals.
Schwiertz, Andreas, Taras, David, Schaefer, Klaus, Beijer, Silvia, Bos, Nicolaas A., Donus, Christiane, Hardt, Philip D.   +6 more
core   +5 more sources

SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome

Nature Communications
Type 1 diabetes (T1D) is linked to an altered gut microbiota characterized by reduced short-chain fatty acid (SCFA) production. Oral delivery of a SCFA-yielding biotherapy in adults with T1D was followed by increased SCFAs, altered gut microbiota and ...
Bree J. Tillett, Jacky Dwiyanto, Kate R. Secombe, Thomas George, Vivian Zhang, Dovile Anderson, Emily Duggan, Rabina Giri, Dorothy Loo, Thomas Stoll, Mark Morrison, Jakob Begun, Michelle M. Hill, Esteban N. Gurzov, Kirstine J. Bell, Sonia Saad, Christopher K. Barlow, Darren J. Creek, Chun Wie Chong, Eliana Mariño, Emma E. Hamilton-Williams   +20 more
doaj   +3 more sources

Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation [PDF]

Iranian Journal of Microbiology, 2019
Background and Objectives: Gut microbiota influences our health via multiple mechanisms. Microbiota produced Short Chain Fatty Acid (SCFA) as an energy to maintain gut ecosystem and physiology.
Pratiwi Dyah Kusumo, Hasan Maulahela, Amanda Pitarini Utari, Ingrid S. Surono, Amin Soebandrio, Murdani Abdullah   +5 more
doaj   +3 more sources

Do SCFA have a role in appetite regulation? [PDF]

Proceedings of the Nutrition Society, 2011
The recently discovered SCFA-activated G-coupled protein receptors FFA receptor 2 and FFA receptor 3 are co-localised inl-cells with the anorexigenic ‘ileal brake’ gut hormone peptide YY, and also in adipocytes, with activation stimulating leptin release.
Darzi, J, Frost, GS, Robertson, MD
core   +6 more sources

The gut microbiota-SCFA-inflammation axis in patients with AECOPD

PLOS ONE
Objectives The aim of the study was to explore the alteration of microbiota and SCFA in gut and inflammation in acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients, and to test the hypothesis that a disorder of gut microbiota will lead to the alteration of SCFA, which will aggravate inflammation in AECOPD patients. Methods and
Hengjing Zhu, Chen Wu, Haiyan Wu, Juan Liu, Wu Ye, Tian Zhao, Zhijun Li   +6 more
openaire   +4 more sources

FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology

Metabolites, 2021
The gut microbiome has emerged as a novel determinant of type 1 diabetes (T1D), but the underlying mechanisms are unknown. In this context, major gut microbial metabolites, short-chain fatty acids (SCFAs), are considered to be an important link between ...
Kristen Lednovich, Brian T. Layden, Sophie Gough, Medha Priyadarshini, Kai Xu, Barton Wicksteed   +5 more
core   +2 more sources

A novel SCFA receptor, the microbiota, and blood pressure regulation [PDF]

Gut Microbes, 2013
The maintenance of blood pressure homeostasis is a complex process which is carefully regulated by a variety of inputs. We recently identified two sensory receptors (Olfactory receptor 78 and G protein couple receptor 41) as novel regulators of blood pressure.
J. Pluznick
openaire   +3 more sources

Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?

Proceedings of the Nutrition Society, 2015
In recent years, there has been a renewed interest in the role of dietary fibre in obesity management. Much of this interest stems from animal and human studies which suggest that an increased intake of fermentable fibre can suppress appetite and improve
Frost, Gary, Morrison, Douglas J., Chambers, Edward S.   +2 more
core   +2 more sources

Kiwifruit fibre level influences the predicted production and absorption of SCFA in the hindgut of growing pigs using a combined in vivo-in vitro digestion methodology

British Journal of Nutrition, 2015
Combined in vivo (ileal cannulated pig) and in vitro (faecal inoculum-based fermentation) digestion methodologies were used to predict the production and absorption of SCFA in the hindgut of growing pigs.
Moughan PJ, Montoya CA, Rutherfurd S
core   +2 more sources

Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease.

Redox Biology, 2023
The brain is particularly susceptible to oxidative damage which is a key feature of several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease.
Yan Sun, Huaiwu Zhang, Xuan Zhang, Wenzhao Wang, Yong Chen, Z. Cai, Qihui Wang, J. Wang, Yi Shi   +8 more
semanticscholar   +1 more source