Results 41 to 50 of about 58,221 (301)

The therapeutic potential of short-chain fatty acids enemas in inflammatory bowel diseases: a systematic review [PDF]

Farmacja Polska, 2020
It has been suggested that short-chain fatty acid (SCFA) enemas might improve clinical, endoscopic and histological scores in patients with inflammatory bowel disease.
Nina Kaczmarek, Marta Kokot, Aleksandra Makarewicz, Aleksandra Glapa-Nowak, Jan Krzysztof Nowak, Małgorzata Jamka, Jarosław Walkowiak   +6 more
doaj   +1 more source

Probiotic Lactobacillus reuteri DSM 17938: what is known about it today?

Медицинский совет, 2019
The review is devoted to the analysis of data on the effects of Lactobacillus reuteri DSM 17938, confirmed in clinical trials. Thanks to their antimicrobial activity, L. reuteri is able to inhibit colonization by pathogenic microorganisms and restore the
I. N. Zakharova, I. V. Berezhnaya, A. Е. Kuchina, O. V. Dedikova   +3 more
doaj   +1 more source

The Effects of Short-Chain Fatty Acids in Urological Diseases [PDF]

Urogenital Tract Infection, 2022
The gut microbiome, believed to serve as a second genome within the human body, is involved in the regulation of several metabolic processes. These include human gene expression, development, nutrition and homeostasis.
Hee Jo Yang, Doo Sang Kim
doaj   +1 more source

Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota

Gut Microbes, 2020
Dietary fibers are considered beneficial nutrients for health. Current data suggest that their interaction with the gut microbiota largely contributes to their physiological effects.
Julie Rodriguez, Audrey M. Neyrinck, Zhengxiao Zhang, Benjamin Seethaler, Julie-Anne Nazare, Cándido Robles Sánchez, Martin Roumain, Giulio G. Muccioli, Laure B. Bindels, Patrice D. Cani, Véronique Maquet, Martine Laville, Stephan C. Bischoff, Jens Walter, Nathalie M. Delzenne   +14 more
doaj   +1 more source

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

eLife, 2021
Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s disease (AD) progression. However, the mechanisms of microbiome–brain interaction in AD were so far unknown.
Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz   +21 more
doaj   +1 more source

FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology

Metabolites, 2021
The gut microbiome has emerged as a novel determinant of type 1 diabetes (T1D), but the underlying mechanisms are unknown. In this context, major gut microbial metabolites, short-chain fatty acids (SCFAs), are considered to be an important link between ...
M. Priyadarshini, Kristen R. Lednovich, Kai Xu, S. Gough, B. Wicksteed, B. Layden   +5 more
semanticscholar   +1 more source

SCFAs Take a Toll En Route to Metabolic Syndrome [PDF]

Cell Metabolism, 2015
Gut dysbiosis is associated with development of metabolic syndrome in Tlr5(-/-) mice, but the underlying mechanism remains unclear. In this issue, Singh et al. (2015) report that augmented SCFA levels play a deleterious role in metabolic syndrome by promoting conversion of SFA to oleate in Tlr5(-/-) mice via increased liver SCD1expression.
Marette, André, Jobin, Christian
openaire   +2 more sources

Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes

Frontiers in Endocrinology, 2022
AimGastrointestinal discomfort is the most common adverse event in metformin treatment for type 2 diabetes. The mechanism of action of metformin is associated with gut microbiota.
Yuxin Huang, Xudan Lou, Cuiping Jiang, Xueying Ji, Xiaoming Tao, Jiao Sun, Zhijun Bao   +6 more
doaj   +1 more source

Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis

EBioMedicine, 2022
Summary: Background: Gut microbiota-derived short-chain fatty-acid (SFCA) acetate protects mice against RSV A2 strain infection by increasing interferon-β production and expression of interferon-stimulated genes (ISGs).
Krist H. Antunes, Renato T. Stein, Caroline Franceschina, Emanuelle F. da Silva, Deise N. de Freitas, Josiane Silveira, Magáli Mocellin, Lidiane Leitão, José L. Fachi, Laís P. Pral, Amanda Gonzalez, Sarah Oliveira, Leonardo Duarte, Gisele Cassão, João I.B. Gonçalves, Tatiane M. Reis, Bruno L Abbadi, Maiele Dornelles, Nathália D.M. Sperotto, Maurício Rigo, Hosana Rodrigues, Marcus Jones, Matias Epifanio, Suzana Guima, João C. Setubal, Taissa R. Jorge, Daniel S. Mansur, Fabiana Q. Mayer, Ana Paula M. Varela, Cristiano V. Bizarro, Pablo Machado, Luiz A. Basso, Fernando P. Polack, Adnan Custovic, Marco A.R. Vinolo, Ana Paula D. de Souza   +35 more
doaj   +1 more source

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

Mucosal Immunology, 2018
The antimicrobial peptides (AMP) produced by intestinal epithelial cells (IEC) play crucial roles in the regulation of intestinal homeostasis by controlling microbiota.
Ye Zhao, Feidi Chen, Wei Wu, Mingming Sun, A. Bilotta, Suxia Yao, Yi Xiao, Xiangsheng Huang, T. Eaves-Pyles, G. Golovko, Y. Fofanov, Warren N D'Souza, Qihong Zhao, Zhanju Liu, Y. Cong   +14 more
semanticscholar   +1 more source