Results 41 to 50 of about 51,375 (256)

Cecal SCFA in mice after 8 weeks of feeding.

, 2016
SCFA (A), acetate (B), propionate (C), butyrate (D), BCFA (E), SCFA/SCFA ratio (F); data are presented as mean ± SEM; n = 8 mice/group for HF and LF; n = 4 mice/group for N-FOPS and F-FOPS; mouse numbers are shown for FOPS mice to track individual mice ...
Inés Martínez (236509), Junyi Yang (602557), Laure B. Bindels (155478), Devin J. Rose (843132), Amanda E. Ramer-Tait (192555), Rafael R. Segura Munoz (843131), Jens Walter (229801)   +6 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study. [PDF]

PLoS ONE, 2017
Environmental factors driving the development of type 1 diabetes (T1D) are still largely unknown. Both animal and human studies have shown an association between altered fecal microbiota composition, impaired production of short-chain fatty acids (SCFA ...
Pieter F de Groot, Clara Belzer, Ömrüm Aydin, Evgeni Levin, Johannes H Levels, Steven Aalvink, Fransje Boot, Frits Holleman, Daniël H van Raalte, Torsten P Scheithauer, Suat Simsek, Frank G Schaap, Steven W M Olde Damink, Bart O Roep, Joost B Hoekstra, Willem M de Vos, Max Nieuwdorp   +16 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets

Genes & Nutrition, 2019
Background The present study was conducted to investigate the effects of gastric infusion of short-chain fatty acids (SCFA) on gut barrier function in a pig model. In this study, 21 DLY barrows with an average initial body weight of (8.31 ± 0.72) kg were
H. Diao, A. R. Jiao, B. Yu, X. B. Mao, D. W. Chen   +4 more
doaj   +1 more source

The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats

Journal of Nutrition and Metabolism, 2023
Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites.
Hery D. Purnomo, Refani A. Kusuma, Elfrida Sianturi, Ryan F. Haroen, Muchamad R. Solichin, Choirun Nissa, Adriyan Pramono, Endang Mahati, Etika R. Noer   +8 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Exogenous Short Chain Fatty Acid Effects in APP/PS1 Mice

Frontiers in Neuroscience, 2022
Elucidating the impact of the gut microbiome on Alzheimer’s Disease (AD) is an area of intense interest. Short chain fatty acids (SCFAs) are major microbiota metabolites that have been implicated as a mediator of gut microbiome effects in the brain. Here,
Diana J. Zajac, Benjamin C. Shaw, David J. Braun, Stefan J. Green, Joshua M. Morganti, Steven Estus   +5 more
doaj   +1 more source

Overview of C. difficile metabolism with a focus on SCFA synthesis.

, 2021
Glycolysis, Stickland fermentation, TCA cycle, Wood–Ljungdahl pathway, and SCFA synthesis are underlined and presented in a simplified version for clarity; adapted from [77].
Anna L. Gregory (11592234), Andrew J. Hryckowian (11294445), Daniel A. Pensinger (3325794)   +2 more
core   +1 more source