Results 31 to 40 of about 29,036 (224)
Question Answering with Subgraph Embeddings [PDF]
, 2014 This paper presents a system which learns to answer questions on a broad range of topics from a knowledge base using few hand-crafted features. Our model learns low-dimensional embeddings of words and knowledge base constituents; these representations ...
Bordes, Antoine +2 more
core +2 more sources
Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers [PDF]
, 2018 Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3 - secretion to total cyclic adenosine monophosphate (cAMP ...
Avula, L.R. (Leela Rani) +6 more
core +5 more sources
Ataxia in children: early recognition and clinical evaluation [PDF]
, 2017 Background: Ataxia is a sign of different disorders involving any level of the nervous system and consisting of impaired coordination of movement and balance.
Falsaperla, Raffaele +6 more
core +1 more source
PulmonologyBackground The carbonic anhydrase inhibitor acetazolamide stimulates ventilation through metabolic acidosis mediated by renal bicarbonate excretion. In animal models, acetazolamide attenuates acute hypoxia-induced pulmonary hypertension (PH), but its ...
M. Lichtblau +11 more
doaj +1 more source
Efficacy of Acetazolamide in Refractory Epilepsy Management: A Quasi-Experimental Study
Pakistan Armed Forces Medical Journal, 2023 Objective: To assess the efficacy of Acetazolamide in refractory epilepsy management. Study Design: Quasi-experimental study. Place and Duration of Study: Outpatient Neurology Department, Allied Hospital, Faisalabad Pakistan, from Sep 2020 to Feb ...
Muhammad Ahmed Zamir +4 more
doaj +1 more source
Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
Evolution and diversity of alpha-carbonic anhydrases in the mantle of the Mediterranean mussel (Mytilus galloprovincialis) [PDF]
, 2019 The α-carbonic anhydrases (α-CAs) are a large and ancient group of metazoan-specific enzymes. They generate bicarbonate from metabolic carbon dioxide and through calcium carbonate crystal formation play a key role in the regulation of mineralized ...
Anjos, Liliana +6 more
core +1 more source
Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea
Chronic Diseases and Translational Medicine, EarlyView.Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy +3 more
wiley +1 more source
Effects of Acetazolamide on Collagen Metabolism in Keratoconus Fibroblasts
Taiyuan Ligong Daxue xuebao, 2023 Keratoconus is characterized by the progressive thinning and protrusion of central cornea. Dysregulated collagen metabolism is one of the causes of this disease.
Yunpeng XIE +6 more
doaj +1 more source
Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. [PDF]
, 2019 Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability.
Cannon, Stephen C +4 more
core +1 more source