Results 31 to 40 of about 32,023 (271)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase ...
Nader S. Abutaleb +8 more
doaj +1 more source
Respiratory challenge MRI: practical aspects [PDF]
, 2016 Respiratory challenge MRI is the modification of arterial oxygen (PaO2) and/or carbon dioxide (PaCO2) concentration to induce a change in cerebral function or metabolism which is then measured by MRI.
Dani, Krishna A. +4 more
core +2 more sources
FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour [PDF]
, 2008 Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Ferretti, P. +4 more
core +3 more sources
Efficacy of Acetazolamide in Refractory Epilepsy Management: A Quasi-Experimental Study
Pakistan Armed Forces Medical Journal, 2023 Objective: To assess the efficacy of Acetazolamide in refractory epilepsy management. Study Design: Quasi-experimental study. Place and Duration of Study: Outpatient Neurology Department, Allied Hospital, Faisalabad Pakistan, from Sep 2020 to Feb ...
Muhammad Ahmed Zamir +4 more
doaj +1 more source
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]
, 2019 A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A. +11 more
core +2 more sources
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies [PDF]
, 2018 Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating
Burbelo +14 more
core +1 more source
Evolution and diversity of alpha-carbonic anhydrases in the mantle of the Mediterranean mussel (Mytilus galloprovincialis) [PDF]
, 2019 The α-carbonic anhydrases (α-CAs) are a large and ancient group of metazoan-specific enzymes. They generate bicarbonate from metabolic carbon dioxide and through calcium carbonate crystal formation play a key role in the regulation of mineralized ...
Anjos, Liliana +6 more
core +1 more source
PulmonologyBackground The carbonic anhydrase inhibitor acetazolamide stimulates ventilation through metabolic acidosis mediated by renal bicarbonate excretion. In animal models, acetazolamide attenuates acute hypoxia-induced pulmonary hypertension (PH), but its ...
M. Lichtblau +11 more
doaj +1 more source
Effect of acetazolamide and subsequent ventriculo-peritoneal shunting on clinical signs and ventricular volumes in dogs with internal hydrocephalus [PDF]
, 2015 Background: Acetazolamide is recommended for the reduction of cerebrospinal fluid production in canine internal hydrocephalus. The efficacy of the drug in terms of alleviation of the clinical symptoms and the restoration of normal ventricular volume has ...
Kolecka, Malgorzata +4 more
core +2 more sources
Advanced Science, EarlyView.Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim +6 more
wiley +1 more source