Results 71 to 80 of about 29,225 (214)

Mechanism of Cd-Induced Inhibition of Na-Glucose Cotransporter in Rabbit Proximal Tubule Cells: Roles of Luminal pH and Membrane-Bound Carbonic Anhydrase [PDF]

open access: yes, 2008
Background/Aims: We have previously reported that a complex of cadmium-metallothionein (Cd-MT) directly affects the apical Na-glucose cotransporter on the luminal side in proximal tubules, suggesting that Cd-MT is more toxic than CdCl2 in causing ...
Fujimura Akio   +4 more
core   +1 more source

Imaging and physiology across the high–low cerebrospinal fluid pressure spectrum: Navigating diagnostic uncertainty in headache practice

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study was conducted to provide a clinically oriented, mechanism‐based framework for interpreting neuroimaging across disorders of cerebrospinal fluid (CSF) pressure, with particular emphasis on patients who fall between classic diagnostic categories of spontaneous intracranial hypotension (SIH) and idiopathic intracranial ...
Andrew L. Callen, Kyle Jenkins
wiley   +1 more source

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. [PDF]

open access: yes, 2006
MinK-related peptide 2 (MiRP2) and Kv3.4 subunits assemble in skeletal muscle to create subthreshold, voltage-gated potassium channels. MiRP2 acts on Kv3.4 to shift the voltage dependence of activation, speed recovery from inactivation, suppress ...
Abbott, Geoffrey W   +2 more
core   +1 more source

Treatment of acute cryptococcal meningitis in HIV infected adults, with an emphasis on resource-limited settings [PDF]

open access: yes, 2018
BACKGROUND: Despite the advent and increasingly wide availability of antiretroviral therapy, cryptococcal meningitis (CM) remains a significant cause of mortality and morbidity amongst individuals with HIV infection in resource-limited settings.
Dedicoat, Martin   +3 more
core   +1 more source

Huntington's Disease‐like Syndrome as a Rare Presentation of CACNA1A‐Related Disorder

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Petros Boumis   +14 more
wiley   +1 more source

Phenotypic characteristics of paroxysmal dyskinesia in 25 cats

open access: yesJournal of Small Animal Practice, EarlyView.
Objectives Paroxysmal dyskinesia has, to date, been reported only systematically in Sphynx cats. This study aims to describe paroxysmal dyskinesia in additional breeds. Materials and Methods The medical records of cats from multiple hospitals presenting with episodes consistent with paroxysmal dyskinesia between 2020 and 2025 were retrospectively ...
T. Liatis   +5 more
wiley   +1 more source

Patients' Perceptions and Treatment Effectiveness [PDF]

open access: yes
An extensive literature relating patients’ expectations to treatment outcomes has not addressed the determinants of these expectations. We argue that treatment history is part of a reference point that influences patients’ expectations of how effective ...
Dan Firesner   +3 more
core  

Andersen-Tawil Syndrome [PDF]

open access: yes, 2006
Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Smith, Andrew H   +2 more
core   +1 more source

Role of extracellular carbonic anhydrase in the polar diatom Fragilariopsis cylindrus

open access: yesNew Phytologist, EarlyView.
Summary Diatoms are major primary producers in productive polar oceans, where cold temperatures and high CO2 solubility raise questions as to whether they rely on the CO2‐concentrating mechanism (CCM) to saturate photosynthesis. Knowledge of CCM function will help better predict the sensitivity of diatom primary production to warming and acidifying ...
Meng Li, Jodi N. Young
wiley   +1 more source

Phenotype-dependent functional and pharmacological properties of BK channels in skeletal muscle: Effects of microgravity

open access: yesNeurobiology of Disease, 2005
We investigated the involvement of calcium-activated potassium channel (BK) in skeletal muscle phenotype determination and response to acetazolamide, a BK opener.
Domenico Tricarico   +2 more
doaj   +1 more source

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