Results 71 to 80 of about 1,276 (161)

Advancing Anticancer Drug Discovery: Leveraging Metabolomics and Machine Learning for Mode of Action Prediction by Pattern Recognition

Advanced Science, Volume 11, Issue 47, December 18, 2024.
This study explores the integration of metabolomics with machine learning to predict the mode of action (MoA) of anti‐proliferative drugs in cancer cells. Complex metabolite patterns of drug‐treated cells are trained by machine learning to classify the drug's MoA.
Mohamad Saoud, Jan Grau, Robert Rennert, Thomas Mueller, Mohammad Yousefi, Mehdi D. Davari, Bettina Hause, René Csuk, Luay Rashan, Ivo Grosse, Alain Tissier, Ludger A. Wessjohann, Gerd U. Balcke   +12 more
wiley   +1 more source

The immunosuppressive effect of boswellic acid in managing the inflammation and symptoms associated with psoriatic arthritis [PDF]

Psoriatic arthritis (PsA) is a long-term inflammatory autoimmune condition that affects the skin and joints. It is associated with psoriasis, a skin disorder that causes red, scaly patches.
Steffi Thomas, Pradeep Kumar Yadav, Shweta Kumari Saw, Guman, Upasana Sahu, Jayvant KumarSahu, Yunesh KumarMandavi,Hari Prasad Sonwani, Harsh Kumar Sao
core   +2 more sources

Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata [PDF]

, 2022
The study was designed to investigate the anti-inflammatory and analgesic effect of different fractions of Boswellia serrata. The effect of different fractions of Boswellia serrata were studied using carrageenan induced paw edema, acetic acid induced ...
A. G. Namdeo, A. Sharma, Ganesh N, K. R. Mahadik, M. D. Kharya, S. Bhatia, V. Gajbhiye   +6 more
core   +1 more source

Efficacy of Extracts of Oleogum Resin of Boswellia in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Phytotherapy Research, Volume 38, Issue 12, Page 5672-5689, December 2024.
ABSTRACT Knee osteoarthritis (OA) has recently been ranked as the 11th highest contributor to global disability. More than 40% of patients use complementary and alternative medicine including supplements containing phytoextracts with anti‐inflammatory properties as those from the Boswellia genus.
Thomas Dalmonte, Giulia Andreani, Cecilia Rudelli, Gloria Isani   +3 more
wiley   +1 more source

AN UPDATE ON PHARMACOLOGICAL PROFILE OF BOSWELLIA SERRATA [PDF]

, 2019
Boswellia serrata (Burseraceae) is the most ancient and respected herbs in Ayurveda. In Unani system of medicine, oleo-gum resin of Boswellia serrata named Kundur played a prime ingredient role in modern quality perfumes.
DHANESHWAR, SUNEELA, PILKHWAL, NAMEETA
core   +1 more source

Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G [PDF]

, 2018
Age-related diseases, such as osteoarthritis, Alzheimer’s disease, diabetes, and cardiovascular disease, are often associated with chronic unresolved inflammation. Neutrophils play central roles in this process by releasing tissue-degenerative proteases,
Fischer, Dagmar, Henkel, Arne, Jauch, Johann, Kather, Nicole, Koeberle, Andreas, König, Stefanie, Paul, Michael, Seitz, Stefanie, Tausch, Lars, Verhoff, Moritz, Werz, Oliver   +10 more
core   +1 more source

Endothelial Dysfunctions in Blood–Brain Barrier Breakdown in Alzheimer's Disease: From Mechanisms to Potential Therapies

CNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.
Blood–brain barrier (BBB) works as a crucial structure separating central nervous system (CNS) and circulating system. The highly organized endothelial junctions and transporters strictly restricts substance exchange across BBB to maintain the homeostasis of CNS.
Qian Yue, Xinyue Leng, Ningqing Xie, Zaijun Zhang, Deguang Yang, Maggie Pui Man Hoi   +5 more
wiley   +1 more source

Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study [PDF]

, 2017
Introduction: Acne is a multifactorial and common skin disease which can significantly affect the quality of life of sufferers. In this study, a topical herbal preparation traditionally used in Ayurvedic medicine was evaluated as a treatment for ...
Abdel Hay, Agnihotri, Ammon, Aruldass, Bae, Benjamin Lawley, Bhambri, Burke, Celia Bell, Chaitanya, Chaurasia, Chen, Cross, Cunha, Das, Dash, Dawson, Dessinioti, Dieu Thuan, Dumont-Wallon, Dutta, Francis, Ghosh, Gokhale, Gopalakrishnan, Hasson, Hassoun, Hong, Huw Jones, Karthy, Kaur, Kaushik, Kaushik, Khorasani, Khuda, Kimmatkar, Kubo, Kumar, Kurokawa, Leyden, Majdalawieh, McCarty, Milan Vu, Mukherjee, Nasri, Nishteswar, Oikawa, Parveen, Poma, Raja, Ramesh, Richter, Said, Sandhya, Sandra Appiah, Satyal, Saurat, Schofield, Shafiei, Shah, Sharma, Shinde, Soni, Su, Tara Shanbhag, Tewtrakul, Thiboutot, Tsai, Wani, Wanner, Watson, Wolf, Yadav, Zeng, Zu   +74 more
core   +1 more source

Novel formulations ameliorate osteoarthritis in rats by inhibiting inflammation and oxidative stress

Food Science &Nutrition, Volume 12, Issue 10, Page 7896-7912, October 2024.
Treatments F1 (curcuminoids + gingerols + AKBA) to F4 (curcuminoids + AKBA) improved joint diameter, stride length, and paw area in OA rats. They significantly reduced MDA levels and increased antioxidant enzyme activities by lowering inflammatory markers such as IL‐1β, IL‐6, MMP‐8, TNF‐α, CRP, COMP, and LOX‐5, while increase the anti‐inflammatory ...
Fusun Erten, Oguzhan Ozdemir, Muhammed Tokmak, Ali Said Durmus, Ibrahim Hanifi Ozercan, Abhijeet Morde, Muralidhara Padigaru, Kazim Sahin   +7 more
wiley   +1 more source

Spectroscopic method to estimate 3-Acetyl-11-keto-β-boswellic acid in complex lipid nanocarriers and skin matrices

Results in Chemistry
3-Acetyl-11-keto-β-boswellic acid (AKBA) is a phytoconstituent derived from Boswellia serrata extract. It shows anti-rheumatic activity by selectively and non-competitively inhibiting the 5-Lipoxygenase (5-LOX) enzyme.
Sakshi Priya, Vaibhavi Meghraj Desai, Gautam Singhvi   +2 more
doaj   +1 more source