Results 221 to 230 of about 38,176 (241)

Regulation of mammalian acetyl-CoA carboxylase

Biochemical Society Transactions, 2002
Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCα and ACCβ, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. They are regulated by similar short-term mechanisms of allosteric activation by citrate, and reversible ...
openaire   +2 more sources

Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase

Journal of Medicinal Chemistry, 2013
Acetyl-CoA carboxylase (ACC) is a target of interest for the treatment of metabolic syndrome. Starting from a biphenyloxadiazole screening hit, a series of piperazine oxadiazole ACC inhibitors was developed. Initial pharmacokinetic liabilities of the piperazine oxadiazoles were overcome by blocking predicted sites of metabolism, resulting in compounds ...
Matthew P, Bourbeau, Aaron, Siegmund, John G, Allen, Hong, Shu, Christopher, Fotsch, Michael D, Bartberger, Ki-Won, Kim, Renee, Komorowski, Melissa, Graham, James, Busby, Minghan, Wang, James, Meyer, Yang, Xu, Kevin, Salyers, Mark, Fielden, Murielle M, Véniant, Wei, Gu   +16 more
openaire   +2 more sources

Regulation of Spinach Chloroplast Acetyl-CoA Carboxylase

Archives of Biochemistry and Biophysics, 1998
We have investigated several factors which influence acetyl-CoA carboxylase (ACCase) activity in lysed spinach chloroplasts. (1) When assayed after rapid lysis of light-incubated chloroplasts, ACCase activity was 2-fold higher than activity from dark-incubated chloroplasts.
S C, Hunter, J B, Ohlrogge
openaire   +2 more sources

Soybean Chloroplast Acetyl-CoA Carboxylase

1997
Acetyl-CoA carboxylase (ACCase, EC 6.4.1.2) catalyzes an ATP-dependent conversion of acetyl-CoA to malonyl-CoA, which is a regulated step in de novo synthesis of fatty acids that takes place in chloroplasts. In soybean, the chloroplast ACCase is apparently a multiprotein, prokaryotic type of complex [1], that is thought to consist of 4 subunits: biotin
S. V. Reverdatto, V. Beilinson, N. C. Nielsen   +2 more
openaire   +1 more source

Acetyl‐CoA Carboxylase—a Graminicide Target Site

Pesticide Science, 1997
Acetyl-CoA carboxylase catalyses the first committed step in fatty acid (and acyl lipid) formation. The enzyme has been shown to exert a high degree of flux control for lipid biosynthesis in leaves and, therefore, it is not surprising that chemicals which can inhibit it effectively are successful herbicides.
Derek Herbert, Kevin A. Walker, Lindsey J. Price, David J. Cole, Kenneth E. Pallett, Stuart M. Ridley, John L. Harwood   +6 more
openaire   +1 more source

Acetyl-CoA Carboxylase Inhibitors

2002
Two important groups of herbicides, the cyclohexanediones (CHD) and aryloxyphenoxypropanoates (AOPP), inhibit the plastidic enzyme acetyl-CoA carboxylase (ACCase; E.C. 6.4.1.2). Representative compounds in these groups are shown in Fig. 1. A third class of inhibitor, based on a hybrid cyclic triketone structure, shows similar herbicidal activity ...
openaire   +1 more source

Plant acetyl-CoA carboxylase

Biochemical Society Transactions, 1986
A, Hellyer, H E, Bambridge, A R, Slabas
openaire   +2 more sources

Herbicides inhibiting acetyl-CoA carboxylase

Biochemical Society Transactions, 1994
openaire   +2 more sources

REGULATION OF ACETYL-CoA CARBOXYLASE

Nutrition Reviews, 2009
openaire   +2 more sources

[Acetyl-CoA carboxylase] kinase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source