Results 241 to 250 of about 56,101 (298)
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Regulation of acetyl-CoA carboxylase.
Biochemical Society Transactions, 2006Acetyl-CoA carboxylase (ACC) catalyses the formation of malonyl-CoA, an essential substrate for fatty acid synthesis in lipogenic tissues and a key regulatory molecule in muscle, brain and other tissues. ACC contributes importantly to the overall control
R. Brownsey +4 more
semanticscholar +4 more sources
Regulation of mammalian acetyl-CoA carboxylase.
Biochemical Society Transactions, 2002Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCalpha and ACCbeta, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively ...
M. Munday
semanticscholar +4 more sources
Structural basis for regulation of human acetyl-CoA carboxylase
Nature, 2018Moritz Hunkeler +2 more
exaly +2 more sources
Archives of Biochemistry and Biophysics, 1971
Abstract A biotin carboxyl carrier protein (BCCP) from Escherichia coli has been purified and crystallized. The purified protein was found to be homogeneous by polyacrylamide gel electrophoresis and sedimentation in a synthetic boundary cell. BCCP has a sedimentation coefficient of 1.04 S, a diffusion coefficient ( D 20,w ) of 10.4 × 10 −7 cm 2 ...
Alfred W. Alberts +2 more
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Abstract A biotin carboxyl carrier protein (BCCP) from Escherichia coli has been purified and crystallized. The purified protein was found to be homogeneous by polyacrylamide gel electrophoresis and sedimentation in a synthetic boundary cell. BCCP has a sedimentation coefficient of 1.04 S, a diffusion coefficient ( D 20,w ) of 10.4 × 10 −7 cm 2 ...
Alfred W. Alberts +2 more
openaire +2 more sources
Plant Molecular Biology, 1993
The acetyl-CoA carboxylase present in both wheat germ and total wheat leaf protein contains ca. 220 kDa subunits. It is the major biotin-dependent carboxylase present in wheat chloroplasts. Active acetyl-CoA carboxylase purified from wheat germ is a homodimer with an apparent molecular mass of ca. 500 kDa.
Robert Haselkorn, Piotr Gornicki
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The acetyl-CoA carboxylase present in both wheat germ and total wheat leaf protein contains ca. 220 kDa subunits. It is the major biotin-dependent carboxylase present in wheat chloroplasts. Active acetyl-CoA carboxylase purified from wheat germ is a homodimer with an apparent molecular mass of ca. 500 kDa.
Robert Haselkorn, Piotr Gornicki
openaire +3 more sources
Effect of insulin on association of acetyl CoA carboxylase phosphatase and acetyl CoA carboxylase
Biochemical and Biophysical Research Communications, 1985Insulin promotes an association between acetyl CoA carboxylase and acetyl CoA carboxylase phosphatase. The association between rat epididymal fat tissue carboxylase and the phosphatase occurs in both a tissue culture system and in vivo and is accompanied by an increase in acetyl CoA carboxylase activity.
Ki-Han Kim, Glenn R. Krakower
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Expert Opinion on Investigational Drugs, 2019
Introduction: Acetyl-CoA Carboxylase (ACC) is an essential rate-limiting enzyme in fatty acid metabolism. For many years, ACC inhibitors have gained great attention for developing therapeutics for various human diseases including microbial infections ...
Leyuan Chen +7 more
semanticscholar +1 more source
Introduction: Acetyl-CoA Carboxylase (ACC) is an essential rate-limiting enzyme in fatty acid metabolism. For many years, ACC inhibitors have gained great attention for developing therapeutics for various human diseases including microbial infections ...
Leyuan Chen +7 more
semanticscholar +1 more source
American Journal of Physiology, 1996
Malonyl-CoA, an inhibitor of fatty acid oxidation in skeletal muscle mitochondria, decreases in rat skeletal muscle during exercise or in response to electrical stimulation.
W. Winder, D. Hardie
semanticscholar +1 more source
Malonyl-CoA, an inhibitor of fatty acid oxidation in skeletal muscle mitochondria, decreases in rat skeletal muscle during exercise or in response to electrical stimulation.
W. Winder, D. Hardie
semanticscholar +1 more source
Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2
Science, 2001Malonyl–coenzyme A (malonyl-CoA), generated by acetyl-CoA carboxylases ACC1 and ACC2, is a key metabolite in the regulation of energy homeostasis. Here, we show thatAcc2 −/− mutant mice have a normal life span, a higher fatty acid oxidation rate, and ...
L. Abu-Elheiga +3 more
semanticscholar +1 more source