Results 121 to 130 of about 28,974 (220)

Targeting Fatty Acid Synthase With Berberine Promotes IL‐10 Production in Macrophages and Prevents Relapse in a Murine Colitis Model

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Berberine enhances IL‐10 production in macrophages via FASN‐dependent mechanisms, thereby promoting epithelial repair and preventing colitis relapse. Created with BioRender.com. ABSTRACT Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by alternating periods of remission and relapse.
Shusaku Hayashi, Yudai Ogawa, Nonoka Wakabayashi, Koga Tokuyama, Makito Oku, Takeshi Yamamoto, Shinichi Kato, Asma Nusrat, Makoto Kadowaki   +8 more
wiley   +1 more source

HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma

The Journal of Clinical Investigation
Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer driven by VHL loss and aberrant HIF-2α signaling. Identifying means to regulate HIF-2α thus has potential therapeutic benefit.
Zachary A. Bacigalupa, Emily N. Arner, Logan M. Vlach, Melissa M. Wolf, Whitney A. Brown, Evan S. Krystofiak, Xiang Ye, Rachel A. Hongo, Madelyn Landis, Edith K. Amason, Kathryn E. Beckermann, W. Kimryn Rathmell, Jeffrey C. Rathmell   +12 more
doaj   +1 more source

1.Purification and crystallization analysis of ArsA1-9N mutant in marine algae 2.Crystallization analysis of Acetyl-CoA synthetase in Vibro proteolyticus

, 2021
1. Purification and crystallization analysis of ArsA1-9N mutant in marine algae Tail-anchored membrane protein (TA protein) is a group of proteins that is different from most eukaryotic membrane proteins.
Li, Chia-Hsuan
core  

ACSS2 enables melanoma cell survival and tumor metastasis by negatively regulating the Hippo pathway

Frontiers in Molecular Biosciences
IntroductionAcetyl-CoA synthetase 2 (ACSS2), one of the enzymes that catalyze the conversion of acetate to acetyl-CoA, has been proved to be an oncogene in various cancers.
Baolu Zhang, Qing Zhu, Di Qu, Mao Zhao, Juan Du, Hengxiang Zhang, Hao Wang, Linhan Jiang, Xiuli Yi, Sen Guo, Huina Wang, Yuqi Yang, Weinan Guo   +12 more
doaj   +1 more source

Strukturelle Untersuchungen zur Funktion der Acetyl-CoA-Synthetase 1 aus Candidatus Korarchaeum cryptofilum und Charakterisierung der Struktur der Toll/Interleukin-1-Rezeptor-homologen Domäne aus Hydra magnipapillata TRR-2

, 2016
Nucleoside diphosphate-forming acetyl coenzyme A synthetases (ACDs) belong to the superfamily of nucleoside diphosphate-forming acyl-coenzym A synthetases and are significantly involved in the energy production during peptide and sugar fermentation in acetate-forming archaea.
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The effect of glucose on cardiac AMP-activated protein kinase

, 2009
AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core  

Examination of the brassica napus β-Keto-Acyl carrier protein reductase promoter for regulatory Cis-acting elements [PDF]

, 2002
Major interest has focused on the identification of regulatory factors involved in lipid biosynthesis. This study examined the B.napus β-Keto-ACP reductase 5' sequence for potential regulatory cis-acting elements.
Young, Clare Elisabeth
core  

Fatty acid biosynthesis. VIII. The fate of malonyl-CoA in fatty acid biosynthesis by purified enzymes from lactating-rabbit mammary gland

, 1971
- 1. We have investigated the formation and utilization of malonyl-CoA in fatty acid synthesis catalysed by preparations of partially purified acetyl-CoA carboxylase and purified fatty acid synthetase from lactating-rabbit mammary gland.
Hansen, Heinz Johs. Max, Dils, R., Carey, E.M.   +2 more
core   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source