Translational Oncology, 2022 Acetyl-CoA synthetases ACSS1 and ACSS2 promote conversion of acetate to acetyl-CoA for use in lipid synthesis, protein acetylation, and energy production.
Sarah Calhoun, Lei Duan, Carl G Maki
exaly +3 more sources
ACSS2 governs milk fat synthesis in buffalo via a reciprocal positive feedback loop with SREBP1 and PPARG [PDF]
Animal BioscienceObjective Acetyl-CoA synthetase 2 (ACSS2) converts rumen-derived acetate into acetyl-CoA in ruminants. Whether it actively regulates lactation-associated transcriptional networks beyond its catalytic role remains unclear. This study aimed to characterize
Lige Huang +5 more
doaj +2 more sources
Acetyl-coenzyme A synthetase 2-mediated acetyl-coenzyme A accumulation promotes mitophagy and tumor growth via increased H3K27ac in hepatitis B virus-related hepatocellular carcinoma [PDF]
Clinical and Molecular HepatologyBackground/Aims Acetyl coenzyme A (acetyl-CoA) is one of the most essential metabolites in cell metabolism but its function and concentration in hepatocellular carcinoma (HCC) remain elusive and controversial.
Shan Li +12 more
doaj +2 more sources
Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development
Discover Oncology, 2022 Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA).
Xiang Tang, Deyu Chen, Chen Gong
exaly +2 more sources
ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease [PDF]
Cell RegenerationBackground Inflammatory bowel disease (IBD) remains a significant clinical challenge with limited curative options. Adipose-derived mesenchymal stem cells (ADSCs) hold therapeutic promise, but their anti-inflammatory efficacy is often compromised by ...
Ming Yuan +10 more
doaj +2 more sources
ACSS2 promotes proliferation and invasiveness of SKOV-3 and PA-1 ovarian cancer cell lines under hypoxia [PDF]
Journal of Ovarian ResearchObjective Ovarian cancer is the eighth most common malignancy among women worldwide. Despite advances in treatment, chemoresistance and associated morbidity remain significant challenges.
Ola Mroweh +7 more
doaj +2 more sources
ACSS2-TFEB axis acts as a critical regulator of the autophagic machinery in head and neck squamous cell carcinoma [PDF]
Cell Death and DiseaseHead and neck squamous cell carcinoma (HNSCC) has a high rate of metastasis and recurrence, and poses a considerable threat to patient survival. Autophagy, an intracellular degradation pathway, plays a crucial role in tumor progression; however, the ...
Danhui Yin +6 more
doaj +2 more sources
ACSS2 enables melanoma cell survival and tumor metastasis by negatively regulating the Hippo pathway
Frontiers in Molecular BiosciencesIntroductionAcetyl-CoA synthetase 2 (ACSS2), one of the enzymes that catalyze the conversion of acetate to acetyl-CoA, has been proved to be an oncogene in various cancers.
Hengxiang Zhang, Sen Guo, Yuqi Yang
exaly +3 more sources
Trifluoperazine upregulates ACSS2-related autophagy and promotes cerebral cognitive function in rats after sleep deprivation [PDF]
iScienceSummary: Cognitive function impairment following sleep deprivation (SD) can induce significant aftereffects. Elevated calmodulin (CaM) expression following stroke causes calcium overload—a key contributor to cognitive function impairment. Trifluoperazine
Caijun He +5 more
doaj +2 more sources
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression [PDF]
Nature CommunicationsAcetate is the end product of alcohol metabolism. Acyl-CoA synthetase short-chain family member 2 (ACSS2) converts acetate to acetyl-CoA, involving metabolic pathways and epigenetic regulation.
Mengyao Wang +17 more
doaj +2 more sources