Results 21 to 30 of about 2,979 (146)

ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells

Scientific Reports, 2023
Alkaliptosis is a recently discovered type of pH-dependent cell death used for tumor therapy. However, its underlying molecular mechanisms and regulatory networks are largely unknown.
Dongwen Que, Feimei Kuang, Rui Kang, Daolin Tang, Jiao Liu   +4 more
doaj   +3 more sources

An Oncolytic Vaccinia Virus Expressing Aphrocallistes Vastus Lectin Modulates Hepatocellular Carcinoma Metabolism via ACSS2/TFEB-Mediated Autophagy and Lipid Accumulation [PDF]

Marine Drugs
Hepatocellular carcinoma (HCC) remains a therapeutic challenge due to metabolic plasticity and drug resistance. Oncolytic viruses (OVs), such as thymidine kinase-deleted vaccinia virus (oncoVV), selectively lyse tumors while stimulating antitumor ...
Qiang Wang, Simeng Zhou, Yin Wang, Yajun Gao, Yanrong Zhou, Ting Ye, Gongchu Li, Kan Chen   +7 more
doaj   +2 more sources

High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

Cell Reports
Summary: MYCN amplification, a characteristic of aggressive neuroblastoma, presents therapeutic challenges. This study uncovered the potential effects of a fructose metabolite, acetate, on the transcriptional regulation of MYCN expression, which is still
Wenquan Hu, Qing Robert Miao
exaly   +3 more sources

Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells.

PLoS ONE, 2017
Survival of cancer cells in the harsh tumor microenvironment, characterized by oxygen and glucose deprivation, requires rapid initiation of cytoprotective measures.
Rui Chen, Min Xu, Jason Nagati, Joseph A Garcia   +3 more
doaj   +4 more sources

ACSS2 and the metabolic‐epigenetic axis in Alzheimer’s disease [PDF]

Alzheimer's & Dementia, 2020
AbstractBackgroundWe examine the contribution of the metabolic‐epigenetic regulatory axis1to protective histone acetylation in the brain, which is impaired in Alzheimer’s disease (AD). ACSS2 (acetyl‐CoA synthetase 2) is a key metabolic enzyme that is chromatin‐bound in neurons2.
Gabor Egervari, Shelley L. Berger
openaire   +1 more source

ACSS2 mediates prenatal alcohol exposure-related morphological and behavioral phenotypes. [PDF]

Neurobiol Dis
ABSTRACT The metabolic enzyme Acetyl-CoA Synthetase 2 (ACSS2) recently emerged as an unexpected regulator of molecular and behavioral changes associated with alcohol use. Its role during prenatal exposure, however, remains unknown. Here, we use a combination of proteomic, genomic and behavioral approaches to establish ACSS2 as a key ...
Dodson KM, Periandri EM, Yadav A, Lopes M, Barfield AJ, Ola A, de Luna Vitorino FN, Cearlock C, Garcia BA, Hill CA, Maloney SE, Egervari G.   +11 more
europepmc   +3 more sources

D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription

Pharmacological Research
CREB-regulated transcription coactivator 1 (CRTC1), a pivotal synaptonuclear messenger, regulates synaptic plasticity and transmission to prevent depression.
Yaxin Guo, Nuo Chen, Ming Zhao, Baihui Cao, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Yan Li, Lining Zhang   +9 more
doaj   +3 more sources

HIV latency is reversed by ACSS2-driven histone crotonylation [PDF]

Journal of Clinical Investigation, 2018
Eradication of HIV-1 (HIV) is hindered by stable viral reservoirs. Viral latency is epigenetically regulated. While the effects of histone acetylation and methylation at the HIV long-terminal repeat (LTR) have been described, our knowledge of the proviral epigenetic landscape is incomplete.
Guochun Jiang, Don Nguyen, Nancie M. Archin, Steven A. Yukl, Gema Méndez-Lagares, Yuyang Tang, Maher M. Elsheikh, George R. Thompson, Dennis J. Hartigan-O’Connor, David M. Margolis, Joseph K. Wong, Satya Dandekar   +11 more
openaire   +4 more sources

Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy

JCI Insight, 2023
Albuminuria and podocyte injury are the key cellular events in the progression of diabetic nephropathy (DN). Acetyl-CoA synthetase 2 (ACSS2) is a nucleocytosolic enzyme responsible for the regulation of metabolic homeostasis in mammalian cells.
Jian Lu, Xue Qi Li, Pei Pei Chen, Jia Xiu Zhang, Liang Liu, Gui Hua Wang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Zhong Ruan, Kun Ling Ma   +11 more
doaj   +1 more source

ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis. [PDF]

Cancer Res
Abstract Brain metastasis in breast cancer patients represents a terminal disease stage, with median survival typically measured in months. Tumors that colonize the brain must adapt to its unique microenvironment, such as high acetate levels. Primary brain tumor cells enhance acetate conversion to acetyl-CoA through phosphorylation of
Young RG, Esquea EM, Ciraku L, Merzy J, Ahmed NN, Talarico AN, Karuppiah M, Medori SM, Warade RP, Gocal W, Dick A, Simone NL, Reginato MJ.   +12 more
europepmc   +2 more sources