Results 11 to 20 of about 2,979 (146)

KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

Cell Reports
Summary: Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and linked to poor prognosis and therapeutic resistance. Emerging evidence suggests that specific KRAS mutations differentially influence treatment responses.
Jonathan Chernoff
exaly   +5 more sources

SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress [PDF]

eLife
De novo lipogenesis is associated with the development of human diseases such as cancer, diabetes, and obesity. At the core of lipogenesis lies acetyl coenzyme A (CoA), a metabolite that plays a crucial role in fatty acid synthesis.
Rezwana Karim, Wendi Teng, Cameron D Behram, Hening Lin   +3 more
doaj   +4 more sources

Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis

PLoS ONE, 2023
The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators including acetate-dependent acetyl CoA synthetase 2 (Acss2), Creb binding protein (Cbp), Sirtuin 1 ...
Joseph A. Garcia, Rui Chen, Min Xu, Sarah A. Comerford, Robert E. Hammer, Shelby D. Melton, Linda A. Feagins   +6 more
doaj   +4 more sources

Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

Molecular Metabolism
Quiescence is a reversible cell cycle exit traditionally thought to be associated with a metabolically inactive state. Recent work in muscle cells indicates that metabolic reprogramming is associated with quiescence.
Allison C. Sharrow, Emily Megill, Amanda J. Chen, Afifa Farooqi, Naveen Kumar Tangudu, Apoorva Uboveja, Stacy McGonigal, Nadine Hempel, Nathaniel W. Snyder, Ronald J. Buckanovich, Katherine M. Aird   +10 more
exaly   +5 more sources

Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells

Frontiers in Pharmacology
Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rely on the conversion of acetate to acetyl-CoA by the enzyme acetyl-CoA synthetase 2 (ACSS2), a key
Lorela Ciraku, Emily M Esquea, Adel A Rashad   +2 more
exaly   +5 more sources

ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Molecular Neurodegeneration, 2023
Background Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer’s disease (AD).
Yingbin Lin, Anlan Lin, Lili Cai, Weibin Huang, Shanzhi Yan, Yuanxiang Wei, Xinglin Ruan, Wenting Fang, Xiaoman Dai, Jinbo Cheng, Jie Zhang, Wanjin Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang   +14 more
doaj   +3 more sources

ACSS2-related autophagy has a dual impact on memory [PDF]

Chinese Neurosurgical Journal, 2019
Autophagy is an intracellular degenerative pathway which is responsible for neuronal survival. Under the condition of nutrient deprivation, autophagy can lead to dysfunction in memory consolidation.
Hao Zhang, Zujian Xiong, Qin He, Fan Fan
doaj   +3 more sources

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7 [PDF]

Advanced Science
Histone lysine crotonylation (Kcr), a highly conserved posttranslational modification, plays critical roles in various biological processes. Nevertheless, the dynamic alterations and functions of histone Kcr in inflammatory bowel disease (IBD) remain ...
Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu   +14 more
doaj   +2 more sources

ACSS2 and metabolic diseases: from lipid metabolism to therapeutic target

Lipids in Health and Disease
Elevated incidence of metabolic disorders has been reported worldwide in the recent decade, highlighting the need for developing efficient therapies. These diseases result from a complex interplay of various factors that contribute to disease progression,
Alaa El-Kurjieh, Reem Al-Arab, Qamar Abou Hachem, José-Noel Ibrahim, Philippe Hussein Kobeissy   +4 more
doaj   +3 more sources

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors [PDF]

Advanced Science
Besides the traditional carbon sources, Acetyl coenzyme A has recently been shown to be generated from acetate in various cancers, which subsequently promotes tumor growth and immune escape.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
doaj   +2 more sources