Results 31 to 40 of about 2,979 (146)

Regulated Acyl-CoA Synthetase Short-Chain Family Member 2 Accumulation During Spermatogenesis [PDF]

Cell Journal, 2019
Objective Acyl-CoA synthetase short-chain family member 2 (ACSS2) activity provides a major source of acetyl-CoA to drive histone acetylation. This study aimed to unravel the ACSS2 expression during mouse spermatogenesis, where a dynamic and stage ...
Afsaneh Goudarzi, Amir Amiri-Yekta
doaj   +1 more source

Prognostic Impact of Metabolism Reprogramming Markers Acetyl-CoA Synthetase 2 Phosphorylation and Ketohexokinase-A Expression in Non-Small-Cell Lung Carcinoma

Frontiers in Oncology, 2019
Background: The identification of prognostic markers for non-small-cell lung carcinoma (NSCLC) is needed for clinical practice. The metabolism-reprogramming marker ketohexokinase (KHK)-A and acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659 (ACSS2 ...
Xueying Yang, Fei Shao, Fei Shao, Fei Shao, Susheng Shi, Xiaoli Feng, Wei Wang, Yalong Wang, Wei Guo, Juhong Wang, Shugeng Gao, Yibo Gao, Zhimin Lu, Jie He   +13 more
doaj   +1 more source

Fatty acid metabolism-an emerging regulatory node in T-cell immunometabolism. [PDF]

Clin Transl Immunology
Abstract While the roles of glucose metabolism and tricarboxylic acid (TCA) cycle intermediates in immune regulation are well established, the contribution of fatty acid metabolism remains less well defined. In this review, we examine current knowledge on the immunomodulatory functions of fatty acid metabolism, with a particular focus on T‐cell biology.
Arenberg BC, Sack MN, Wu J.
europepmc   +2 more sources

ACSS2 coupled with KAT7 regulates histone β-hydroxybutyrylation to enhance transcription. [PDF]

Sci Adv
Histone lysine β-hydroxybutyrylation (Kbhb) is an epigenetic mark linking ketone metabolism to transcription. However, the molecular mechanism by which β-hydroxybutyrate is converted to β-hydroxybutyryl–coenzyme A (BHB-CoA), the cofactor for Kbhb, remains unknown.
Wang S, Niu Z, Zhang Y, Liu R, Zhu R, Sun Y, Han Y, Wang A, Zhang J, Zhang H, Zang Y, Zhao Y, Zhai G, Zhang K.   +13 more
europepmc   +3 more sources

Role and mechanism of ACSS2-mediated epithelial-mesenchymal transition in ethanol-promoted migration of colorectal cancer

陆军军医大学学报, 2023
Objective To explore the role and underlying mechanisms of Acyl-CoA synthetase short chain family member 2 (ACSS2) in ethanol-promoted migration of colorectal cancer (CRC) cells.
SUN Yan, SUN Yan, WANG Lingqiao, ZHANG Guowei   +3 more
doaj   +1 more source

Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Reprogramming energy metabolism is an emerging hallmark of many cancers, and this alteration is especially evident in renal cell carcinomas (RCCs). However, few studies have been conducted on lipid metabolism. This study investigated the
Lv Yao, Xiaoqiang Guo, Yaoting Gui
doaj   +1 more source

Rapamycin antagonizes cadmium-induced breast cancer cell proliferation and metastasis through directly modulating ACSS2

Ecotoxicology and Environmental Safety, 2021
Cadmium (Cd) is a carcinogen that stimulates breast cancer (BC) progression. Rapamycin is a macrolide antibiotic produced by Streptomyces hygroscopicus that possesses a wide array of pharmacological activities, including anti-BC activity.
Yidan Liang, Lai Yi, Ping Deng, Liting Wang, Yang Yue, Hui Wang, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Zhengping Yu, Huifeng Pi, Zhou Zhou   +12 more
doaj   +1 more source

ACSS2 involved in acetyl-CoA synthesis regulates skeletal muscle function. [PDF]

FEBS Lett
Acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, regulating cholesterol metabolism. Given the discovery of a muscular dystrophy associated with 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), a key enzyme in ...
Gunasekaran M, Campos G, Wells NM, Lambuu K, Draper I, Pacak CA, Kang PB.   +6 more
europepmc   +4 more sources

Commentary: Possible involvement of ACSS2 gene in alcoholism [PDF]

Integrative Neuroscience Research, 2018
Alcoholism is a psychiatric disorder of multifactorial etiology, wherein interaction between genetic and environmental factors results in heightened alcohol seeking behavior. However, there is still much to be explored and understood about how imbalances between the biological-psychological-social axes can influence the quality an individual's mental ...
openaire   +1 more source

D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels

Translational Psychiatry, 2023
The potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (BDNF) and tryptophan hydroxylase 2 (TPH2) is well characterized to facilitate rapid and long-lasting antidepressant actions.
Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhang   +11 more
doaj   +1 more source