Results 151 to 160 of about 28,974 (220)

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase

, 1994
5 pages, 2 figures.Yeast (Saccharomyces cerevisiae) acetyl coenzyme A (CoA) synthetase (EC 6.2.1.1) catalyzes the synthesis of adenosine 5'-tetraphosphate (P4A) and adenosine 5'-pentaphosphate (p5A) from ATP and tri- or tetrapolyphosphate (P3 or P4 ...
Günther Sillero, María A., Guranowski, Andrzej, Sillero, Antonio   +2 more
core  

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

The FEBS Journal, Volume 293, Issue 12, Page 3528-3544, June 2026.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek, Miroslava Vosahlikova, Zsofia Kutil, Zora Novakova, Julia Kudlacova, Ruzena Tuckova, Marat Meleshin, Barbora Havlinova, Pavlina Jaklova, Jana Ptackova, Cordelia Schiene‐Fischer, Mike Schutkowski, Cyril Barinka   +12 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, Volume 293, Issue 12, Page 3565-3587, June 2026.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Energy Stress‐Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Energy stress via glucose deprivation activates AMPK and protects dopaminergic neurons from ferroptosis by limiting lipid peroxidation. In contrast, glucose availability supports ferroptosis through oxidizable lipid pools. ABSTRACT Ferroptosis, an iron‐dependent form of regulated necrosis, is implicated in the pathogenesis of Parkinson's disease (PD ...
Aurélie Jonneaux, William Laine, Patrice Maboudou, Jérôme Kluza, Marie‐Amandine Bonte, Flore Gouel, David Devos, Philippe Marchetti, Jean‐Christophe Devedjian   +8 more
wiley   +1 more source

The Elusive Fraction of Marine Plankton Diversity: Size, Abundance and Taxonomic Composition of 0.2 μm‐Filterable Prokaryotes Across Three Contrasting Coastal Environments

Molecular Ecology, Volume 35, Issue 12, June 2026.
ABSTRACT The existence of prokaryotes escaping filtration through 0.2‐μm filters has been known for decades. Such ‘filterable’ prokaryotes (hereafter ‘FP’) might include true ultra‐small groups (i.e., ultramicrobacteria), but also cells that miniaturize temporally as a physiological strategy to persist under unfavourable conditions, representing a ...
Clara Ruiz‐González, Cristina Andres‐Barrao, Anders Lanzén, Laura Alonso‐Sáez, Hugh Ducklow, Josep M. Gasol, Xosé Anxelu G. Morán   +6 more
wiley   +1 more source

Cytokinin downregulates Photosystem II photochemistry during prolonged darkness in a phytochrome B‐dependent manner

New Phytologist, Volume 250, Issue 6, Page 3846-3866, June 2026.
Cytokinin–phyB signaling modulates PSII photochemistry during prolonged darkness. Summary Cytokinins (CKs) delay dark‐induced senescence, but how they tune photosynthetic function in darkness remains unclear. We investigated the effects of classical aromatic CK benzylaminopurine and CK‐derived compound 1‐(2‐methoxyethyl)‐3‐(1,2,3‐thiadiazol‐5‐yl)urea ...
Veronika Kábrtová, Zuzana Kučerová, Ivo Chamrád, René Lenobel, Pavel Roudnický, Jan Skalák, Martin Hudeček, Filip Zavadil Kokáš, Marek Rác, Tereza Vánská, Jaroslav Nisler, Jan Hejátko, Miroslav Strnad, Martina Špundová, Ondřej Plíhal   +14 more
wiley   +1 more source

The Cryptosporidium "mouse" genotype is conserved across geographic areas.

, 1999
A 298-bp region of the Cryptosporidium parvum 18S rRNA gene and a 390-bp region of the acetyl coenzyme A synthetase gene were sequenced for a range of Cryptosporidium isolates from wild house mice (Mus domesticus), a bat (Myotus adversus), and cattle ...
Hamilton, S.G., Sturdee, A.P., Thompson, R.C.A., Torres, J., Morgan, U.M., Gracenea, M., Singleton, G., Gomez, M.S., Woodside, D.P.   +8 more
core  

Crystal structure of 3-hydroxypropionyl-CoA synthetase (ADP-forming) from <i>Nitrosopumilus maritimus</i>. [PDF]

Curr Res Struct Biol
Johnson J, Tosun B, Yilmaz M, Tolar BB, Yoshikuni Y, Francis CA, Doukov T, Yokoi S, Wakatsuki S, DeMirci H.   +9 more
europepmc   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source