Results 201 to 210 of about 25,053 (234)

Acetyl-L-Carnitine Hydrochloride

Drugs of the Future, 1995
The title compound, 2-acetoxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride, C 9 H 18 NO 4 + .Cl - , represents a source of activated acetyl groups which are efficiently used for biosynthetic purposes. The crystal structure reported here confirms the extended conformation of the compound predicted from solid-state NMR studies and differs from ...
H. P. Weber, R. C. Anderson, M. Shapiro, E. B. Villhauer, T. Gullion   +4 more
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Acetyl-L-Carnitine in Neuropathic Pain

CNS Drugs, 2007
Acetyl-L-carnitine (ALC) has gained clinical interest for its analgesic effect in different forms of neuropathies associated with chronic pain, such as diabetic and HIV-related peripheral neuropathies. The antinociceptive effect of ALC has been confirmed in several experimental models of neuropathic pain, including streptozotocin- and chemotherapy ...
CHIECHIO, SANTINA, COPANI, Agata Graziella, GEREAU RW TH, NICOLETTI F.   +3 more
openaire   +5 more sources

Acetyl‐L‐Carnitine in dementia

International Journal of Geriatric Psychiatry, 1991
AbstractThis study was designed to test the benefit of acetyl‐l‐carnitine in patients with dementia. Seventy‐one patients of 65 years and over, living in their own homes or in residential care, took part in a 24‐week randomized, double‐blind, placebo‐controlled, parallel‐group clinical trial.
G. A. Livingston, K. B. Sax, Z. McClenahan, E. Blumenthal, K. Foley, J. Willison, A. H. Mann, I. M. James   +7 more
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Acetyl-l-Carnitine Treatment in Minimal Hepatic Encephalopathy

Digestive Diseases and Sciences, 2008
Minimal hepatic encephalopathy (MHE) is characterized by disturbance of mental state and neuromuscular function. To assess the clinical efficacy of acetyl-L: -carnitine (ALC) in the treatment of MHE, we performed a randomized, double-blind, placebo-controlled study administering ALC in cirrhotic patients with this disease and evaluating their cognitive
MALAGUARNERA, Mariano, GARGANTE MP, CRISTALDI E, VACANTE M, RISINO C, CAMMALLERI L, PENNISI, Giovanni, RAMPELLO, Liborio   +7 more
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Uptake of acetyl-l-carnitine in the brain

Neurochemical Research, 1989
Analysis in mouse brain slices of the uptake of acetyl-L-[N-methyl-14C]carnitine with time showed it to be concentrative, and kinetic analysis gave a Km of 1.92 mM and a Vmax of 1.96 mumol/min per ml, indicating the presence of a low-affinity carrier system.
A P, Burlina, H, Sershen, E A, Debler, A, Lajtha   +3 more
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Acetyl-l-carnitine: Behavioral, electrophysiological, and neurochemical effects

Neurobiology of Aging, 1993
Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were tested: young controls (4 mo-con),
S, Davis, A L, Markowska, G L, Wenk, C A, Barnes   +3 more
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Entry of acetyl-l-carnitine into biosynthetic pathways

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
[1-14C]Acetyl-L-carnitine was injected into fed and fasted mice and the time-course of distribution of 14C in various tissues and tissue components was determined. The major product was 14CO2. However, considerable quantities of radioactivity were localized in liver with much smaller quantities in heart, brain, skeletal muscle and kidney.
S, Farrell, J, Vogel, L L, Bieber
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Acetyl-l-carnitine as a precursor of acetylcholine

Neurochemical Research, 1990
Synthesis of [3H]acetylcholine from [3H]acetyl-L-carnitine was demonstrated in vitro by coupling the enzyme systems choline acetyltransferase and carnitine acetyltransferase. Likewise, both [3H] and [14C] labeled acetylcholine were produced when [3H]acetyl-L-carnitine and D-[U-14C] glucose were incubated with synaptosomal membrane preparations from rat
H L, White, P W, Scates
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Acetyl-l-carnitine reduces impulsive behaviour in adolescent rats

Psychopharmacology, 2004
The attention deficit/hyperactivity disorder (ADHD) can affect human infants and adolescents. One important feature of this disorder is behavioural impulsivity. This study assessed the ability of chronic acetyl-L-carnitine (ALC, saline or 100 mg/kg SC, plus 50 mg/kg orally) to reduce impulsivity in a validated animal model for ADHD.
Walter Adriani, REA, MONICA, Baviera, William Invernizzi, Mirjana Carli, Orlando Ghirardi, Antonio Caprioli, Giovanni Laviola   +7 more
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Acetyl-L-carnitine in hepatic encephalopathy

Metabolic Brain Disease, 2013
Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, and increased reaction time, sensory ...
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