Potential 14‐3‐3 binding sites in sirtuins reveal extended phosphosite‐recognition modes
Acta Crystallographica Section F, Volume 82, Issue 1, Page 32-40, January 2026.Identification, binding measurements and structure determination of human sirtuin phosphopeptides in complex with human adapter protein 14‐3‐3σ reveal variations among tight binders and suggest extended binding modes.The adapter proteins of the 14‐3‐3 family modulate the activity and/or localization of their binding partners, which they capture if a ...
Michael Weyand +2 more
wiley +1 more source
Integrative Adipogenic Engineering of Cultured Fat for Cell Based Meat
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 1, January 2026.ABSTRACT Adipose tissue is a key determinant of the sensory, nutritional, and functional qualities of meat, yet its faithful replication in vitro remains one of the central challenges for cultured meat production. This review first examines the roles of fat in conventional meat, encompassing its contributions to flavor, texture, and nutritional value ...
Young‐Seung Lee +2 more
wiley +1 more source
Staphylococcus aureus modulates the activity of acetyl-Coenzyme A synthetase (Acs) by sirtuin-dependent reversible lysine acetylation. [PDF]
Mol Microbiol, 2019 Burckhardt RM +2 more
europepmc +1 more source
Both Acetate Kinase and Acetyl Coenzyme A Synthetase Are Involved in Acetate-Stimulated Change in the Direction of Flagellar Rotation in Escherichia coli [PDF]
, 1998 Rina Barak +2 more
openalex +1 more source
Age‐Dependent Metabolomic Signatures of Dietary Restriction in Mice
Aging Cell, Volume 25, Issue 1, January 2026.Elevated hepatic glutathione (GSH) and 3‐hydroxybutyrate (3‐HB) levels in all ages of mice demonstrate an enhanced protection against oxidative stress and improvement in energy metabolism during chronic dietary restriction (DR). However, high protein or muscle degradation in liver of young mice, and large accumulation of hepatic glycogen and excessive ...
Ji‐sue Lee +4 more
wiley +1 more source
Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models. [PDF]
Emerg Microbes Infect, 2019 Jiménez de Oya N +15 more
europepmc +1 more source
Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction
Aging Cell, Volume 25, Issue 1, January 2026.In this study, we demonstrated that metabolic responses to a daily‐fed caloric restriction (CR) protocol remain robust in mice that cannot engage in canonical ketogenesis. This surprising finding is due to mice physiologically adapting to the daily bouts of fasting during CR by downregulating ketone production. ABSTRACT Caloric restriction (CR) extends
Chung‐Yang Yeh +13 more
wiley +1 more source
N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines. [PDF]
J Oncol, 2019 Stepp MW +4 more
europepmc +1 more source