Results 191 to 200 of about 204,757 (287)

Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies. [PDF]

Cell Commun Signal
Ding J, Wang H, Yang Z, Wang X, Cao Z.
europepmc   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Exploring the Impact of Nanotherapeutics on Histone H3 and H4 Acetylation Enrichment in Cancer Epigenome: A Systematic Scoping Synthesis. [PDF]

Epigenomes
Shirvaliloo M, Khoee S, Khoei S, Sheervalilou R, Mohammad Hosseini P, Afzalipour R, Shirvalilou S.   +6 more
europepmc   +1 more source

Histone Acetylation in Central and Peripheral Nervous System Injuries and Regeneration: Epigenetic Dynamics and Therapeutic Perspectives [PDF]

Georgina Palomés‐Borrajo, Xavier Navarro, Clara Penas   +2 more
openalex   +1 more source

Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification

, 2020
Duk‐Hwa Kwon, Juhee Ryu, Young‐Kook Kim, Hyun Kook   +3 more
openalex   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Regulation of Histone Acetylation During Inflammation Resolution. [PDF]

Immunotargets Ther
Gong L, Lei J, Zhou Y, Zhang J, Wu L, Chen Y, Liu X, Li Y.   +7 more
europepmc   +1 more source

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

Advanced Science, EarlyView.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang, Ruiying Qiang, Yuan Zhang, Jinxian Wan, Chen Tao, Ying Dong, Xujun Tang, Li Xu, Hairong Xiao, Yanqin Lin, Wei Tong, Ying Ma, Yongming Wang, Peng Li, Renjie Chai   +14 more
wiley   +1 more source

Reciprocal control of metabolic and chromatin regulators improves rice tolerance to heat. [PDF]

Nat Commun
Yue Y, Liu B, Xu Q, Chen Z, Wang J, Zhao Y, Zhou DX.   +6 more
europepmc   +1 more source

A salmonella toxin induces persister formation via acetylation of tRNA

, 2016
Angie Cheverton
openalex   +1 more source