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THE ACETYLATION OF PROTHROMBIN
Canadian Journal of Biochemistry and Physiology, 1960Purified bovine prothrombin was acetylated to a range of 27 to 30% of its amino groups. Except for just significant amounts it lost its power to generate thrombin-C. Upon activation the yield of thrombin-E was 100% on the basis of the thrombin-C yield that was obtained on an aliquot sample of the prothrombin before acetylation.
R H, LANDABURU, W H, SEEGERS
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Nonenzymic acetylation of histones with acetyl phosphate and acetyl adenylate
Biochemistry, 1975Nonenzymatic acetylation of calf-thymus lysine- and arginine-rich histones was demonstrated to occur when these proteins were incubated with [14C]acetyl phosphate and [14C]acetyl adenylate. The levels of acetylation depend on both pH and on reagent concentration.
RAMPONI, GIAMPIETRO +2 more
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Acetyl-CoA, protein acetylation, and liver cancer
Molecular Cell, 2022Using multi-omics approaches, Park et al. show that reduced cellular acetyl-CoA and protein hypoacetylation promote liver cancer growth and dedifferentiation.
Zhengming, Wu, Kun-Liang, Guan
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Clonazepam acetylation in fast and slow acetylators
Clinical Pharmacology and Therapeutics, 1981Six slow acetylators (SAs) and six rapid acetylators (RAs), as determined by sulfamethazine (SMZ) phenotyping, were each given a 2-mg oral dose of clonazepam. Ninety-six-hour urine collections from these subjects were analyzed for clonazepam, 7-amino clonazepam (7-AM, clonazepam nitroreduced metabolite), and 7-acetamido clonazepam (7-ACT, N-acetylated ...
Miller, Marvin E. +5 more
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